Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0598766 (leukemogenesis)
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Human Gene/Protein
BCL-3-binding protein 12.9
myotubularin related protein 11 12.9
GOLGA6 12.9
PHF23 protein 12.9
adaptor-related protein complex 4, beta 1 subunit 12.9
IQ motif containing G 12.9
CLLD8 11.9
RNF130 11.9
MLL-AF4 fusion protein 11.9
CLLD7 11.9
GKAP1 11.9
LTG9 11.9
FOXD4a 11.9
KARCA1 11.9
AIF1L 11.9
Ras-like without CAAX 1 11.9
enhancer of polycomb 1 11.9
C10orf53 11.9
IBRDC2 11.9
C9orf103 11.9
ELL associated factor 1 11.9
SCLL 11.9
RNA binding motif protein 15 11.9
PROCA1 11.9
SETD3 protein 11.9
CALM/AF10 fusion 11.8
E2A/HLF 11.6
ankyrin repeat domain 28 11.4
H2.0-like homeobox 1 11.4
PMX1 11.4
KRBA2 11.4
KIAA1546 11.4
proline-rich acidic protein 11.4
HOX B6 11.4
TNG2 11.4
Ari2 11.4
FOXD4b 11.4
FLJ10374 11.4
nucleoporin NUP98 11.4
interferon-inducible double-stranded RNA-dependent protein kinase 11.4
more...
Disease
FIM1 12.9
leukemogenesis 12.9
AML with recurrent genetic abnormality 12.9
viral leukemogenesis 11.3
HPC3 10.9
Therapy-related acute myeloid leukemia and myelodysplastic syndrome 10.9
dual addiction 10.6
CMML-2 10.1
radiation leukemia 9.9
FPD/AML 9.8
CMML-1 9.8
AML progression 9.7
FAB M4Eo 9.5
bone marrow cancer 9.4
DSCR 9.4
Leukemia stem cell 9.1
CEBPG 9.0
pediatric AML 8.9
Gingival hypertrophy 8.8
megakaryocytic leukemia 8.7
GPHN 8.7
monosomy 7q 8.7
T-cell acute lymphoblastic leukemia 8.7
Ph-positive acute lymphoblastic leukemia 8.5
Leukemia relapse 8.5
Friend leukemia 8.5
juvenile myelomonocytic leukemia 8.4
myeloid leukemia 8.4
severe congenital neutropenia 8.4
B-ALL 8.3
adult AML 8.3
acute myeloid leukemia 8.2
RAEB-2 8.2
congenital amegakaryocytic thrombocytopenia 8.2
AUTS2 8.2
T-cell prolymphocytic leukemia 8.1
X-linked severe combined immunodeficiency 8.0
atypical chronic myeloid leukemia 8.0
Trisomy 12 8.0
FAIDS 8.0
more...
Symptom
splenomegaly 4.6
hepatosplenomegaly 4.3
loss of balance 4.1
ataxic gait 3.8
nasal congestion 2.8
bone pain 2.3
hepatomegaly 1.4
starvation 1.3
exhaustion 1.2
cachexia 0.5
hypotonia 0.4
erythema -0.7
respiratory distress -1.3
overweight -1.8
dyspnea -1.8
weakness -2.3
fatigue -2.7
headache -2.8
Drug
TEL 9.4
Lestaurtinib 9.2
Dacogen 8.5
Purvalanol 8.4
Anagrelide 7.5
MDS 7.0
Midostaurin 7.0
Azacytidine 6.4
Gleevec 6.4
Mizoribine 6.3
Imatinib 6.2
ETS 6.2
Intron A 6.1
ARA-C 6.1
Methylcellulose 6.1
Intron A 5.9
Intron A 5.9
EML 5.5
Arsenic trioxide 5.2
Etoposide 5.1
Anakinra 5.0
RAL 5.0
CDX 4.9
ID2 4.8
Dasatinib 4.7
G-CSF 4.7
CDX 4.5
AraC 4.5
Retinoic acid 4.4
Retinoic Acid 4.4
MDM 4.2
Norplant 4.2
NVP 4.0
G418 3.8
RFP 3.7
Isotretinoin 3.5
Trib 3.5
CSF 3.4
MOF 3.4
Florisil 3.3
more...
Enzyme
dihydrolipoamide succinyltransferase 6.8
EC 4.4.1.5 6.7
lysine acetyltransferase 6.4
factor C 6.4
histone acetyltransferase 6.0
SLB 5.7
Rex 5.7
jararhagin 5.6
TGT 5.5
PHD 5.5
Lys4 5.5
DNA methyltransferase 5.5
thiopurine methyltransferase 5.4
focal adhesion kinase 5.2
Protein 2 5.2
sphingomyelin synthase 5.1
caspase-6 5.0
caspase-6 5.0
p80 4.8
CD13 4.8
topoisomerase 4.7
p100 4.7
topoisomerase 4.6
Fpg protein 4.5
isocitrate dehydrogenase 4.5
FPS 4.5
oxidosqualene cyclase 4.5
sphingosine kinase 4.4
CEP 4.4
protein phosphatase 2A 4.4
isocitrate dehydrogenase 4.4
ERK 4.3
xylose isomerase 4.3
dUTPase 4.3
CGT 4.1
demethylase 4.1
TdT 4.1
histone demethylase 4.1
alpha-L-fucosidase 4.0
phosphatidylinositol 3-kinase 4.0
more...
Compound
TEL 9.4
N-butylurea 8.7
KTS 7.8
Bisdemethoxycurcumin 7.8
KT-1 7.5
TKB 7.5
Benzene 7.3
ABL 7.2
BCR 7.2
Pyran 7.1
ara-AMP 7.0
ara-AMP 7.0
DEK 6.9
Rifamycin 6.8
1,2,4-benzenetriol 6.8
TLL 6.7
MHT 6.7
Deguelin 6.6
Rifamycin 6.6
Rifamycin 6.5
Homoharringtonine 6.4
SC-1 6.4
SC-1 6.3
hydroxyglutarate 6.3
1,3-Butadiene 6.2
E-4031 6.1
5-Aza-2'-deoxycytidine 6.0
HMBA 6.0
CAN 6.0
TET 5.9
TET 5.9
SET 5.9
Rifamycin 5.9
CD 3 5.8
TGT 5.8
HMBA 5.6
DCL 5.6
DOA 5.6
NFS 5.5
DAM 5.5
more...