Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0598766 (leukemogenesis)
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Human Gene/Protein
GOLGA6 12.9
BCL-3-binding protein 12.9
IQ motif containing G 12.9
adaptor-related protein complex 4, beta 1 subunit 12.9
myotubularin related protein 11 12.9
PHF23 protein 12.9
LTG9 11.9
GKAP1 11.9
RNF130 11.9
SCLL 11.9
CLLD8 11.9
C10orf53 11.9
PROCA1 11.9
FOXD4a 11.9
RNA binding motif protein 15 11.9
ELL associated factor 1 11.9
AIF1L 11.9
Ras-like without CAAX 1 11.9
enhancer of polycomb 1 11.9
C9orf103 11.9
MLL-AF4 fusion protein 11.9
KARCA1 11.9
IBRDC2 11.9
SETD3 protein 11.9
CLLD7 11.9
CALM/AF10 fusion 11.8
E2A/HLF 11.6
ELL-associated factor 1 11.4
interferon-inducible double-stranded RNA-dependent protein kinase 11.4
chromobox homolog 8 11.4
Ari2 11.4
proline-rich acidic protein 11.4
KIAA1546 11.4
T-cell leukemia/lymphoma 6 11.4
PMX1 11.4
CLLD6 11.4
MTG8 protein 11.4
FOXD4b 11.4
FLJ10374 11.4
MLL-TET1 11.4
nucleoporin NUP98 11.4
KRBA2 11.4
H2.0-like homeobox 1 11.4
ankyrin repeat domain 28 11.4
HOMER3 11.4
SSP29 11.4
TNG2 11.4
HNRPK 11.4
CEBPA protein 11.4
synaptotagmin-like 1 11.4
PRPF40B 11.4
HOX B6 11.4
SYTL1 11.4
C20orf112 11.4
MLL protein 11.2
MLL/MEN 11.2
ETV6 protein 11.1
HLF protein 11.1
RBM15 protein 10.9
HALR 10.9
cell division cycle associated 2 10.9
AF4/FMR2 family, member 1 10.9
FLT2 10.9
ZNFN1A1 10.9
EVE1 10.9
PTPLAD2 10.9
DNAH14 10.9
D6Mm5e 10.9
RERGL 10.9
CCDC28A 10.9
MTMR11 10.9
HBZ protein 10.8
AML1/MDS1 10.8
PHF23 10.8
ARIH2 10.8
hepatic leukemia factor 10.8
AHI-1 10.8
SMMHC 10.7
meningioma 1 10.7
CDX4 10.7
monocytic leukemia zinc finger protein 10.7
EEN 10.6
ZNFN1A3 10.6
MED24 10.6
TAPT1 10.6
neuroepithelial cell transforming gene 1 10.6
TRIM45 10.6
CRLF3 10.6
RABGAP1L 10.6
PYGO1 10.6
GKAP42 10.6
GBX1 10.6
BCL2-associated transcription factor 1 10.6
C9orf64 10.6
LEUTX 10.6
ARHGAP20 10.6
AF9 10.6
EAF1 10.5
DDX10 10.5
SET binding protein 1 10.5
TML1 10.5
myeloid/lymphoid or mixed-lineage leukemia 10.5
SALL4B 10.5
Evi-1 10.5
CEBPZ 10.4
CBF-beta 10.4
AF1q 10.4
CREBL2 10.4
ABL1 protein 10.4
SERP2 10.4
Nomo 10.4
Lymphoid-specific helicase 10.4
NEDD5 10.4
CBFB 10.3
AF10 10.3
NUP98 10.3
HOXA9 10.3
CBL-B 10.2
MEIS1 10.2
EVI1 10.2
dihydrolipoamide S-succinyltransferase 10.1
RanBP17 10.1
E1A-associated protein p300 10.1
TRA@ 10.1
KIF27 10.1
SNUPN 10.1
ANKRD28 10.1
LIN28B protein 10.1
LPXN 10.1
TCL6 10.1
FLT3 receptor tyrosine kinase 10.1
ETO 10.1
MTGR1 10.0
MTCP-1 10.0
ABI-1 10.0
AF17 10.0
MTCP1 10.0
HOX11 10.0
CGR19 9.9
TRIAD1 9.9
RBAK 9.9
CDC2L5 9.9
interleukin 2 receptor gamma chain 9.9
Tetraspanin-7 9.9
AML1 9.9
BCR/ABL fusion protein 9.9
LAF4 9.9
HRX 9.9
CHAF1B 9.8
MLL 9.8
AF5q31 9.8
DOT1L 9.8
BRDG1 9.8
MDS1 9.8
PRPF40A 9.8
PHP2 9.8
AIOLOS 9.8
PBX2 9.8
FOXN2 9.8
neural precursor cell expressed, developmentally down-regulated 9 9.8
more...
