Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0598934 (
tumor growth
)
58,965
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
DDX46
, a member of the DEAD-box (DDX) helicase family, is involved in the development of several tumors. However, the exact role of
DDX46
in osteosarcoma and the underlying mechanisms in tumorigenesis remain poorly understood. Thus, in the present study, we explored the role of
DDX46
in osteosarcoma and the underlying mechanisms. Our results demonstrated that the expression levels of
DDX46
in both mRNA and protein were greatly elevated in human osteosarcoma tissues and cell lines. Knockdown of
DDX46
obviously inhibited osteosarcoma cell proliferation and
tumor growth
in vivo. In addition, knockdown of
DDX46
also significantly suppressed migration and invasion in osteosarcoma cells. Furthermore, knockdown of
DDX46
substantially downregulated the phosphorylation levels of PI3K and Akt in SaOS2 cells. In summary, the present results have revealed that
DDX46
plays an important role in osteosarcoma growth and metastasis. Knockdown of
DDX46
inhibited osteosarcoma cell proliferation, migration, and invasion in vitro and
tumor growth
in vivo. Therefore,
DDX46
may be a potential therapeutic target for the treatment of osteosarcoma.
...
PMID:Knockdown of DDX46 Inhibits the Invasion and Tumorigenesis in Osteosarcoma Cells. 2769 93
