Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0598934 (
tumor growth
)
58,965
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Myopodin was previously reported as a gene that was frequently deleted in prostate cancer. This gene shares significant homology with a cell shape-regulating gene, synaptopodin. Myopodin was shown to bind actin and to induce actin bundling when cells were stimulated. To clarify the functional role of
myopodin
in prostate cancer, several assays were performed to evaluate the tumor suppression activity of
myopodin
. Our results indicate that
myopodin
inhibits
tumor growth
and invasion both in vitro and in vivo. The activity of tumor suppression of
myopodin
is located at the C-terminus region. To further evaluate the role of
myopodin
in suppressing the invasiveness of prostate cancer, an expression analysis of
myopodin
protein was performed in prostate tissues. The results indicate that down-regulation of
myopodin
expression occurs mostly in invasive stages of prostate cancer, implying a potential invasion suppression role for
myopodin
in prostate cancer. In addition, hemizygous deletion and down-regulation of
myopodin
expression occur in three aggressive prostate cancer cell lines. All these results support the hypothesis that
myopodin
functions as a tumor suppressor gene to limit the growth and to inhibit the metastasis of cancer cells.
...
PMID:Expression of myopodin induces suppression of tumor growth and metastasis. 1511 26
Myopodin was identified as a tumor suppressor gene that is frequently deleted in aggressive prostate cancer. Expression of
myopodin
protein suppresses both
tumor growth
and metastasis in vitro and in vivo. In the present study employing a yeast two-hybrid system, we found that zyxin, a molecule known to regulate cell motility and migration, binds with
myopodin
with high affinity. The binding between zyxin and
myopodin
seems to be direct. Screening of a series of
myopodin
deletion mutants and peptide competition analyses revealed that
myopodin
is bound by zyxin at a site located within the sequence of the 19 amino acids at the
myopodin
COOH terminus. Importantly, this is the same region where the tumor suppressor activity of
myopodin
is located. The motility and invasion suppression activity of
myopodin
were significantly weakened in
myopodin
mutants lacking this sequence. Thus, our studies suggest that zyxin may be a critical functional regulator of
myopodin
.
...
PMID:Myopodin-mediated suppression of prostate cancer cell migration involves interaction with zyxin. 1688 36