Disease
AML with recurrent genetic abnormality 12.9
FIM1 12.9
leukemogenesis 12.9
viral leukemogenesis 11.3
Therapy-related acute myeloid leukemia and myelodysplastic syndrome 10.9
HPC3 10.9
dual addiction 10.6
CMML-2 10.1
radiation leukemia 9.9
FPD/AML 9.8
CMML-1 9.8
AML progression 9.7
FAB M4Eo 9.5
bone marrow cancer 9.4
DSCR 9.4
Leukemia stem cell 9.1
CEBPG 9.0
pediatric AML 8.9
Gingival hypertrophy 8.8
megakaryocytic leukemia 8.7
monosomy 7q 8.7
GPHN 8.7
T-cell acute lymphoblastic leukemia 8.7
Ph-positive acute lymphoblastic leukemia 8.5
Leukemia relapse 8.5
Friend leukemia 8.5
juvenile myelomonocytic leukemia 8.4
myeloid leukemia 8.4
severe congenital neutropenia 8.4
B-ALL 8.3
adult AML 8.3
acute myeloid leukemia 8.2
RAEB-2 8.2
AUTS2 8.2
congenital amegakaryocytic thrombocytopenia 8.2
T-cell prolymphocytic leukemia 8.1
X-linked severe combined immunodeficiency 8.0
atypical chronic myeloid leukemia 8.0
Trisomy 12 8.0
FAIDS 8.0
childhood ALL 8.0
refractory CML 7.9
adult T-cell leukemia/lymphoma 7.8
secondary AML 7.8
acute undifferentiated leukemia 7.8
CLL progression 7.8
lymphoblastic leukemia 7.8
childhood ANLL 7.7
Leukemia 7.7
acute leukemia 7.7
bovine leukemia 7.7
CML progression 7.6
trisomy 8 7.6
chronic myelomonocytic leukemia 7.6
ABL 7.6
acute lymphoblastic leukemia 7.6
chronic eosinophilic leukemia 7.6
FAB M2 7.6
pediatric APL 7.6
FAB M1 7.5
myeloproliferative disorders 7.5
T-cell lymphocytosis 7.5
leukemia 7.4
acute promyelocytic leukemia 7.4
acute monocytic leukemia 7.4
PML 7.4
preneoplastic state 7.3
RAEB-1 7.3
MDS/MPD 7.3
FAB M4 7.2
FDC 7.2
LGL leukemia 7.2
APL 7.2
adult ALL 7.1
TMD 7.1
APL 7.1
myelodysplastic syndrome 7.0
trisomy 15 7.0
AML/MDS 7.0
chronic phase CML 7.0
platelet disorder 7.0
congenital anemia 6.9
TRPS1 6.9
HPC1 6.9
MDS 6.9
chronic myeloid leukemia 6.8
B-cell chronic lymphocytic leukemia 6.8
erythroleukemia 6.7
blast crisis 6.7
retroviral disease 6.7
chronic leukemia 6.7
trisomy X 6.6
monosomy 18p 6.6
trisomy 2 6.5
ASG 6.5
Philadelphia chromosome positive 6.5
radiation carcinogenesis 6.5
trisomy 22 6.5
Clonal evolution 6.5
leukemoid reaction 6.5
HTLV-I 6.4
NK-cell leukemia 6.4
RAEB-T 6.4
trisomy 9 6.4
Hypereosinophilia 6.4
LEOPARD syndrome 6.3
RARS 6.3
APL 6.3
minimal residual disease 6.3
acute nonlymphocytic leukemia 6.3
blood cancer 6.2
secondary myelofibrosis 6.2
trisomy 1q 6.2
African Burkitt's lymphoma 6.2
monocytic leukemia 6.2
lymphoid neoplasm 6.2
hematologic malignancies 6.2
monosomy 21 6.2
Burkitt-like lymphoma 6.2
