Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0598934 (tumor growth)
 58,965 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During the course of preoperative chemotherapy for treatment of malignant fibrous histiocytoma of the lower extremity, the mass in three patients was found to be enlarged at physical examination. Magnetic resonance (MR) imaging demonstrated, and subsequent pathologic examination of resected specimens proved, that the enlargement was caused by extensive hemorrhage within the masses, rather than by tumor growth. MR imaging can demonstrate this phenomenon well, particularly on T1-weighted images.
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PMID:Hemorrhage simulating tumor growth in malignant fibrous histiocytoma at MR imaging. 165 83

T lymphocytes from rats with malignant fibrous histiocytoma at different stages of tumor growth were investigated for sensitization to bovine myelin basic protein (MBP). The immunological reactivity was assessed by a leukocyte adherence inhibition assay as an in vitro correlate of cellular immunity. We found that only T lymphocytes obtained 4 and 6 days after tumor transplantation are reactive to MBP (1-2 micrograms/ml). Since the sequence of the antigenic determinants from MBP is known, our findings may make it possible to select synthetic epitopes for generating cytotoxic T lymphocytes to these tumor cells.
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PMID:Cellular immunity to bovine myelin basic protein in rats bearing malignant fibrous histiocytoma. 248 89

The study was concerned with development of parameters to be used in making prognosis of survival in squamous-cell cancer of the skin, fibrosarcoma, malignant fibrous histiocytoma of the bone, leiomyosarcoma, rhabdomyosarcoma, secondary chondrosarcoma, chondroma and osteochondroma. One of them--tumor growth rate--is a maximum tumor size/case history duration ratio (Formula: see text). Other coefficients represent ratios between some characteristics (maximum size or Tt.s) and parameters of a patient's status (height, weight/height ratio, body surface area). A correlation between the suggested coefficients and survival was established.
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PMID:[Clinico-morphological indices for the differential diagnosis and prognosis of the course of a series of malignant tumors]. 282 Jan 46

Forty-four cases of malignant fibrous histiocytoma were studied. A new index for patients' survival prognosis was developed and defined as a tumor growth rate. It is a ratio of maximal tumor size and duration of disease. Eight clinical x-ray and morphological factors of prognosis were identified: duration of disease, clinical manifestations, size and roentgenologic type of tumor, pattern of tumor contours, status of the cortical layer in bone lesions, tumor growth rate and morphologic grade of malignancy. A multifactorial analysis was carried out and data were presented in tables. Values of each parameter were calculated.
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PMID:[Prognostic significance of the clinical x-ray and morphological signs in malignant fibrous histiocytoma of bone]. 282 91

High-resolution P-31 MR spectra were obtained in four patients with bone tumors of their distal extremities. In one case the tumor, a Ewing sarcoma of the tibia, was investigated during clinical remission after radiation therapy and chemotherapy. The other three cases - one low-grade chondrosarcoma of the tibial head, one malignant fibrous histiocytoma of the tibia, and one chondroblastoma of the medial femoral condyle - showed clinically active tumor growth, with corresponding increased metabolism as demonstrated by bone scintigraphy. The spectra of the three active tumors indicated a comparably high adenosine triphosphate content, similar to previously published spectra from animal tumors or human tumors implanted into animals. There were also high resonances of inorganic phosphate and low resonances of phosphocreatine; there were definite peaks in the phosphodiester and phosphomonoester regions, indicating the existence of these metabolites in the tumors. Slight but definite changes in the metabolite content were observed in one tumor after chemotherapy. The spectra of the unaffected leg did not show any well-resolved P-31 signals, which is typical for healthy bone. These are the first P-31 MR spectra of human bone tumors measured in patients to our knowledge.
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PMID:Extremity bone tumors: evaluation by P-31 MR spectroscopy. 299 71

The significance of neovascularization for tumor growth and metastasis has recently been postulated for human cancers; increased microvessel density correlates with increased frequency of metastasis. In the present study, microvessel density was examined in 42 cases of malignant fibrous histiocytoma (MFH). Microvessels were defined as lumens surrounded by anti-factor-VIII-related antigen (FVIII-RA)-antibody-stained endothelium, and counted in a x 400 field. The number of microvessels varied from 4 to 79 (median 14.5). When cases were divided into groups with less than or greater than 20 microvessels, there were no prominent differences in age distribution, sex ratio, size of tumor, depth of tumor, and histologic subtypes between the two groups. The number of microvessels in 19 cases with and 22 cases without metastasis was 19.4 +/- 14.9 and 19.6 +/- 17.4, respectively. Angiogenesis is apparently not a key factor in the formation of metastasis by MFH.
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PMID:Angiogenesis in malignant fibrous histiocytoma. 752 71

