Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0598934 (tumor growth)
 58,965 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Lymphocytic infiltration of parenchyma and stroma of transitional cell tumors of human urinary bladder was assessed separately by quantitative morphometric procedures. The study established an increased level of lymphocytic infiltration of urothelium in areas adjacent to tumor matched by a relevant decrease in simple papillomas. Infiltration level remained unchanged in proliferating papillomas and papillomas with multiple carcinomas in situ. This parameter was raised in papillomas with local cell atypia, local invasion and single carcinomas in situ as well as in transitional cell cancers. These data are in collision with the hypothesis of progressive failure of cell-mediated immunity in tumorigenesis. The results suggest tumor growth stimulation by lymphocytes.
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PMID:[Degree of lymphocytic infiltration of the epithelium in bladder tumors]. 688 Jan 36

Xenografts of nude mice bearing human ovarian carcinoma cell line SKOV3 were transplanted using subrenal capsule assay (SRCA) in immunocompetent C57BL/6 mice. Multiple locations were chosen on both sides of the kidneys obtaining a total of 129 tumors. The volumes of the tumors were measured and histopathological examinations were conducted on the 4th, 6th, 8th, 10th, 12th and 14th days after transplantation surgery. The growth rates were noticed to be high on the 6-8th days. Lymphocytic infiltration reached a peak on the 8-12th day. On the 14th days the leukocytic infiltration and fibrosis almost surrounded the tumors. Tumor cells that could be found amounted to about 77.25%, 65.38%, and 52.17% respectively on the 4th, 6th and 8th days, but significantly decreased on 12-14th days. The above results suggested: (1) multiple SRCA on both sides proved to be practical and economical; (2) the xenografts of nude mice bearing hman ovarian carcinoma could be transplanted viably by SRCA for 8-10 days; (3) microscopic measurements of the transplanted tumor volume did not represent the real status of the tumor growth, and microscopic evaluation was necessary.
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PMID:[The analysis of tumor growth rate and histopathology of xenografts of nude mice bearing human ovarian carcinoma in immunocompetent mice]. 779 49