Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0598934 (tumor growth)
 58,965 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To evaluate the usefulness of alpha-1-antitrypsin as a tumor marker for pancreatic islet cell tumors, serum levels were measured in 16 patients including 4 with gastrinomas, 4 with glucagonomas, 1 with a malignant somatostatinoma 1 with a malignant insulinoma, and 6 with "nonfunctioning" islet cell carcinoma and in 10 controls. Serum alpha-1-antitrypsin ranged from 190-420 mg/dl in controls (normal serum values with this method range between 200-450 mg/dl). Serum levels of alpha-1-antitrypsin ranged from 150-900 mg/dl in the 16 patients with islet cell tumors. Only 3 of the 16 patients had elevated levels of alpha-1-antitrypsin. In this group of patients with advanced disease, serum alpha-1-antitrypsin was not a sensitive marker, and it is not likely to be useful for diagnostic screening or for monitoring tumor growth in patients with pancreatic islet cell tumors.
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PMID:Serum levels of alpha-1-antitrypsin in pancreatic islet cell tumors. 609 24