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Query: UMLS:C0598853 (forgetting)
 3,232 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

With the increasing demand on phenotyping of mouse mutants there is a clear need to develop novel paradigms for testing mice. Mice are able to learn a non-matching to position rule to high accuracy in a variety of maze paradigms, but an operant version of this task is desirable. In the present study, mice of the C57BL/6 and DBA/2 strains were trained and tested on an operant delayed non-matching to position (DNMTP) paradigm. Data were analysed according to the methods of signal detection theory (SDT), which allows conclusions as to whether strain differences in DNMTP performance are more related to changes in accuracy or in motivational factors. Mice can learn to respond on an operant DNMTP paradigm with high accuracy, and accurate performance depends on the duration of the delay-period, i.e. forgetting curves can be generated. Comparison between the two strains of mice revealed that DBA/2 mice learned faster than C57BL/6 mice to associate the lever press with food during initial shaping, but no further strain differences were observed in accurate responding during later stages of the experiment. However, differences in biased responding and, in particular, responsivity were observed between the two strains. Muscarinic blockade with scopolamine (0.1--1.0 mg/kg) failed to affect accuracy in the two strains, but altered responsivity. This task should be of great value for a more in-depth analysis of cognitive function in mutant mice as it allows a better dissociation between mnemonic and non-mnemonic factors. In particular, such paradigm may be of interest for testing conditional mutants, which allow time-sensitive induction or inhibition of gene expression, i.e. where animals can be trained while non-impaired to stable baseline and then tested once the gene is activated or inhibited.
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PMID:Effects of cholinergic manipulation on operant delayed non-matching to position performance in two inbred strains of mice. 1127 83

Studies describing variations in fear-related memory in inbred mouse strains typically focus upon 24 h retention. As a consequence, little is known about strain differences in the establishment of longer lasting memories of aversive events. In the present study, male mice from the strains A/Ibg, AKR/J, BALB/cByJ, CBA/J, C3H/HeIbg, C57BL/6J, DBA/2J, LP/J, SJL/J and 129/SvevTac were tested 24 h, 14, or 60 days after contextual and auditory-cued fear conditioning. Consistent with previous data, 24 h after conditioning these strains exhibited substantial variation in levels of memory for the context and the auditory cue as measured by freezing scores. Sixty days after training, most strains exhibited some forgetting of the context and auditory cue, and again there was significant strain variation. Strain rankings at 60-day retention were similar to that at 24 h with a significant genetic correlation between freezing values for the two time periods. Fourteen days following training, nearly all strains exhibited generalized freezing, a behavioral phenotype originally observed in C57BL/6 but not DBA/2 mice. These data confirm that cognitive differences exist between several popular inbred mouse strains during 24 h contextual fear recall. In addition, they extend these differences into retention time frames longer than those typically used and reveal several unique learning profiles of mouse strains that may be useful in furthering our understanding of how memories are formed. Emotionally arousing situations are often recalled a great deal of time after an event. Therefore, a more complete picture of the biochemical and genetic underpinnings of learning and memory will benefit from studies using time points that assess time points beyond 24 h retention. The utility of the 14-day hyper responsiveness phenotype as a potential model for fear-related psychopathology is also discussed.
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PMID:Inbred mouse strain differences in the establishment of long-term fear memory. 1264 83