Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0598934 (tumor growth)
 58,965 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Isozyme pattern of pyruvate kinase in the liver of nude mice bearing Ehrlich ascites tumor changed markedly during tumor growth. The change in isozyme pattern of pyruvate kinase was not due to infiltration or metastasis of tumor cells in the liver. Such a change in isozyme pattern of pyruvate kinase was also found in the liver of nude mice bearing canine gastric leiomyosarcoma induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), but not in the liver of nude mice bearing MNNG-induced canine gastric adenocarcinoma or human gastric adenocarcinoma.
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PMID:Deviation of isozyme pattern of pyruvate kinase in the liver of nude mice bearing allogeneic or xenogeneic tumor. 64 Mar 21

An 81/2-year-old female domestic short-haired cat was admitted with signs of chronic cystitis. Radiography revealed marked and irregular thickening of the bladder wall. Biopsy revealed the thickening to be a malignant tumor of muscle origin and treatment with proteolytic enzymes was instituted. After one month, the cat was euthanatized because of uremia associated with progressive tumor growth. At necropsy the bladder was grossly thickened. The histopathologic diagnosis was leiomyosarcoma.
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PMID:Leiomyosarcoma of the urinary bladder in a cat. 118 37

The leiomyosarcoma of vascular origin is a very rare tumor which is rarely recovered before the disease has reached an advanced stage because of non-specific and late symptoms. This is a report of 3 cases with leiomyosarcoma of the vena cava and a review of the literature. A high local recurrence rate and high frequency of distant metastases are responsible for the bad long-term prognosis. Early hematogenous tumor spread is favored by intraluminal tumor growth. Only complete surgical resection--if necessary with vascular reconstruction--can improve the bad long-term prognosis.
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PMID:[Leiomyosarcoma of the vena cava. Case report and review of the literature]. 187 Mar 67

A role for insulin-like growth factors (IGF) in autocrine or paracrine growth stimulation of tumor cells has been proposed for tumors of different origins. We have studied IGF gene expression in human uterus smooth muscle (myometrium) and in a panel of benign (leiomyoma) and malignant (leiomyosarcoma) smooth muscle tumors. Using RNA transfer blot analysis we could demonstrate that in smooth muscle tissue and tumors IGF genes are differentially expressed. The mRNA species detected had the same size as reported for IGF mRNAs from other tissues. However, the abundance of the IGF gene transcripts varied from tissue to tissue. The amounts of IGF mRNAs detected in smooth muscle tumors were compared to the levels found in normal smooth muscle. The IGF-I gene was expressed at high levels in normal myometrium and in leiomyomas but appears to be repressed in leiomyosarcomas. Also the IGF-I peptide was detected in myometrium and in leiomyomas, but in leiomyosarcomas the level was substantially lower. The IGF-II gene was expressed at low levels in normal myometrium and leiomyomas but is activated in leiomyosarcomas. With increasing malignancy from the two major IGF-II mRNA species, 6.0 and 4.8 kilobases, in particular the 6.0-kilobase mRNA is produced at higher levels. In conclusion, these data suggest that for IGF-I a role in tumor cell growth is not likely, but probably IGF-II is involved in malignant smooth muscle tumor growth progression.
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PMID:Insulin-like growth factor gene expression in human smooth muscle tumors. 220 34

The 11th case of primary leiomyosarcoma of the renal vein is reported. Unique features of this case included concomitant resection of an isolated hepatic metastasis, intraoperative radiation therapy, and the use of electron microscopy and immunohistochemical stains in confirming the diagnosis. A review of the previously reported cases shows a tendency toward slow tumor growth and infrequent recurrence (18%). Metastases are common (82%), primarily to the lung and liver. Aggressive surgical resection and adjuvant radiation therapy, including intraoperative radiation therapy, are recommended. Adjuvant chemotherapy should be considered, although its benefits at present are unclear.
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PMID:Renal vein leiomyosarcoma. 221 91

