Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0598934 (tumor growth)
 58,965 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

59 pubescent rats in whom were determined proliferations and tumors in the spermatogenic epithelium were treated with large doses of estrogens, including sinestrol and diethylstilbestrol. 83 other animals were noted with proliferations and tumors in the testicular interstitial cells and were treated with large doses of androgens or progesterones. Treatment for both groups lasted 9-11 weeks, after which the morphological condition of the testes was examined and the content of luteinizing and follicle stimulating hormone was determined. Estrogens caused a depression of the follicle stimulating hormone and a simulataneous stimulation of luteinizing hormone which lead to the cessation of teratoma seminoma growth. The androgens and progesterones lead to a depression of luteinizing hormone which caused the cessation of tumor growth and to the resolution of proliferations in the interstitial cells.
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PMID:[Hormontal treatment of pre-tumorous diseases of the testis in rats]. 85 73

Just as concerns that vasectomy might predispose its acceptors to cardiovascular disease have been largely discounted, Cole et al. have obtained results suggesting that vasectomy accelerates the growth of testicular tumors. Out of a cohort of over 3000 vasectomized men in Scotland, 8 developed testicular cancer within 4 years of the procedure. The expected number of cases would be 1.9. Earlier, Thornhill et al reported 3 cases of a rare mixed seminoma and malignant teratoma 8 weeks after vasectomy. Numerous studies have found abnormalities in testicular biopsy specimens from vasectomized men. These changes include degeneration of seminiferous epithelium, loss of germ cells such as spermatids, dilatation of testicular tubules, thickening of tubular walls, and interstitial fibrosis. More research is needed on factors (i.e., a history of orchitis or family history of autoimmune disease) that may predispose men to different forms of testicular change as well as the association between the formation of sperm granulomas and testicular abnormalities. Most important, however, is further investigation of the proposed association of vasectomy and accelerated tumor growth.
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PMID:Vasectomy and the human testis. 222 12

We report a case of radiation-induced neurogenic fibrosarcoma that developed in a patient who received radiation therapy for seminoma. The sarcoma developed within the irradiated field after a latency period of nineteen years. Although the occurrence of a secondary neoplasm is unusual, this possibility should be included in the differential diagnosis of patients who present with tumor growth after a long interval following radiation therapy.
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PMID:Neurogenic fibrosarcoma following radiation therapy for seminoma. 277 68

Testicles of 15 subfertile men who underwent orchidectomy because of intratubular seminoma cells resp. carcinoma-in-situ (CSI) pattern in testicular biopsy were examined by semithin sections as well as by ultrathin sections. With one exception the volume of the testicles was reduced (means = 16 ml). 6 cases (= 40%) had exclusively intratubular seminoma cells, 4 cases (= 26.6%) intratubular and interstitial seminoma cells and 5 cases (= 33.3%) a solid seminoma near the rete testis. In all patients an interstitial inflammatory infiltration as well as tubular shadows of various degree could be observed. Some tubular shadows contained macrophages in the center heavily loaded with lipid droplets. Furthermore, in two cases many seminiferous tubules could be detected which contained activated macrophages in the lumen lysing tumor cells. One of the patients had only intratubular tumor cells, whereas the other patient had a solid seminoma near the rete testis. Our data suggest that activated macrophages killing intratubular tumor cells in patients with CIS pattern of the testis resp. with an early stage of a seminoma represent a physiological immunological reaction of the host in preventing further invasive tumor growth. Tubular shadows represent the final process of macrophage activity and may explain the reduced testicular volume in patients with CIS. However, the density of the inflammatory reaction and the extent of intratubular macrophages lysing tumor cells does not correlate with a low or high risk of tumor growth.
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PMID:Macrophages lysing seminoma cells in patients with carcinoma-in-situ (CIS) of the testis. 319 22

A case of bilateral seminoma of the testis is presented that occurred after a lag period of six years following right orchiectomy, even with correct cobalt therapy. The question of early detection of seminoma in the other testis is posed. A common consensus for repeat biopsies to detect new tumor growth should be determined.
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PMID:The search for a consensus for early detection of bilateral seminoma. 663

We report 2 cases of metastatic seminoma to emphasize the use of computed tomography in defining accurately the extent and volume of tumor before treatment. Computed tomography permits more direct visualization of the retroperitoneum, mesenteric and abdominal lymph nodes, and extra nodal extension of the tumor to other organ systems. Additionally, characteristic tissue densities are displayed (that is cyst and hemorrhage), which may serve as an index to the dynamics of tumor growth and change. Lymphography and venacavography are invasive studies and both share inherent limitations in imaging for seminoma. Cross-sectional imaging is more precise in describing treatment fields for radiation therapy. Results of treatment are monitored more confidently with computed tomography.
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PMID:Seminoma: improved imaging and tumor characterization with computed tomography. 735 21

