Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0598934 (tumor growth)
 58,965 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two cases of esophageal primary melanoma in females aged 63 and 68 years with nodular and lentiginous forms of growth are reported. The diagnosis was made intraoperatively and at autopsy, respectively. Morphogenetically, there were primary multiple non-simultaneous zones of tumor growth with the apposition growth as a form of tumor progression. Early stages of morphogenesis were characterized by atypical borderline melanocytic activity, melanoma in situ with a starting invasive growth being basic criteria for diagnosis of primary esophageal melanoma in examination of endoscopic and surgical material.
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PMID:[Primary esophageal melanoma ]. 1176 14

Clinical guidelines suggest that suspicious pigmented lesions of the plantar or palmar area require biopsy for early detection of acral melanoma. We present here a case of acral lentiginous melanoma in which various melanocytic atypia was observed at each biopsy site, including focal melanocytic proliferation. We suggest that this atypical melanosis is part of a contiguous phase of invasive tumor growth, which is known as the very early stage of melanoma in situ. In addition, noninvasive dermoscopy has been effective for the early discovery of hidden lesions of acral melanoma.
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PMID:Acral Lentiginous Melanoma Developing during Long-standing Atypical Melanosis: Usefulness of Dermoscopy for Detection of Early Acral Melanoma. 2190 19