Sixty-three patients with malignant and benign tumors of soft tissues were examined making use of magnetic resonance computer-aided tomography (MRT). This method was found effective in the diagnosis of soft tissue tumors, permitting the detection of tumor connection with the adjacent structures. In some cases MRT helped differentiate between malignant and benign soft tissue tumor growth, e.g. liposarcoma, malignant fibrous histiocytoma, lipoma, desmoid, hematoma. MRT may be effectively used in the diagnosis of soft tissue formations.
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PMID:[Magnetic resonance computerized tomography in the diagnosis of soft tissue neoplasms]. 780 81

Local recurrence of tumor is a common phenomenon in soft tissue sarcoma (STS) and may be accompanied by an increase in malignant potential. In the present study, an increase of proliferative activity in recurrent tumors compared to primary tumors was observed using a silver stain for nucleolar organizer regions (AgNOR), and its implication for predicting prognosis is assessed. 44 patients with STS showing local tumor recurrence were selected. Local recurrence was defined as new tumor growth more than 2 months after the initial surgery in the same region where the primary tumor occurred. All patients received surgery, followed in 11 patients by adjuvant radiotherapy and/or chemotherapy. The histologic subtype was malignant fibrous histiocytoma in 22 cases, synovial sarcoma in 5, leiomyosarcoma in 4, liposarcoma in 3, malignant schwannoma in 3, and others in 7. The interval between initial surgery and local recurrence ranged from 2 to 72 months. No patients changed from one histological subtype to another. Histological changes included an increase in mitosis, cellularity, and sclerosis in 43.2, 31.8, and 27.3%, respectively. The AgNOR count (mean +/- SD) in recurrent tumors (7.22 +/- 2.59) was significantly higher than that in primary tumors (5.58 +/- 2.28; p < 0.0057), clearly showing a tendency for an increase in proliferative activity during recurrence. The 5-year survival rate of patients with a marked increase (> 4) in AgNOR count (16.7%) was worse than with minor to moderate increases (60.0%; p < 0.02). Marked AgNOR increase was more frequently observed in the tumors located in the head and neck and retroperitoneum (40%) than in other sites (9%). Irrespective of the primary site of tumors, a marked AgNOR increase resulted in an unfavorable prognosis. Multivariate analysis of change in histologic factors including AgNOR, cellularity, mitotic counts, pleomorphism, myxoid change, necrosis, sclerosis, and tumor size showed that increase of AgNOR counts was significant (p < 0.05). The present findings suggest that AgNOR counts can be used as a prognostic factor in recurrent STS.
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PMID:Usefulness of argyrophilic nucleolar organizer staining for predicting prognosis of patients with recurrent soft tissue sarcoma. 819 7

To clarify the relationship between local recurrence of mesenchymal tumors and their malignant potentiality, we made an experimental recurrence model for malignant fibrous histiocytoma (MFH) induced by 4-hydroxyaminoquinoline 1-oxide in the rat by repeated excisional operations. By the repeated excision, the number of recurrent tumors increased, and the doubling time of tumor growth was shortened. The mean doubling time of primary tumors was 6.6 days, that of the first locally recurrent tumors was 4.3 days, and that of the second locally recurrent tumors was 3.3 days. However, mitotic count and 5-bromo-2-deoxyuridine (BrdU) labeling index did not change. This study proved experimentally that MFH shows more rapid growth through repeated local recurrences, and this experimental model may provide a better understanding of the local recurrence of MFH.
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PMID:An experimental recurrence model for malignant fibrous histiocytoma induced by 4-hydroxyaminoquinoline 1-oxide in the rat. 838 25

Our laboratory morphogenetic studies have shown that most esophageal and intestinal tumors arise de novo, i.e. they are not necessarily preceded by the so-called "precancerous lesions". This is particularly true in the case of soft-tissue sarcoma (malignant fibrous histiocytoma and malignant hemangioendothelioma) which never involve "presarcoma" development. However, those investigations provided morphological characteristics of such early preinvasive cancers as carcinoma in situ and superficial cancer. Histological studies showed malignant fibrous histiocytoma to be low-differentiated sarcoma of fibroblastic origin. Wide-range morphogenetic potentialities of derivatives of the neural crest (miogenic differentiation) and Muller's epithelium (manifestation of connective-tissue properties) during tumor growth were identified in the course of the histogenetic examination of Triton experimental tumor and electron microscopy investigation of endometrial and ovarian tumor cells cultured in soft agar.
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PMID:[Morphogenetic studies in oncology]. 913 92


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