The study was concerned with development of parameters to be used in making prognosis of survival in squamous-cell cancer of the skin, fibrosarcoma, malignant fibrous histiocytoma of the bone, leiomyosarcoma, rhabdomyosarcoma, secondary chondrosarcoma, chondroma and osteochondroma. One of them--tumor growth rate--is a maximum tumor size/case history duration ratio (Formula: see text). Other coefficients represent ratios between some characteristics (maximum size or Tt.s) and parameters of a patient's status (height, weight/height ratio, body surface area). A correlation between the suggested coefficients and survival was established.
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PMID:[Clinico-morphological indices for the differential diagnosis and prognosis of the course of a series of malignant tumors]. 282 Jan 46

In malignant cells the amino groups of cellular proteins are alkylated by homocysteine thiolactone, forming homocysteinyl peptide bonds. In normal cells the sulfur atom of homocysteine thiolactone is converted to homocysteic acid, phosphoadenosine phosphosulfate, and sulfate ester. N-substituted derivatives of homocysteine thiolactone synthesized from arachidonic acid, pyridoxal, and maleimide were previously found to have antineoplastic activity. Another N-substituted derivative, the rhodium trichloride complex of oxalyl homocysteine thiolactone, was synthesized and tested for antineoplastic activity. Mice with transplanted rhabdomyosarcoma were injected with solutions of the complex dissolved in lipids. Doses of 50 and 100 mg/kg per day for two weeks produced 50% inhibition of tumor growth. At doses of 100 and 200 mg/kg per day in tumor-free mice there was decreased survival, peritoneal reaction, pigment deposition in lung, fibrocalcific pericarditis, and leiomyosarcoma of colon (in one animal). The conclusion is that the complex of rhodium trichloride and oxalyl homocysteine thiolactone possesses antineoplastic activity.
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PMID:Antineoplastic activity of a rhodium trichloride complex of oxalyl homocysteine thiolactone. 358 Sep 45

The authors describe the occurrence of a confirmed leiomyosarcoma and a tumor suspected of being a leiomyosarcoma in 23-year-old twin sisters. In one of them the tumor had caused clinical symptoms; in the second it was detected at the presymptomatic stage as a result of increased attention after detection of the first tumor. In the first case treatment consisted in an extended abdominal hysterectomy, sparing one ovary, with bilateral interiliac lymph node extirpation; in the second case, in an extended abdominal hysterectomy with both adnexae and bilateral interiliac lymph node extirpation. So far - 13 and 10 months after the initial treatment, respectively - there are no signs of continued tumor growth in either case.
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PMID:[Leiomyosarcoma of the uterus in young identical twins]. 369 35

We report 4 cases of soft tissue sarcoma following radiation therapy for testicular tumor. The tumors included leiomyosarcoma, fibroxanthosarcoma, reticulum cell sarcoma and spindle cell sarcoma. Each malignancy arose within the irradiated area after a long latent period (mean 12 years) and each was histologically proved. Total radiation doses ranged from 3,500 to 9,000 rad. Three patients died as a result of the second neoplasm. Radiation-induced sarcomas are rare but must be considered in the differential diagnosis of new tumor growth in patients treated previously with radiotherapy. Full evaluation of such new tumor growth, including tissue diagnosis, is necessary before additional therapy is prescribed.
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PMID:Radiation-induced sarcoma following radiotherapy for testicular tumor. 703 70

Leiomyosarcoma, a highly malignant tumor of the inferior vena cava, is rare. Only 55 cases have been reported in the world literature, and of these only 18 were evaluated with a special vascular procedure, either arteriography or inferior vena cavography. In two cases of leiomyosarcoma of the inferior vena cava, we performed arteriography and inferior vena cavography. In one, computed tomographic studies were also carried out. Cavography showed a lobulated filling defect in one case and complete caval occlusion with collateral circulation in the other. In the one case in which it was performed, computed tomography clearly demonstrated the tumor's size and its relationship to surrounding organs. Arteriographic studies, however, allowed only an indistinct delineation of the extent of tumor growth in one case. Venography followed by computed tomography should permit adequate assessment of most leiomyosarcomas of the inferior vena cava, with arteriography reserved for tumors involving the upper cava in which hepatic involvement must be evaluated.
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PMID:Leiomyosarcoma of the inferior vena cava: angiographic and computed tomography findings. Report of two cases and review of imaging criteria. 728 59


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