Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0598934 (tumor growth)
 58,965 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The antitumor effect of dicyclohexylammonium sulfate (DCHA), a potent inhibitor of spermidine synthase, was tested on BDF1 mice inoculated i.p. with P388 leukemia (1 X 10(6) cells/mouse). DCHA prolonged the survival time of mice bearing P388 leukemia at the doses of 10-100 mg/kg administered daily for 6 days. The spleen weight increased by 30% at 7 days after tumor inoculation. DCHA treatment had no effect on the tumor-induced increase in splenic weight. The spermidine concentration of the ascites tumor cells and spleens of mice bearing the tumor was lowered by the treatment, while spermine concentration hardly changed. The depletion of spermidine in the ascites tumor cells and spleens might be a cause of the suppression of tumor growth.
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PMID:Antitumor effect of dicyclohexylammonium sulfate, a potent inhibitor of spermidine synthase against P388 leukemia. 711 28

The antitumor effect of dicyclohexylammonium sulfate (DCHA), a potent inhibitor of spermidine synthase, was tested on mice inoculated with Ehrlich ascites carcinoma, Ehrlich solid carcinoma and solid sarcoma-180. DCHA prolonged the survival time of mice bearing Ehrlich ascites carcinoma at doses of 50 approximately 100 mg/kg/day X 5. For Ehrlich solid carcinoma and solid sarcoma-180 the tumor growth was suppressed significantly at doses of 2 approximately 50 mg/kg/day X 10. The spermidine concentration of the tumor cells was lowered, while the spermine concentration hardly changed. The depletion of spermidine in the tumor cells might be a cause of the suppression of tumor growth.
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PMID:Antitumor effect of dicyclohexylammonium sulfate, a potent inhibitor of spermidine, synthase. 733 14