MSF 6.1
malignant state 6.1
CAN 6.1
trisomy 6.1
HRS 6.0
erythroblastosis 6.0
FRAXE 6.0
viral carcinogenesis 6.0
refractory anemia 5.9
epithelial thymoma 5.9
Strongyloides stercoralis infection 5.9
hematological abnormality 5.8
Jacobsen syndrome 5.8
lymphosarcoma 5.8
cancer angiogenesis 5.8
early disease onset 5.8
FBL 5.8
Hypereosinophilic syndrome 5.8
chronic lymphocytic leukemia 5.7
FUS 5.7
Klippel-Trenaunay syndrome 5.7
Jaagsiekte 5.7
FIM 5.7
Fibrodysplasia ossificans progressiva 5.6
Meningioma 5.6
Meningioma 5.6
chronic lymphocytic leukemia 5.5
FHL2 5.5
Fanconi 5.5
chronic neutrophilic leukemia 5.5
WT1 5.4
MEN1 5.4
prolymphocytic leukemia 5.4
childhood cancer 5.4
HPC 5.4
CAPA 5.4
Plasmablastic lymphoma 5.4
neoplastic transformation 5.4
AT3 5.3
AT3 5.3
AT3 5.3
more...
Symptom
splenomegaly 4.6
hepatosplenomegaly 4.3
loss of balance 4.1
ataxic gait 3.8
nasal congestion 2.8
bone pain 2.3
hepatomegaly 1.4
starvation 1.3
exhaustion 1.2
cachexia 0.5
hypotonia 0.4
erythema -0.7
respiratory distress -1.3
overweight -1.8
dyspnea -1.8
weakness -2.3
fatigue -2.7
headache -2.8
Drug
TEL 9.4
Lestaurtinib 9.2
Dacogen 8.5
Purvalanol 8.4
Anagrelide 7.5
MDS 7.0
Midostaurin 7.0
Azacytidine 6.4
Gleevec 6.4
Mizoribine 6.3
Imatinib 6.2
ETS 6.2
Intron A 6.1
ARA-C 6.1
Methylcellulose 6.1
Intron A 5.9
Intron A 5.9
EML 5.5
Arsenic trioxide 5.2
Etoposide 5.1
Anakinra 5.0
RAL 5.0
CDX 4.9
ID2 4.8
Dasatinib 4.7
G-CSF 4.7
CDX 4.5
AraC 4.5
Retinoic acid 4.4
Retinoic Acid 4.4
MDM 4.2
Norplant 4.2
NVP 4.0
G418 3.8
RFP 3.7
Isotretinoin 3.5
Trib 3.5
CSF 3.4
MOF 3.4
Florisil 3.3
lysine 3.0
p75 3.0
Luteinizing 2.9
IL-11 2.8
CDP 2.7
Mutagen 2.7
TAT 2.7
DPA 2.6
CCL 2.6
NBT 2.6
Lovastatin 2.6
IL-1ra 2.5
IL-2 2.5
CTA 2.5
BH4 2.4
GEO 2.3
TAC 2.3
MRC 2.2
niacin 2.1
DNase I 1.9
Paraffin 1.8
Alliance 1.5
AZT 1.5
Asn 1.4
AZT 1.4
Heme 1.3
MAP 1.3
ADM 1.3
CTX 1.2
Adriamycin 0.8
ROS 0.7
Angiotensin II 0.6
Glutathione 0.5
ICI 0.5
CAM 0.4
NH3 0.2
IFN-gamma 0.1
NADH 0.1
ROC 0.0
ampicillin -1.1
Leaf -1.5
ascorbate -1.6
Monit -2.2
Enzyme
dihydrolipoamide succinyltransferase 6.8
EC 4.4.1.5 6.7
lysine acetyltransferase 6.4
factor C 6.4
histone acetyltransferase 6.0
SLB 5.7
Rex 5.7
jararhagin 5.6
TGT 5.5
PHD 5.5
Lys4 5.5
DNA methyltransferase 5.5
thiopurine methyltransferase 5.4
focal adhesion kinase 5.2
Protein 2 5.2
sphingomyelin synthase 5.1
caspase-6 5.0
caspase-6 5.0
p80 4.8
CD13 4.8
topoisomerase 4.7
p100 4.7
topoisomerase 4.6
Fpg protein 4.5
isocitrate dehydrogenase 4.5
FPS 4.5
oxidosqualene cyclase 4.5
