Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0596263 (carcinogenesis)
 64,820 document(s) hit in 31,850,051 MEDLINE articles (0.04 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
p53 4750
Sep 4288
Mol 3813
ras 1027
histone 960
cyclin D1 897
p21 892
cyclooxygenase-2 859
catenin 840
cytokine 817
glutathione S-transferase 768
estrogen receptor 741
E-cadherin 720
insulin 698
beta-catenin 686
proliferating cell nuclear antigen 683
COX-2 667
p16 664
AKT 651
epidermal growth factor receptor 651
microsomal 631
Bcl-2 611
caspase-3 590
cytochrome P450 585
catalase 562
ornithine decarboxylase 550
PI3K 538
GSH 529
K-ras 519
mTOR 515
vascular endothelial growth factor 496
superoxide dismutase 492
APC 490
MAPK 489
c-myc 485
tumour suppressor 478
gut 472
Ki-67 446
thymus 443
tumor necrosis factor 431
GST 428
cage 427
cyclooxygenase 424
ERK 417
PTEN 394
p38 392
EGFR 384
xenobiotic 383
epidermal growth factor 378
inducible nitric oxide synthase 374
KRAS 373
CYP1A1 370
TNF 369
IL-6 362
tyrosine kinase 356
androgen receptor 351
BRCA1 342
ERK1 339
collagen 337
lymphoid 333
glutathione peroxidase 333
c-Myc 332
TNM 330
STAT3 328
p27 327
UTR 326
proto-oncogene 326
cytochrome 314
ubiquitin 304
AP-1 302
BRAF 302
mucin 299
H-ras 297
ATP 293
P450 291
HER2 290
TPA 289
matrix metalloproteinase 288
TGF-beta 283
c-Jun 282
adenomatous polyposis coli 279
VEGF 271
proteasome 270
NADPH 261
extracellular signal-regulated kinase 259
p65 258
colon carcinoma 258
cytochrome P-450 257
hairless 253
DNA methyltransferase 249
progesterone receptor 248
endoplasmic reticulum 245
histone deacetylase 241
cyclin 238
Nrf2 234
methylguanine-DNA methyltransferase 231
MMP-9 230
interferon 228
insulin-like growth factor 225
JNK 218
CD44 217
cancer susceptibility 215
bcl-2 214
INK4a 213
telomeric 212
MEK 211
vimentin 211
ROS 211
c-fos 210
p16INK4a 209
erbB-2 209
IL-8 202
aryl hydrocarbon receptor 201
cyclin E 201
BRCA2 199
EGF 198
mutant p53 197
PARP 195
leptin 194
histone H3 192
reductase 190
polypeptide 190
NMR 190
Cyclin D1 190
osteosarcoma 189
neu 189
survivin 188
GSTM1 186
lipopolysaccharide 185
peroxidase 183
pRb 183
CD8 182
phosphatidylinositol 3-kinase 181
phosphatase 181
glycoprotein 180
Pol 178
chemokine 172
albumin 172
keratin 171
CYP1A2 171
telomerase reverse transcriptase 170
CYP1B1 169
gamma-glutamyltranspeptidase 168
nitric oxide synthase 168
MMP-2 167
GSTP1 167
DNMT1 167
cytochrome c 166
interleukin-6 166
hMLH1 166
nuclear receptor 164
BOP 164
NAD 164
MYC 161
gastrin 161
c-Ha-ras 161
hemoglobin 159
methyltransferase 158
hepatocyte growth factor 158
AGS 156
more...
