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Query: UMLS:C0598934 (tumor growth)
 58,965 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An analysis is given of 50 observations of lung cancer associated with cancer of other organs. Lung cancer was preceded by cancer of another organ in 33 patients (66%), cancer of another organ developed after lung cancer had been cured--in 6 (12%), and synchronous involvement was noted in II (22%). An average interval between radical surgery for lung cancer and subsequent tumor growth in another organ was 6.2 years. Among patients with synchronous carcinomas the association with laryngeal cancer (4) and cancer of the stomach (4) was most frequently noted. The principles of treatment in patients with synchronous carcinomas are described.
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PMID:[Combination of primary lung cancer with extrapulmonary carcinomas]. 63 83

Biopsy specimens were taken from 130 laryngeal cancer patients and investigated before treatment. Autoradiography with 3H-thymidine was used to determine the labeling index (LI) of parenchymal cells and tumor stroma. Squamous cell carcinoma was diagnosed in all the cases. Altogether 41 patients were irradiated at a total focal dose of 32-40 Gy and underwent surgery. A full course of radiotherapy at a total dose of 52-60 Gy was given to 89 patients, however recurrences were detected in 38. Comparison of the therapeutic results and indices of proliferative activity of tumor cells has shown: 1. interrelationship of Ll of parenchymal cells and LlI of tumor stromal cells; 2. a tendency to correlation was revealed between indices of LI of parenchymal and stromal cells and a stage of disease; 3. correlation between a degree of a decrease in LI of parenchymal cells and completeness of tumor regression in the course of therapy was shown; 4. LI of stromal cells in the patients' tumors with resumption of tumor growth was lower (0.8) than in patients without resumed growth.
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PMID:[The labeling index of parenchymal and stromal tumor cells--an index of radiosensitivity and prognosis of laryngeal cancer]. 188 Dec 81

We report the growth characteristics of seven human laryngeal carcinomas transplanted into athymic mice. Six of the tumors were harvested from surgical pathology specimens and one was from a laryngeal carcinoma cell line. Tumor tissue measuring 2-3 cubic millimeters was implanted subcutaneously into the flank of the mice. Time intervals between implantation and active growth were recorded and tumor volume was calculated weekly. Mice were sacrificed at various time intervals. For three tumors, second and third passages of the tumor were performed. Successful tumor growth was achieved in 6/7 (85.7%) tumors. Primary implantation of tumor was performed in a total of 26 mice, 17 of which grew successfully. The average time interval between tumor implantation and measurable tumor growth for the five zenografts derived directly from patients was 36 days (range 25-40 days). The mean doubling time was 16 days (range 7-30 days). The overall take rate per animal for serial passage of tumor was 36 out of 43 (83.7%). The lag phase and the mean tumor doubling time decreased with each successive passage. At autopsy most tumors were confined to the subcutaneous structures by a well-formed capsule. Lymph node metastases and disseminated metastases were not seen. We conclude that the athymic mouse model is suitable to establish primary tumor growth of human laryngeal cancer.
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PMID:Growth characteristics of human laryngeal carcinoma in athymic mice. 204 Oct 60

This paper presents the results of fibroendoscopic examinations of 74 patients with laryngeal cancer of II-IV degree. Tumor dissemination was T2NO in 25 patients, T3NO in 36 patients, and T4NO in 13 patients. All the patients underwent modified resection patterns: 53 patients--horizontal resection (4 modifications) and 21 patients--frontolateral resection in the lower modification. Altogether 170 fibroendoscopic examinations were performed. Fibrolaryngoscopy helps to examine all laryngeal structures, evaluate and differentiate changes after various modifications of organ-preserving operations in the case of laryngeal cancer, and to detect at an early postoperative stage further tumor growth. Correct assessment of postoperative changes in the larynx prior to fibrolaryngoscopy can be carried out on the basis of reliable information about the operation, amount of tissue removed, and organ reconstruction.
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PMID:[Clinical and endoscopic aspects of surgically treated laryngeal cancer]. 238 28

As a result of a marked effect of the 1st stage of radiation therapy of 44 patients with stage III (T3N0M0) laryngeal cancer it was followed by therapy after a radical program up to a summary focal dose of 65-70 Gy. Continued tumor growth and recurrences were diagnosed in 19 patients, of them radical operation was performed on 12, 25 patients (57%) have been followed-up for 3 years, without signs of either recurrence or metastases with the preserved larynx. The above results suggest the effectiveness of radiation therapy in locally advanced laryngeal cancer.
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PMID:[Radiation therapy of stage III laryngeal cancer]. 260 91