sphingosine kinase 4.4
CEP 4.4
protein phosphatase 2A 4.4
isocitrate dehydrogenase 4.4
ERK 4.3
xylose isomerase 4.3
dUTPase 4.3
CGT 4.1
demethylase 4.1
TdT 4.1
histone demethylase 4.1
alpha-L-fucosidase 4.0
phosphatidylinositol 3-kinase 4.0
N-acetylglucosaminyltransferase 4.0
farnesyltransferase 3.9
alpha-L-fucosidase 3.9
CD10 3.8
CEP 3.8
cdc2 3.8
Thy1 3.7
reverse transcriptase 3.7
prenyltransferase 3.7
phosphoinositide 3-kinase 3.6
polynucleotide kinase 3.5
MEK 3.5
asparaginase 3.5
methionine adenosyltransferase 3.5
IKK 3.5
deoxycytidine kinase 3.5
transcriptase 3.4
alpha-L-fucosidase 3.4
PDK1 3.4
farnesyltransferase 3.4
FAST 3.4
AGT 3.3
matrix metalloproteinase 2 3.3
MCS 3.3
glutamate synthase 3.3
neutrophil elastase 3.3
CDR 3.2
BAT 3.2
hypoxanthine-guanine phosphoribosyltransferase 3.2
cathepsin G 3.1
Pla 3.1
IMP dehydrogenase 3.1
GAS 3.0
PTPase 3.0
mitogen-activated protein kinase 2.9
proprotein convertase 2.8
matrix metalloproteinase 9 2.8
GSK 2.8
calcineurin 2.8
proteasome 2.8
luciferase 2.8
TAT 2.7
TSA 2.7
RNA polymerase 2.7
chloramphenicol acetyltransferase 2.6
BMT 2.6
TOR 2.4
MAP 2.4
triphosphatase 2.4
polo-like kinase 1 2.4
NQO1 2.3
MIP 2.3
protein kinase 2.2
PARP 2.2
phosphoglucose isomerase 2.2
gamma-glutamyl transpeptidase 2.1
MEKK1 2.1
caspase-9 2.1
glutathione S-transferase 2.1
methylenetetrahydrofolate reductase 1.9
methylenetetrahydrofolate reductase 1.9
aldehyde dehydrogenase 1.8
aldehyde dehydrogenase 1.8
soluble epoxide hydrolase 1.8
aldehyde dehydrogenase 1.8
CPT 1.8
caspase-3 1.7
thymidine kinase 1.6
adenosine deaminase 1.6
aldehyde dehydrogenase 1.6
adenosine deaminase 1.6
peroxiredoxin 1.6
DNA ligase 1.5
DNA ligase 1.5
dihydrofolate reductase 1.4
5'-nucleotidase 1.3
CPT 1.3
STR 1.3
furin 1.3
aldehyde dehydrogenase 1.3
peroxidase 1.3
granzyme B 1.2
CPT 1.2
lysozyme 1.1
S1 nuclease 1.1
endonuclease 1.1
phospholipase D 1.1
glucose-6-phosphate dehydrogenase 1.0
acid phosphatase 0.9
MDR 0.8
P-glycoprotein 0.8
elastase 0.8
ceruloplasmin 0.6
NADPH oxidase 0.6
APC 0.5
RNase 0.5
NADPH oxidase 0.5
DNA polymerase 0.5
RNase 0.4
phospholipase C 0.3
protein kinase C 0.3
caspase-1 0.3
CYP3A4 0.3
adenylate cyclase 0.3
glyceraldehyde-3-phosphate dehydrogenase 0.3
ribonuclease 0.2
ribonuclease 0.2
caspase-8 0.2
lactate dehydrogenase 0.1
beta-galactosidase 0.1
catalase -0.0
alkaline phosphatase -0.0
guanylate cyclase -0.1
complex I -0.2
collagenase -0.2
ATPase -0.5
cholinesterase -0.7
AMP-activated protein kinase -0.7
neuraminidase -0.9
ACE -1.2
more...
