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Query: UMLS:C0598934 (tumor growth)
 58,965 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

By routine histological staining technics and histochemical assays under an appropriate enzymic control the author has studied changes in the basement membranes of the uterine cervix in its precancer and cancer as compared with the normal state. Changes in the basement membranes, revealed morphologically, reflect objectively the status of the epithelium and stroma during the period of tumor origination and growth, and therefore these may serve as a valuable adjunct to the differential microscopic diagnosis of dysplasia, preinvasive cancer and an incipient invasive growth. It is believed that basement membrane neoplasms may develop around mostly differentiated complexes of cancer cells in far-advanced neoplasms and their metastases; this fact is regarded as a tendency to normalization of the relationship between the cancerous tumor parenchyma and stroma with correlations between them being remined even under extremely unfavourable conditions of the tumor growth.
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PMID:[Basement membranes in precancerous conditions and neoplasms of the uterine cervix]. 48 15

The diagnostic difficulties encountered with atypical tumor growth are reported in a 29-year-old female with recurrent carcinoma of the uterine cervix. Following a Wertheim-Meigs procedure and resection of local tumor recurrence eight months later, a second recurrence was detected on CT as a purely cystic lesion in the left pelvic wall. Although the size of the cyst subsequently increased, the patient remained asymptomatic until slight pain developed in the left leg 28 months after initial therapy. One month later, limping was noticed; plain radiography showed a large osteolytic lesion of the left hip and on I.V.U., a dilatation of the left renal collecting system was observed. Pelvic CT showed only minimal solid tissue components within a large cyst. Multiple needle aspirations of the cyst and cytological examinations of the fluid obtained showed no evidence of tumor cells. A definitive histological diagnosis of metastasizing squamous cell carcinoma was only reached after surgery.
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PMID:Cystic pelvic mass in a patient having recurrent carcinoma of the cervix. 231 57

Antitumor efficacies of five antineoplastic agents, cisplatin, mitomycin, doxorubicin, 5-fluorouracil and bleomycin were tested against the human carcinoma of the uterine cervix xenografted into nude mice in order to search for effective combination chemotherapy. Antineoplastic agent was administered i.p. 6 times once a week to nude mice with tumor growing to 8-10 mm in diameter. The effect in each group was evaluated by Battelle Columbus Laboratories' method, measuring at 6th week the tumor growth rate in the treatment group (Tn/T0) and in the control group (Cn/C0) where the comparative tumor growth ratio (Tn/T0/Cn/C0) was taken as the index. As the result, the response rates of cisplatin and mitomycin on the tumor growth were high as 83.3% and 66.7% respectively. It is concluded that combination chemotherapy including cisplatin and mitomycin is recommendable for the treatment of squamous cell carcinoma of the uterine cervix.
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PMID:[Sensitivity of antineoplastic agents in squamous cell carcinoma of the uterine cervix xenografted into nude mice]. 244 95

We investigated antitumor effect of cis-diammine-dichloroplatinum (cisplatin or CDDP), cyclophosphamide (CY) and interferon-gamma (gamma-IFN) against argyrophil small cell carcinoma (ASCC) of the uterine cervix using heterotransplanted ASCC tumor (YIK-1) into nude mice, containing HPV 16 DNA in a multicopy integrated form. No tumor growth retardation was observed in the nude mice which received the single administration of CDDP 2 mg/kg, CY 10 mg/kg or gamma-IFN 1 x 10(7) U/kg. However, the combined administration of CDDP and CY, or CDDP, CY and gamma-IFN markedly inhibited the tumor growth. Moreover, with comparison about relative tumor volume between these two groups, the combination of CDDP, CY and gamma-IFN was more effective than that of CDDP and CY. These data suggest that the combination chemotherapy of CDDP, CY and/or gamma-IFN was effective for the suppression of tumor growth in argyrophil small cell carcinoma of the uterine cervix. Further study on the antitumor potentiation of various anti-cancer agent and the combination of them against ASCC is needed.
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PMID:[Antitumor effects of cisplatin, cyclophosphamide and interferon-gamma (gamma-IFN) against argyrophil small cell carcinoma of the uterine cervix heterotransplanted into nude mice]. 255 73

In the present experiment we attempted to experimentally induce uterine cancer in rats by injecting into the uterine cavity N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) dissolved in polyethylene glycol (PEG). Fifty-nine female F-344 rats, 7-8 weeks old, were divided into three groups and each received in the left uterine cavity with laparotomy a single dose of ENNG dissolved in PEG according to the following schedule: Group 1 received 75 mg ENNG/kg body wt.; Group 2 had 20 mg ENNG/kg body wt.: and Group 3 was given only PEG. In Group 1 it was observed that adenocarcinoma and sarcoma were present in the uterine corpus while squamous cell carcinoma occurred in the uterine cervix. In Group 2, although tumors such as adenocarcinoma, adenoma and sarcoma were observed in the uterine corpus, no tumor was present in the uterine cervix. No tumor growth whatsoever was observed in Group 3. From the above results it is apparent that the present method is an efficient means for experimentally inducing uterine cancer and that the site of tumor generation varies according to the concentration of ENNG administered.
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PMID:Experimental induction of uterine cancer in rats by N-ethyl-N'-nitro-N-nitrosoguanidine dissolved in polyethylene glycol. 279 22

