Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0598853 (forgetting)
 3,232 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Following 2 h of unrestricted access to a black and a white arm of a Y maze, 8-month-old "adult" and 21-month-old "middle-aged" rats were injected intraperitoneally with 0 (vehicle), 50 or 100 mg/kg D-glucose. Twenty-four hours later they were allowed free access to two black arms. When treated with vehicle, there was no evidence of any memory for change as determined by first and total entries of, and time spent in the changed arm. However, the adult "younger" rats showed significant awareness of the changed arm following treatment with the higher dose of glucose. It was concluded that, for adult rats only, treatment with glucose prevented forgetting of their pretreatment experience with the maze arms thereby enabling detection and choice of the changed alternative. It was also suggested that the experimental procedure might have potential as a measure of memory, in particular, one not dependent on deprivation and reinforcement, in the absence of current effects of glucose or other enhancing agents.
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PMID:Prevention of memory loss for a brightness change in adult and middle-aged rats by postacquisition treatment with glucose. 1367 24

A 44-year-old woman presented with focal retrograde amnesia and complaints of rapid forgetting in the absence of episodes of transient cognitive disturbance. Her MRI and 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (FDG-PET) were normal. On standard neuropsychological tests she performed within the normal range although a test of autobiographical memory confirmed impoverished recall especially involving recent life events. The electroencephalograph (EEG) recordings were suggestive of temporal lobe epilepsy but no clear diagnosis was established. After 4 years the patient's recurrent brief episodes of disorientation, suggestive of transient epileptic amnesia (TEA), were corroborated by her sister. This diagnosis was confirmed by an ambulatory EEG that revealed ictal activity. Several important points emerge from this study. Focal retrograde amnesia can be a prodromal symptom of TEA which can precede the full-blown syndrome by several years. Moreover, transient attacks might not be reported if patients live alone. The ictal EEG findings further substantiate the epileptic nature of the syndrome.
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PMID:Focal retrograde amnesia: Extending the clinical syndrome of transient epileptic amnesia. 2059 90