Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0598934 (tumor growth)
 58,965 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Primary extranodal lymphoma manifestation in the narrow sense is the term used to define the primary organ manifestation of a malignant lymphoma, excluding the thymus, spleen, Waldeyer's tonsillar ring, the appendix and Peyer's patches. However, in the clinical routine the term is also used for the secondary organ manifestation of underlying lymphoproliferative disease. Primary extranodal lymphomas are mainly non-Hodgkin lymphomas; there is primary extranodal manifestation of Hodgkin's disease in only about 1% of the cases. Among the extranodal NHL, the highly malignant forms predominate. A major exception is MALT lymphomas, which mainly show low slow growth. In the past, they were considered to be pseudolymphomas because of their slow and localized tumor growth. They were included as an entity of their own for the first time in the Revised European American Lymphoma (REAL) classification of 1994. The incidence data vary between < 10% and 25% for primary extranodal manifestation. The major reason for this is the difference in extranodal regions because of classification. Secondary organ involvement of an NHL occurs in up to 40% of the cases in the long-term course of the disease in primary nodal lymphomas. Secondary organ involvement is frequently diagnosed in AIDS patients who develop an AIDS-related lymphoma (85% of cases). The following contribution reports on the radiological imaging of extranodal lymphoma manifestation in the thoracoabdominal region.
 ...
PMID:[Radiologic diagnosis of primary extranodal lymphoma manifestations]. 915 74

Primary mediastinal (thymic) large B-cell lymphoma is a discrete clinicopathologic subtype of diffuse large cell lymphoma recognized in the revised European-American lymphoma classification. It is an uncommon but not rare tumor with worldwide distribution. For the clinician, the occurrence of this aggressive, invasive, yet localized neoplasm arising in an unusual site in a cohort of young adult patients (frequently women) in whom large cell lymphoma is infrequent is noteworthy. The pathologist is impressed both by the characteristic sclerosis and the unusual surface immunoglobulin (SIg)-negative B-cell phenotype of a tumor arising in a T-cell organ (thymus). The phenotype is that of a B-cell subset resident in the thymic medulla. The pattern of spread resembling that of extranodal lymphoma and the excellent response to appropriate combination chemotherapy and irradiation further support the discrete character of mediastinal large cell lymphoma, and provide a practical reason for recognizing the entity. Poorly chosen or executed primary therapy can lead to rapid tumor growth or regrowth with treatment failure and death, but a reassuringly high cure rate follows appropriate management.
 ...
PMID:Primary large cell lymphoma of the mediastinum. 1037 82

Intravascular lymphoma or intravascular lymphomatosis (IVL) is an uncommon extranodal lymphoma, which gives rise to exclusively intravascular tumor growth. In 1/3 of the reported cases the disease debuts with involvement of the nervous system, which is particularly susceptible. Over the clinical course of the disease, 2/3 of the patients will present neurological symptoms. Owing to its characteristic growth pattern, IVL can give rise to very different central or peripheral nervous system neurological syndromes. Not infrequently a single patient will present more than one neurological syndrome. Moreover, the specificity of the neurological tests is low. All these factors explain the difficulties involved in diagnosing this entity and the fact that in most cases the diagnosis is established on autopsy study. This article presents the clinical, biological, radiological and post-mortem neuropathological findings in an immunocompetent patient with IVL. The onset was a cauda equina syndrome and showed multiple and varied neurological manifestations during the course of the disease, which progressed in the months before death. Spinal cord biopsy performed in life did not provide diagnostic findings because the vessels showed no neoplastic involvement. Immunohistochemical findings demonstrated large B-cell lymphoma. A review of the neurological features described in previously published cases of IVL is provided.
 ...
PMID:Intravascular large B-cell lymphoma presenting with neurological syndromes: clinicopathologic study. 1770