Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
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Query: UMLS:C0598934 (
tumor growth
)
58,965
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Hemangiopericytoma
(
HPC
) is a highly vascularized mesenchymal tumor. Local recurrence and distant metastasis are common features of
HPC
. Considering the remarkable hyper-vasculature phenotype of
HPC
, we assumed that dysregulated angiogenic signaling pathways were involved in
HPC
. The key components of angiogenic signaling pathways including VEGF-VEGF-R2, EphrinB2-EphB4 and DLL4-Notch were examined by real-time RT-PCR, Western blotting and immunostaining in 17 surgical specimens of
HPC
patients and in 6 controls. A significant upregulation of VEGF and VEGF-R2 associated with elevated levels of p-Akt and proliferating cell nuclear antigen (PCNA) was detected in
HPC
. Moreover, a dramatic increase in the mRNA and protein expression of EphB4 and its downstream factor p-Erk1/2 was found in
HPC
. A massive activation of core-components of DLL4-Notch signaling was detected in
HPC
. Double-immunofluorescent staining confirmed the expression of these upregulated key factors in the endothelial cells of tumor vessels. The present study identified the activation of multiple and crucial angiogenic signaling pathways, which could function individually and/or synergistically to stimulate angiogenesis in
HPC
and eventually contribute to
tumor growth
and progression. Our findings emphasize the importance to target multiple angiogenic signaling pathways when an anti-angiogenic therapy is considered for this highly vascularized tumor.
...
PMID:Activation of multiple angiogenic signaling pathways in hemangiopericytoma. 2695 Dec 38
