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Query: UMLS:C0598853 (forgetting)
 3,232 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Classical human memory studies investigating the acquisition of temporally-linked events have found that the memories for two events will interfere with each other and cause forgetting (i.e., interference; Wixted, 2004). Importantly, sleep helps consolidate memories and protect them from subsequent interference (Ellenbogen, Hulbert, Stickgold, Dinges, & Thompson-Schill, 2006). We asked whether sleep can also repair memories that have already been damaged by interference. Using a perceptual learning paradigm, we induced interference either before or after a consolidation period. We varied brain states during consolidation by comparing active wake, quiet wake, and naps with either non-rapid eye movement sleep (NREM), or both NREM and REM sleep. When interference occurred after consolidation, sleep and wake both produced learning. However, interference prior to consolidation impaired memory, with retroactive interference showing more disruption than proactive interference. Sleep rescued learning damaged by interference. Critically, only naps that contained REM sleep were able to rescue learning that was highly disrupted by retroactive interference. Furthermore, the magnitude of rescued learning was correlated with the amount of REM sleep. We demonstrate the first evidence of a process by which the brain can rescue and consolidate memories damaged by interference, and that this process requires REM sleep. We explain these results within a theoretical model that considers how interference during encoding interacts with consolidation processes to predict which memories are retained or lost.
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PMID:REM sleep rescues learning from interference. 2549 22

Relational memories are formed from shared components between directly learned memory associations, flexibly linking learned information to better inform future judgments. Sleep has been found to facilitate both direct associative and relational memories. However, the impact of incorporating emotionally salient information into learned material and the interaction of emotional salience and sleep in facilitating both types of memory is unknown. Participants encoded two sets of picture pairs, with either emotionally negative or neutral objects paired with neutral faces. The same objects were present in both sets, paired with two different faces across the sets. Baseline memory for these directly paired associates was tested immediately after encoding, followed by either a 90-min nap opportunity or wakefulness. Five hours after learning, a surprise test assessed relational memory, the indirect association between two faces paired with the same object during encoding, followed by a retest of direct associative memory. Overall, negative information was remembered better than neutral for directly learned pairs. A nap facilitated both preservation of direct associative memories and formation of relational memories, compared to remaining awake. Interestingly, however, this sleep benefit was observed specifically for neutral directly paired associates, while both neutral and negative relational associations benefitted from a nap. Finally, REM sleep played opposing roles in neutral direct and relational associative memory formation, with more REM sleep leading to forgetting of direct associations but promoting relational associations, suggesting that, while not benefitting memory consolidation for directly learned details, REM sleep may foster the memory reorganization needed for relational memory.
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PMID:The differential effects of emotional salience on direct associative and relational memory during a nap. 2767 Feb 88

Although there is a wide consensus on how sleep processes declarative memories, how sleep affects emotional memories remains elusive. Moreover, studies assessing the long-term effect of sleep on emotional memory consolidation are scarce. Studies testing subclinical populations characterized by REM abnormalities are also lacking. Here we aimed to (i) investigate the fate of emotional memories and the potential unbinding (or preservation) between content and affective tone over time (i.e., 1 week), (ii) explore the role of seven nights of sleep (recorded via actigraphy) in emotional memory consolidation, and (iii) assess whether participants with self-reported mild-moderate depressive symptoms forget less emotional information compared to participants with low depression symptoms. We found that, although at the immediate recognition session emotional information was forgotten more than neutral information, a week later it was forgotten less than neutral information. This effect was observed both in participants with low and mild-moderate depressive symptoms. We also observed an increase in valence rating over time for negative pictures, whereas perceived arousal diminished a week later for both types of stimuli (unpleasant and neutral); an initial decrease was already observable at the immediate recognition session. Interestingly, we observed a negative association between sleep efficiency across the week and change in memory discrimination for unpleasant pictures over time, i.e., participants who slept worse were the ones who forgot less emotional information. Our results suggest that emotional memories are resistant to forgetting, particularly when sleep is disrupted, and they are not affected by non-clinical depression symptomatology.
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PMID:The Fate of Emotional Memories Over a Week: Does Sleep Play Any Role? 3089 Sep 91


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