A human squamous cell carcinoma (SCC) of oral origin was transplanted into athymic mice that were then divided into six groups. The mice were killed at 1 to 6 weeks after tumor transplantation; the sixth group was killed 1 week after excision of SCC grafts. Plasma samples were obtained from each mouse at the time of death for the determination of SCC-associated antigen (SCCAA), a cytoskeletal protein fraction of about 48,000 daltons originally derived from SCC of the uterine cervix. The plasma SCCAA level rose gradually and proportionately to the growth of SCC xenografts from a baseline of 0.66 ng/ml [standard error (SE) + 0.12] to the preoperative peak of 8.44 ng/ml (SE + 1.86) at 5 weeks, to fall precipitously to the postoperative level of 1.05 ng/ml (SE + 0.27) at 6 weeks. No rise in plasma SCCAA level was observed in mice bearing a human malignant melanoma, and only modest rises were observed in mice bearing human adenocarcinomas and oat cell carcinoma. In this experimental model rising plasma SCCAA levels were found to be dependable indicators of SCC tumor growth. These observations and preliminary data on SCCAA levels in patients with or without SCC of the head and neck lend support to the clinical usefulness of serial plasma SCCAA determinations in monitoring patients with SCC of the oral cavity.
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PMID:Plasma levels of a squamous cell carcinoma-associated antigen in athymic nude mice bearing human squamous cell carcinoma xenografts of oral origin. With preliminary clinical data. 317 44

A regression of tumor growth is observed when alkoxyglycerols are administered prior to radiation treatment of patients suffering from cancer of the uterine cervix. This regression is remarkably higher for patients below the age of 60 years than for those over 60. The regression has been demonstrated by a change in the quotient between the incidence of early and advanced stages.
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PMID:Reduced mortality in cancer patients after administration of alkoxyglycerols. 354 64

A comparative study has been made on the levels of vitamins A and C in normal and malignant conditions in human and murine subjects. Further, the effect of supplemental vitamins A and C on tumor take, host-survival and tumor growth have been studied in a number of transplantable and induced tumors in mice. The vitamins were assayed in sera samples from normal subjects, patients with cancer of the uterine cervix or ovary, and leukemia and lymphoma patients. Among the murine group the tumors included sarcoma 180 in solid and ascitic form, benzo[a]pyrene-induced fibrosarcoma, Dalton's ascitic lymphoma and Schwartz lymphoblastic leukemia. The serum level of vitamin C was found to be lower than that of the normal controls in all cases studied. The level of vitamin A was found to be higher in cancer patients in the human group and lower in the murine group when compared with their normal controls. Studies on murine tumors showed that supplementary vitamins administered at the initial phase of tumor development reduced the percentage tumor take and the rate of tumor growth, and improved host survival, indicating that these vitamins have a protective role in the murine system.
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PMID:Evaluation of vitamin A and C status in normal and malignant conditions and their possible role in cancer prevention. 393 31

Enhanced nucleocytoplasmic RNA transport has been demonstrated by incubating normal rat liver nuclei in presence of cytosols originating from the poorly differentiated, fast-growing hepatoma HW-165, in the linear phase of tumor growth. The effect of hepatoma HW-165 cytosol was reduced or suppressed in presence of small amounts of normal liver cytosol: on the other hand, several polypeptides of molecular weight 20,000 to 40,000 daltons were hardly detectable in hepatoma HW-165 cytosol, both arguments indicating that potentially regulatory proteins should be absent or present in reduced concentration in hepatoma HW-165 cytosol. No modification of RNA release was observed in presence of cytosols originating from the thymus of RNA virus (BL/F)-infected rats, whatever be the time after inoculation. Attempts were made to use the nuclear restriction assay, supplemented with plasma or serum of various origins, as a biochemical marker of neoplasia. In a first series of assays, including 80 cancer patients and 12 healthy controls, the RNA transport activity was stimulated by the serum of patients bearing various tumors (lung cancer, cancer of the respiratory tract, uterine cervix...), except in a few cases of mammary carcinoma, where values equivalent to or lower than the controls were obtained.
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PMID:On the altered nucleocytoplasmic transport "in vitro" of rapidly labelled RNA, in the presence of cytosol or serum from tumor-bearing rats. 616 10

The effects of an anabolic steroid on the immune activity and clinical condition of patients with cancer of the uterine cervix were studied. The effects of the steroid on tumor growth were also studied in animals. The results obtained demonstrated that the anabolic steroid (1) enhanced the activity of macrophages and cell-mediated immune activity, (2) reduced the incidence of post-operative infection, (3) reduced pose-operative loss of weight of patients due to the intrinsic anabolic activity of the steroid, and (4) did not exert any influence on tumor growth. Judging from these results, administration of the anabolic steroid would appear to be effective for the improvement of the general condition of cancer patients following surgery or in terminal cases.
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PMID:[Effect of an anabolic steroid on the cellular immunity and postoperative evaluation of uterine cervical cancer]. 648 33


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