Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0598853 (
forgetting
)
3,232
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Synapses between engram cells are believed to be substrates for memory storage, and the weakening or loss of these synapses leads to the
forgetting
of related memories. We found engulfment of synaptic components by microglia in the hippocampi of healthy adult mice. Depletion of microglia or inhibition of microglial phagocytosis prevented
forgetting
and the dissociation of engram cells. By introducing
CD55
to inhibit complement pathways, specifically in engram cells, we further demonstrated that microglia regulated
forgetting
in a complement- and activity-dependent manner. Additionally, microglia were involved in both neurogenesis-related and neurogenesis-unrelated memory degradation. Together, our findings revealed complement-dependent synapse elimination by microglia as a mechanism underlying the
forgetting
of remote memories.
...
PMID:Microglia mediate forgetting via complement-dependent synaptic elimination. 3280 74
