Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0598853 (
forgetting
)
3,232
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
There are conflicting reports on the influence of
thyrotropin-releasing hormone
(
TRH
) on the process of learning. We decided to study this problem using the paradigm of classical eyeblink conditioning as the animal model of learning processes. During the extinction training
TRH
in its natural form of pG1uTRH was applied into the rabbit hippocampus through a chronically implanted microdialysis probe. A Glu(1)
TRH
, analog with less biological potency than
TRH
as the control of specificity for
TRH
and a 0.9% NaCl solution as the control for both substances were applied by the same way as pGluTRH. We found that pGluTRH extended the process of extinction and enhanced the further acquisition of the reflex. The analog of
TRH
, Glu(1)
TRH
, was ineffective. Finally, it may be stated that
TRH
acting in the hippocampus prolonged process of
forgetting
and improved succeeding learning. The effect was specific and long lasting.
...
PMID:Influence of thyrotropin-releasing hormone (TRH) dialyzed into the hippocampus on memory processes in rabbit. 1747 21