Disease
carcinogenesis 64820
cancer 30464
tumor 21494
carcinoma 5623
tumorigenesis 4964
breast cancer 4139
colorectal cancer 3501
tumor progression 2891
hepatocellular carcinoma 2821
lung cancer 2705
adenocarcinoma 2699
squamous cell carcinoma 2480
gastric cancer 2401
colon cancer 2325
tumor growth 1918
prostate cancer 1908
dysplasia 1514
adenoma 1266
metastases 1246
cervical cancer 1220
skin cancer 1049
pancreatic cancer 888
bladder cancer 842
melanoma 833
liver cancer 801
ovarian cancer 749
obesity 659
leukemia 657
neoplastic transformation 652
liver cancer 647
MCF 608
papilloma 607
endometrial cancer 559
hepatitis B 537
non-small cell lung cancer 532
GSH 529
oral cancer 517
chemical carcinogenesis 503
cirrhosis 496
APC 493
skin tumor 488
Epstein 483
renal cell carcinoma 471
lymphoma 464
diabetes 460
esophageal cancer 459
colitis 439
gastritis 428
mammary tumor 423
esophageal cancer 417
tumor initiation 413
retinoblastoma 396
lung carcinoma 393
Hepatocellular carcinoma 381
aggressiveness 361
epithelial ovarian cancer 345
carcinoma in situ 319
primary tumor 313
cervical intraepithelial neoplasia 303
glioma 302
Helicobacter pylori infection 301
familial adenomatous polyposis 301
thyroid cancer 295
Barrett's esophagus 293
xeroderma pigmentosum 271
inflammatory bowel disease 270
ulcerative colitis 263
hepatitis C 258
AIN 256
virus infection 252
atrophic gastritis 248
head and neck cancer 235
sarcoma 234
invasive cancer 230
ATM 225
uterine cervix 218
infectious diseases 213
osteosarcoma 212
basal cell carcinoma 210
uterus 209
chronic hepatitis 206
tumor angiogenesis 203
Infection 189
hepatitis 187
mesothelioma 182
polyposis 177
liver disease 177
glioblastoma 172
Colon 170
Colon 170
human papilloma virus 170
human papilloma virus 170
Colon 170
atherosclerosis 164
PIN 161
AGS 156
acute myeloid leukemia 154
renal disease 154
renal cancer 142
cardiovascular disease 136
ductal carcinoma in situ 135
Hippel 130
HCC 129
rectal cancer 128
Hodgkin's disease 127
B-cell lymphoma 125
Colon cancer 119
gastrointestinal cancer 118
anemia 117
gastroesophageal reflux disease 117
neuroblastoma 114
depression 111
hypertension 110
multiple myeloma 110
type 2 diabetes 110
transitional cell carcinoma 108
leukoplakia 107
DBA 107
metabolic syndrome 107
HIV 107
Esophageal 106
SCID 106
papillary thyroid cancer 106
Lynch syndrome 105
EMT 104
ductal carcinoma 103
neoplastic process 102
liver fibrosis 99
ARF 99
WT1 99
Crohn's disease 99
keratosis 97
hyperinsulinemia 97
hyperkeratosis 95
small cell lung cancer 94
fatty liver 93
SDS 92
aggression 92
Esophageal squamous cell carcinoma 90
immunodeficiency 90
fallopian tube 90
EBV infection 89
gallbladder cancer 89
peptic ulcer 88
cold 85
oral leukoplakia 85
acute promyelocytic leukemia 84
chronic pancreatitis 84
Nasopharyngeal carcinoma 84
endometrial hyperplasia 83
viral hepatitis 82
XPD 81
malignant mesothelioma 81
Dukes 81
PSA 80
Carcinogenicity 80
solid tumor 80
endometriosis 79
laryngeal cancer 79
DSS 79
more...
Symptom
erythema 88
pain 75
starvation 75
overweight 59
diarrhea 59
hepatomegaly 49
skin damage 46
anesthesia 26
abdominal pain 26
acidity 26
cachexia 23
weakness 21
exhaustion 20
seizures 17
fatigue 16
collapse 16
hyperoxia 15
skin irritant 15
lethargy 14
splenomegaly 14
nausea 13
anorexia 12
ataxia 11
thinning 11
dyspnea 11
constipation 11
vomiting 11
skin irritation 10
cough 10
headache 10
flushing 9
regurgitation 8
menopausal symptoms 8
ENT 8
analgesia 8
discomfort 7
respiratory distress 7
discomfort 7
tremor 7
Ill 7
colic 6
hypothermia 5
Fluctuation 5
cancer pain 5
microbial colonization 5
chest pain 5
back pain 4
prostration 4
Spots 4
dizziness 4
epigastric pain 4
myalgia 3
arthralgia 3
DNA marker 3
rhinorrhea 3
intestinal bleeding 3
peri-menopausal 3
HSA 3
hunger 3
dry skin 3
Wind 3
bloating 3
angina 3
nausea and vomiting 3
hot flashes 2
paresis 2
hypoproteinemia 2
breast hyperplasia 2
chronic constipation 2
mastalgia 2
productive cough 2
nasal discharge 2
nipple discharge 2
clubbing 2
loss of balance 2
cyanosis 2
hoarseness 2
nipple discharge 2
sleepiness 2
insomnia 2
acute stress 2
bitter taste 2
emaciation 2
bone pain 2
scaly skin 2
polydipsia 2
vertigo 2
masculinization 2
disturbed balance 2
halitosis 2
heartburn 2
stigma 2
pallor 2
numbness 2
wheezing 2
autodigestion 1
hepatosplenomegaly 1
Mucosal hyperplasia 1
chills 1
spasm 1
leg edema 1
cerebellar ataxia 1
hot flushes 1
general problem 1
neck pain 1
Soft stools 1
Stinging 1
leg cramps 1
irregular bleeding 1
abdominal discomfort 1
exertional dyspnea 1
apathy 1
low back pain 1
CSR 1
stomach pain 1
neuralgia 1
Gastrointestinal symptoms 1
renal colic 1
physical appearance 1
muscle cramps 1
No adverse effect 1
High weight 1
labored breathing 1
polyuria 1
syncope 1
Decreased activity 1
knee pain 1
breakthrough pain 1
eds 1
tachypnea 1
abnormal breathing 1
despair 1
renal pain 1
dysuria 1
sore throat 1
hopelessness 1
prostatism 1
distraction 1
enuresis 1
upset stomach 1
left upper quadrant pain 1
abnormal gait 1
No toxic effect 1
memory loss 1
agitation 1
pelvic pain 1
incoordination 1
flank pain 1
tenesmus 1
inflammation of the vulva 1
Hudson 1
blepharospasm 1
Scratch 1
acute pain 1
Climacteric symptoms 1
Breast tenderness 1
excessive urination 1
acute abdomen 1
hemoptysis 1
muscular incoordination 1
more...
