Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0598934 (tumor growth)
 58,965 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cellular proliferation activity in a series of salivary gland malignant tumors was evaluated using the index of proliferation cellular nuclear antigen (PCNA) immunoreactivity. A streptavidin-biotin immunoperoxidase method (ABC) using a monoclonal antibody PC10 demonstrated nuclear staining with varying intensity and distribution in all tumor specimens. Acinic cell carcinoma (n = 5) and polymorphous low-grade adenocarcinoma (n = 1) showed relatively low proliferation fractions. In adenoid cystic carcinoma (n = 13), PCNA-positive nuclei were mainly distributed in neoplastic myoepithelial cells which were the predominant cells in tumor growth. No statistically significant difference was found between cribriformtubular and solid subtypes. In adenocarcinoma (n = 6), a well differentiated papillary-cystic pattern expressed a significantly higher PCNA index than poorly differentiated solid pattern, showing the loss of the relationship between PCNA expression and differentiation. Tumor cell differentiation appears to be more important than proliferation in determining biological behavior and prognosis.
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PMID:Proliferating patterns of salivary gland adenocarcinomas with the use of PCNA labeling. 891 72

Acinic cell carcinoma of the salivary glands is a rare cancer representing a low grade malignancy. The recurrence of a tumor is sometimes encountered, usually within 5 years of initial operation. We describe an unusual recurrence after a long interval following primary surgery. In 1987, a 60-year-old woman underwent excision of a mass in the superficial lobe of the right parotid gland under the preoperative diagnosis of a benign tumor. A histologic diagnosis of acinic cell carcinoma was made by examining sections from the resected mass. The patient noted several small nodules in the right parotid region in 1995, but she did not visit our clinic until 1998 when tenderness developed. A locally recurrent tumor and cervical lymph nodes containing metastases were resected and postoperative radiotherapy was given 11 years after the first operation. At least 10 years of follow-up may be necessary for patients with acinic cell carcinoma because of slow-tumor growth.
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PMID:Late recurrence of acinic cell carcinoma of the parotid gland. 1068 18