Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0598853 (forgetting)
 3,232 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of this study was to examine memory bias for disorder-relevant information in anorexia nervosa by using the directed forgetting paradigm. Normal controls and patients with anorexia nervosa were given a list consisting of neutral and disorder-relevant words, which they were either asked to remember (R) or forget (F). Memory performance was measured by a free recall and a Yes/No recognition task for all items. There was a directed forgetting effect for both groups; however, the magnitude of the effect (difference between R and F words) was smaller for the patient group due to higher recall of F items. Further analyses showed that this was true only for disorder-relevant but not for neutral items. Our findings support the existence of a strong memory bias for disorder-relevant information in patients with anorexia nervosa, who had difficulty in avoiding the processing of information that they were asked to forget.
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PMID:Memory bias in anorexia nervosa: evidence from directed forgetting. 1799 15

Transient epileptic amnesia (TEA) is an epileptic syndrome characterized by recurrent, brief episodes of amnesia. Transient epileptic amnesia is often associated with the rapid decline in recall of new information over hours to days (accelerated long-term forgetting - 'ALF'). It remains unknown how recognition memory is affected in TEA over time. Here, we report a systematic study of picture recognition in patients with TEA over the course of one week. Sixteen patients with TEA and 16 matched controls were presented with 300 photos of everyday life scenes. Yes/no picture recognition was tested 5min, 2.5h, 7.5h, 24h, and 1week after picture presentation using a subset of target pictures as well as similar and different foils. Picture recognition was impaired in the patient group at all test times, including the 5-minute test, but it declined normally over the course of 1week. This impairment was associated predominantly with an increased false alarm rate, especially for similar foils. High performance on a control test indicates that this impairment was not associated with perceptual or discrimination deficits. Our findings suggest that, at least in some TEA patients with ALF in verbal recall, picture recognition does not decline more rapidly than in controls over 1week. However, our findings of an early picture recognition deficit suggest that new visual memories are impoverished after minutes in TEA. This could be the result of deficient encoding or impaired early consolidation. The early picture recognition deficit observed could reflect either the early stages of the process that leads to ALF or a separable deficit of anterograde memory in TEA. Lastly, our study suggests that at least some patients with TEA are prone to falsely recognizing new everyday visual information that they have not in fact seen previously. This deficit, alongside their ALF in free recall, likely affects everyday memory performance.
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PMID:Impaired picture recognition in transient epileptic amnesia. 2550 93