Drug
Dermatol 484
ascorbate 366
lysine 315
vitamin E 267
Mutagen 253
ROS 211
caffeine 148
NADH 111
Glutathione 109
MAP 92
Estrogens 79
EE2 65
IFN-gamma 62
Retinoic acid 60
ICI 55
Vitamin A 50
Paraffin 50
Ethanol 49
GEO 48
PTC 48
IL-2 47
-deoxyadenosine 45
Monit 44
Vitamin E 44
EPA 42
Asn 41
Gel 41
Arsenic trioxide 41
Bifidobacterium 41
ETS 41
ABC 39
Indomethacin 38
G418 35
MRC 33
CTA 33
Leaf 28
ROC 28
DNase I 27
niacin 26
Heme 25
CAM 25
Sorafenib 24
PCB 24
Cardiovasc 24
uPA 22
CSF 21
BLM 19
Nitric Oxide 19
THF 19
Gefitinib 18
Herceptin 18
ENT 17
Taxol 17
Areca 17
Tocopherol 16
Fraction 16
Imatinib 16
lactose 16
Activin 16
CTX 16
Cetuximab 14
Dihydro 14
Aloe 13
Albumin 13
AGG 13
Furan 13
Adriamycin 12
VCR 12
TiO2 11
R1881 11
Epigallocatechin 11
FAD 11
G-CSF 11
Bevacizumab 11
IL-1ra 10
Ciprofibrate 10
linolenate 10
Myricetin 10
Nimesulide 10
Angiotensin II 10
Gleevec 10
HCH 10
ALA 9
CaCl2 9
Ginger 9
NH3 9
ampicillin 9
Raloxifene 9
Erlotinib 9
RAL 9
Rosiglitazone 9
Tannic acid 9
Serum albumin 9
BH4 9
Biopolymers 8
Histamine 8
Vorinostat 8
IFN-beta 8
Glycyrrhiza 8
Growth hormone 8
Vitamin K 8
NBT 8
DHT 8
CCL 8
ADM 8
ADR 8
Ginseng 8
CaCl2 8
CrCl3 8
CaCl2 8
Growth hormone 8
Bexarotene 8
Silica 8
p75 8
DHT 8
Omeprazole 8
AZT 7
citric acid 7
Coal tar 7
NOV 7
Corn oil 7
Limonene 7
Fluorescein 7
pyridoxal phosphate 7
Docetaxel 7
Lugol 7
Pronase 7
L-tyrosine 7
DEL 7
Doxycycline 7
Etoposide 7
CTC 7
AZT 7
Gelatin 7
Honey 7
Bortezomib 6
Lovastatin 6
Rebamipide 6
Clofibrate 6
Triad 6
CDX 6
balanced salt solution 6
Triad 6
Riboflavin 6
Amiloride 6
Rutin 6
Olive oil 6
Forskolin 6
Vitamin B 6
HCG 6
all-trans-retinol 6
Norplant 6
CPT-11 6
Itraconazole 6
3-Methyladenine 6
NVP 6
Premarin 6
Swertia 6
TAC 6
Fructose 6
more...