Compound
TEL 9.4
N-butylurea 8.7
KTS 7.8
Bisdemethoxycurcumin 7.8
KT-1 7.5
TKB 7.5
Benzene 7.3
ABL 7.2
BCR 7.2
Pyran 7.1
ara-AMP 7.0
ara-AMP 7.0
DEK 6.9
Rifamycin 6.8
1,2,4-benzenetriol 6.8
TLL 6.7
MHT 6.7
Deguelin 6.6
Rifamycin 6.6
Rifamycin 6.5
Homoharringtonine 6.4
SC-1 6.4
SC-1 6.3
hydroxyglutarate 6.3
1,3-Butadiene 6.2
E-4031 6.1
5-Aza-2'-deoxycytidine 6.0
HMBA 6.0
CAN 6.0
TET 5.9
TET 5.9
SET 5.9
Rifamycin 5.9
CD 3 5.8
TGT 5.8
DCL 5.6
HMBA 5.6
DOA 5.6
NFS 5.5
DAM 5.5
HPC 5.5
HPC 5.5
retinoic acid 5.3
Ara-C 5.3
DAM 5.2
Oridonin 5.2
GBL 5.2
MNU 5.2
HCP 5.1
Deoxycoformycin 5.1
MAL 5.1
Ara-C 5.1
GBL 5.0
isocitrate 5.0
Geldanamycin 4.9
Ethylene oxide 4.9
Novobiocin 4.9
Nicotinic acid adenine dinucleotide phosphate 4.9
MNU 4.9
HCP 4.9
hydroquinone 4.7
Sulindac 4.6
CAA 4.5
Valproic acid 4.5
ETH 4.5
Ribose 4.5
Cbl 4.4
NOXA 4.4
Hydroxyurea 4.4
ENU 4.3
Glycogen synthase 4.3
NOP 4.3
CHIP 4.2
IDU 4.2
5-Azacytidine 4.2
phosphonoacetic acid 4.2
Lawson 4.2
Histone 4.1
DFS 4.1
Selectin 4.1
5-formyltetrahydrofolate 4.1
VP-16 4.1
Porphyrin 4.0
Porphyrin 4.0
PAC 4.0
Busulfan 3.9
AME 3.9
DEC 3.9
Nicotinic acid adenine dinucleotide phosphate 3.9
HOG 3.9
AF-2 3.8
DAC 3.8
DBA 3.8
CMK 3.8
ECS 3.7
DBD 3.7
DBA 3.7
Arsenite 3.7
benzene 3.7
DBA 3.7
Ribavirin 3.7
Mitoxantrone 3.7
STP 3.6
TDI 3.6
Mitoxantrone 3.6
APO 3.6
TPA 3.5
PNU 3.5
Quinone 3.5
MEK 3.4
DEP 3.4
tyrosine 3.4
Menadione 3.3
L-PAM 3.3
L-PAM 3.3
TPA 3.3
anthracene 3.3
CDP 3.3
AAT 3.2
T11 3.1
1,3-propanediol 3.1
TCC 3.1
DRB 3.0
Coumarin 3.0
PCI 3.0
DPI 3.0
DEP 3.0
NPP 3.0
THP 2.9
PID 2.9
GAP 2.9
PID 2.9
THP 2.9
Emodin 2.9
Valproic acid 2.8
Calcitonin 2.8
Lewis X 2.7
lysine 2.7
PNA 2.7
DNA 2.7
2-oxoglutarate 2.7
Bisulfite 2.7
GGG 2.6
2,3-diphosphoglycerate 2.6
Ubiquitin 2.6
PPA 2.5
Argentine 2.5
NBT 2.5
LIN 2.4
Interleukin-2 2.4
A 42 2.4
BUdR 2.4
CAT 2.4
CAT 2.4
MCA 2.3
CAT 2.3
threonine 2.2
Serine 2.2
GM2 2.2
LSD 2.2
more...