Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0598934 (
tumor growth
)
58,965
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Loss of
ABI gene family member 3-binding protein
(
ABI3BP
) expression may be functionally involved in the pathogenesis of cancer. Previous reports have indicated a loss of expression in lung cancer and a presumed role in inducing cellular senescence. We show here that
ABI3BP
expression is significantly decreased in most malignant thyroid tumors of all types. To better understand
ABI3BP
's role, we created a model by re-expressing
ABI3BP
in two thyroid cancer cell lines. Re-expression of
ABI3BP
in thyroid cells resulted in a decrease in transforming activity, cell growth, cell viability, migration, invasion, and
tumor growth
in nude mice.
ABI3BP
re-expression appears to trigger cellular senescence through the p21 pathway. Additionally,
ABI3BP
induced formation of heterochromatin 1-binding protein gamma-positive senescence-associated (SA) heterochromatin foci and accumulation of SA beta-galactosidase. The combination of a decrease in cell growth, invasion, and other effects upon
ABI3BP
re-expression in vitro helps to explain the large reduction in
tumor growth
that we observed in nude mice. Together, our data provide evidence that the loss of
ABI3BP
expression could play a functional role in thyroid tumorigenesis. Activation of
ABI3BP
or its pathway may represent a possible basis for targeted therapy of certain cancers.
...
PMID:Re-expression of ABI3-binding protein suppresses thyroid tumor growth by promoting senescence and inhibiting invasion. 1855 58