Immunosuppressed transplant recipients are at significantly increased risk for developing neoplasms than are nonimmunosuppressed individuals. However, only six cases of pure testicular seminoma following renal transplantation have been reported in the English literature. This case report represents the first description of a seminoma arising in an undescended testis post-transplantation. We propose that it may be prudent to remove atrophic undescended testes when lifelong immunosuppressive therapy is anticipated, because accelerated tumor growth can occur.
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PMID:Testicular seminoma originating in an undescended testis in a renal allograft recipient. 869 40

Angiogenesis is essential for tumor growth and metastasis. A new human angiogenic mitogen, endocrine gland-derived vascular endothelial growth factor (EG-VEGF), has been recently identified; its expression pattern is restricted to endocrine glands, with the highest expression in testis. We used in situ hybridization and newly generated monoclonal antibodies to investigate the expression of EG-VEGF in normal human prenatal and adult testis and in 48 human testicular tumors of different subtypes. We found that EG-VEGF was expressed from 14 wk until birth in human fetal testis. In the adult testis, EG-VEGF was strongly expressed only in Leydig cells. In testicular tumors, EG-VEGF was expressed specifically in Leydig cell tumors, whereas germ cell-derived neoplasms, including carcinoma in situ, seminoma, and nonseminomatous germ cell tumors, were negative for this antigen. In contrast, VEGF, another powerful angiogenic factor, was expressed in seminoma, but very weakly in Leydig cell tumors. Interestingly, we found that Leydig cell tumors presented vessel surface density 3.2-fold higher than seminoma. These findings argue that human EG-VEGF may play a role in angiogenesis both during the early endocrine development of testis and in the adult testis as well as in Leydig cell tumor growth.
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PMID:Human endocrine gland-derived vascular endothelial growth factor: expression early in development and in Leydig cell tumors suggests roles in normal and pathological testis angiogenesis. 1529 51

There is an increased incidence of tumors of the genitourinary tract among kidney graft recipients. From 1979 to 2001, all patients who received kidney transplants had records of both their underlying diseases and their initial immunosuppression. Patients who developed a genitourinary tract malignancy were evaluated for tumor type, location, stage, tumor therapy and clinical course. During this period, 1804 patients underwent 2068 kidney transplantations. Thirty-four patients had 39 tumors of genitourinary origin. One patient was lost to follow-up. There were 15 patients with 18 renal cell carcinomas (one of them multifocal): six had seven transitional cell carcinomas; six, prostatic carcinoma; six, tumor of the female genital tract (one also had a renal cell carcinoma); and two, a seminoma. Most tumors were diagnosed in their early stages (< or = pT3, N0, M0; n = 31 tumors) and thus accessible to curative therapy, achieving good long-term results: 1- and 5-year survival rates of 100% and 91%, which were better than those obtained in advanced stages (N+, M+; n = 7 tumors), namely both 1- and 5-year survival rates of 38% (P < .05). Death was caused by tumor growth in nine patients (27%) and by other causes in three patients (9%). With appropriate treatment genitourinary tumors at early stage show a good prognosis. New immunosuppressants with supposed antiproliferative effects may help to decrease the incidence of malignancies. The most important factor is risk-adapted screening to identify malignancies early and to initiate appropriate therapy.
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PMID:Therapy and prognosis of tumors of the genitourinary tract after kidney transplantation. 1596 47

Insulin-like growth factors (IGF) have mitogenic and antiapoptotic functions, and may be involved in tumor growth. The purpose of the study was to investigate the role of IGF components in seminoma compared to normal testis. Normal testicular tissues from autopsy cases and seminoma from surgery cases were obtained for microarray and real-time reverse transcription polymerase chain reaction (RT-PCR) analysis of IGF-1, IGF-2, IGF receptor type 1 (IGF-R1), IGF-R2, insulin receptor isoforms A (IR-A) and B (IR-B), and IGF-binding proteins (IGFBP) 1-6. IGF-2 was localized by immunohistochemistry. IGFBP-5 protein expression was evaluated by Western blot analysis. mRNA expression in microarray and real-time RT-PCR showed similar tendencies: IGF-1, IGF-R1, IGF-R2, IR-A, and IGFBP-2 were not different in both groups. IGF-2, IR-B, IGFBP-1, IGFBP-4, and IGFBP-6 mRNA were downregulated in seminoma. IGFBP-3 tended to be upregulated in pT1 seminoma, but downregulated in pT2 stages. IGFBP-5 and IGF-2 protein expression correlated with mRNA expression. In conclusion, downregulation of mainly inhibiting IGFBPs may allow a stimulated tumor growth. The downregulated IGF-2 does not seem to be involved in the growth regulation of seminoma. Constantly expressed genes (e.g., IGF-1, IGF-R1, IR-A, and IGFBP-2) may reflect an involvement in spermatogenesis, but may also play a major role in tumor growth as their expression is not downregulated despite the lack of spermatogenesis in tumor tissue.
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PMID:Differential expression of IGF components and insulin receptor isoforms in human seminoma versus normal testicular tissue. 1596 97


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