Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0598853 (forgetting)
 3,232 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The present study was designed to investigate the effect of i.c.v. administration of various muscarinic receptor antagonists in rats on memory performance in delayed non-matching to position test. The drugs chosen were the non-selective antagonist scopolamine (3 and 10 micrograms), the muscarinic M1 receptor-selective antagonist pirenzepine (10 and 30 micrograms) and the muscarinic M2 receptor-selective antagonist methoctramine (2, 5 and 20 micrograms). Scopolamine delay-independently decreased % correct choices and reduced motor activity. Pirenzepine also delay-independently decreased % correct choices. In contrast, methoctramine 2 micrograms, but not at 5 or 20 micrograms, improved slightly, but significantly, % correct performance delay-dependently. The present data suggests that the decrease in activation of inhibitory muscarinic M2 autoreceptors induced by methoctramine produces a specific improvement of short-term memory at long forgetting delays.
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PMID:Methoctramine moderately improves memory but pirenzepine disrupts performance in delayed non-matching to position test. 931 25