The authors present the results of repeated radiotherapy of 86 patients with laryngeal cancer; of them 64 (74.4%) had local recurrences, 13 (15.2%) extended tumor growth and 9 (10.4%) metastases to the neck lymph nodes. Immediate cure was achieved in 36 (42%) patients, the volume of involvement not exceeding 1 cm3 irrespective of the site of a recurrence in the larynx. Long-term results were followed up in 74 patients after repeated irradiation. Thirty-seven patients have been alive from 1 to 13 years, disease extension was noted in 13, 19 patients were operated upon, and 5 died of laryngeal cancer. Late radiation complications were revealed in 13 (17.5%) patients. Basing on the previous results (V. V. Kholin, 1979, 1981) one can conclude that in order to avoid radiation complications the summary focal dose in repeated irradiation should not exceed in an equivalent value the optimum single therapeutic dose of 24 Gy with reference to 1 cm3 of the involvement volume.
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PMID:[Effectiveness of repeated radiotherapy in patients with laryngeal cancer]. 674 83

It is considered that malignant tumors appear more often when cellular immunity is deficient. Skin DNCB tests were positive in 40% of the cases with early laryngeal cancer, as compared with the 85--90% of positive responses obtained in healthy persons. T-lymphocytes and their products (lymphokines and transfer factors) play an important role. Although B-lymphocytes and their humoral antibodies are the main factors contributing to faster tumor growth, an interaction can occur between T and B lymphocytes, leading sometimes to synergism. The patient's immunologic status during the course of disease and the local reaction of lymphocytes in the tumor area are two important elements in the prognosis and therapeutic approach.
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PMID:Recent theoretical and practical problems in the cell mediated immunological reactions in cases of laryngeal cancer. 699 28

In order to know whether laryngeal cancer draining lymph node lymphocytes (INL) have antitumor effects in vivo, we transfered IL-2 activated LNL to nude mice with human laryngeal squamous cell carcinoma line PHC3 xenografts, and observed a suppressive effect on tumor growth. It was also found in the epitype changes of LNL by indirect immunofluorencence method the major composition of freshly isolated LNL was CD3+ T cells in which there were more Th/i cells than Ts/c cells, CD4+/CD8+ ratio was 3.30 +/- 0.653. No evidence of lymphocytes multiplication or CD3+, CD4+, CD8+ epitype changes was found after short term IL-2 culture, but we found more HLA-DR+, CD25+ cells which means there was an increase in activated lymphocytes after culture. The experiment suggests that laryngeal cancer draining lymph node lymphocytes have antitumor effects in vivo after IL-2 short term culture, and can be used in clinical immunotherapy.
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PMID:[The experimental treatment of laryngeal cancer using local draining lymph node lymphocytes]. 927 99

Laryngeal carcinoma-associated antigens in tissue and serum of patients with laryngeal carcinoma and normal adults were detected by using ABC and ELISA methods. The results showed that the positive rate rised from 80-86.6% to 97.7% by applying mixed monoclonal antibodies compared with single monoclonal antibody against laryngeal cancer. It was also found that the level of laryngeal carcinoma-associated antigens was much higher in serum of laryngeal carcinoma group than that of control group. The statistic difference was very significant (P < 0.01). The level was different with clinical types, stages and increased in line with the tumor growth. So it was suggested that the mixed monoclonal antibodies were sensitive and specific, which was considered as a useful tumor marker for diagnosis, monitoring clinial course and judging prognosis of patient with laryngeal carcinoma.
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PMID:[The detection of laryngeal carcinoma-associated antigens in tissue and serum using three mixed monoclonal antibodies against laryngeal cancer]. 927 4

A patient with early laryngeal cancer who rejected both radiation therapy and surgery was treated with only chemotherapy of UFT combined with CBDCA. UFT (tegafur 300 mg/day) was administered orally and CBDCA was injected intravenously at a dose of 300 mg/body every 1-2 months, 11 times. For over 2 years the patient has demonstrated gradual tumor growth, but has not complained of dyspnea and has worked every day. The chemotherapy has improved his quality of life.
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PMID:[A case of laryngeal cancer treated for over 2 years with UFT and CBDCA alone]. 1006 3


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