Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0598934 (tumor growth)
 58,965 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to know whether laryngeal cancer draining lymph node lymphocytes (INL) have antitumor effects in vivo, we transfered IL-2 activated LNL to nude mice with human laryngeal squamous cell carcinoma line PHC3 xenografts, and observed a suppressive effect on tumor growth. It was also found in the epitype changes of LNL by indirect immunofluorencence method the major composition of freshly isolated LNL was CD3+ T cells in which there were more Th/i cells than Ts/c cells, CD4+/CD8+ ratio was 3.30 +/- 0.653. No evidence of lymphocytes multiplication or CD3+, CD4+, CD8+ epitype changes was found after short term IL-2 culture, but we found more HLA-DR+, CD25+ cells which means there was an increase in activated lymphocytes after culture. The experiment suggests that laryngeal cancer draining lymph node lymphocytes have antitumor effects in vivo after IL-2 short term culture, and can be used in clinical immunotherapy.
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PMID:[The experimental treatment of laryngeal cancer using local draining lymph node lymphocytes]. 927 99