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Pivot Concepts:
Gene/Protein
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Target Concepts:
Gene/Protein
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Query: UMLS:C0598853 (
forgetting
)
3,232
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The authors studied the role of
gamma-aminobutyric acid
(
GABA
) in 2 types of
forgetting
of fear in the developing rat. One type of
forgetting
studied was that observed after an intermediate retention interval (the "Kamin effect"); the other type studied was that observed after a longer interval (infantile amnesia). Rats were given pairings of an auditory conditioned stimulus with shock, and learned fear was assessed by freezing.
Forgetting
at an intermediate retention interval (1 hr) was not alleviated by the
GABA
-sub(A) receptor partial inverse agonist FG7142 (0, 1, 5, or 10 mg/kg), whereas
forgetting
at a longer retention interval (48 hr) was alleviated. These results suggest that in the developing rat,
forgetting
observed at different retention intervals is mediated by different physiological mechanisms.
...
PMID:The effects of FG7142 on two types of forgetting in 18-day-old rats. 1808 96