Enzyme
ERK 1584
mitogen-activated protein kinase 1484
glutathione S-transferase 1040
luciferase 751
protein kinase 645
catalase 637
superoxide dismutase 563
ornithine decarboxylase 550
protein kinase C 509
APC 495
gamma-glutamyl transpeptidase 461
caspase-3 432
focal adhesion kinase 417
glutathione peroxidase 347
MEK 318
peroxidase 307
NQO1 295
reverse transcriptase 280
proteasome 271
DNA methyltransferase 260
PARP 244
DNA polymerase 212
ATPase 196
phosphatidylinositol 3-kinase 181
cdc2 181
alkaline phosphatase 142
endonuclease 141
glutathione reductase 133
RNA polymerase 132
lipoxygenase 128
GSK 126
alanine aminotransferase 119
aldehyde dehydrogenase 115
AMP-activated protein kinase 113
demethylase 113
aldehyde dehydrogenase 112
collagenase 109
soluble epoxide hydrolase 109
caspase-9 108
prostate-specific antigen 108
aldehyde dehydrogenase 105
aldehyde dehydrogenase 105
aldehyde dehydrogenase 105
lactate dehydrogenase 95
topoisomerase 94
beta-glucuronidase 94
UDP-glucuronosyltransferase 92
caspase-8 92
glucose-6-phosphate dehydrogenase 92
urokinase-type plasminogen activator 92
hypoxanthine-guanine phosphoribosyltransferase 91
aspartate aminotransferase 84
N-acetyltransferase 84
aryl hydrocarbon hydroxylase 84
phosphoinositide 3-kinase 83
MMP 81
trypsin 81
topoisomerase 80
IKK 78
alcohol dehydrogenase 77
NO synthase 76
microsomal epoxide hydrolase 75
xanthine oxidase 74
NADPH oxidase 73
AMPK 71
NADPH oxidase 70
phospholipase A2 69
glucose-6-phosphatase 68
calcineurin 66
P-glycoprotein 65
thymidine kinase 65
RNase 65
PAH 65
RNase 65
DNA ligase 60
DNA ligase 60
AMPK 58
CYP3A4 57
methylenetetrahydrofolate reductase 56
methylenetetrahydrofolate reductase 56
MAP 54
phospholipase C 49
beta-galactosidase 48
transcriptase 47
succinate dehydrogenase 45
prostaglandin synthetase 44
pyruvate kinase 42
transglutaminase 39
CPR 39
PDE 39
glyceraldehyde-3-phosphate dehydrogenase 39
dihydrofolate reductase 38
matrix metalloproteinase 2 37
MMP-3 37
sulfatase 36
heme oxygenase 36
CD10 36
thymidylate synthase 35
AST 35
histone acetyltransferase 35
DNase 34
matrix metalloproteinase 9 34
renin 34
polynucleotide kinase 33
Fpg protein 33
glyceraldehyde-3-phosphate dehydrogenase 33
NOS 32
15-hydroxyprostaglandin dehydrogenase 32
phosphodiesterase 32
diaphorase 32
urease 31
isocitrate dehydrogenase 31
urease 31
cathepsin D 31
isocitrate dehydrogenase 29
ACE 29
chloramphenicol acetyltransferase 29
micrococcal nuclease 28
histone demethylase 28
acid phosphatase 27
peroxiredoxin 27
caspase-1 27
chymotrypsin 26
glyceraldehyde-3-phosphate dehydrogenase 26
glyceraldehyde-3-phosphate dehydrogenase 26
glutamine synthetase 26
glyceraldehyde-3-phosphate dehydrogenase 26
AGT 25
PDK1 25
gamma-glutamylcysteine synthetase 25
complex I 25
neuraminidase 25
tyrosinase 25
carbonic anhydrase 25
methionine synthase 24
adenylate cyclase 24
methionine synthase 23
monoamine oxidase 23
thioredoxin reductase 23
caspase-7 22
polo-like kinase 1 22
triphosphatase 22
STK11 22
estrogen sulfotransferase 22
caspase-7 22
acyl-CoA oxidase 22
kallikrein 22
histidine kinase 21
transpeptidase 21
CGT 21
phosphorylase 21
TGT 21
GAS 21
cathepsin B 21
15-lipoxygenase 21
S-adenosylmethionine decarboxylase 21
ATP synthase 20
aldose reductase 20
ALDH 20
ACS 20
more...
Compound
DNA 15332
Dec 4543
oxygen 2393
water 2113
acetate 1969
Clin 1922
anthracene 1789
pyrene 1582
sodium 1216
DBA 802
calcium 769
GSH 621
GSH 621
sulfate 585
iron 575
1,2-dimethylhydrazine 560
hydrogen 553
tyrosine 532
glucose 504
retinoic acid 502
ethanol 483
nitric oxide 481
selenium 464
phosphate 462
cysteine 450
aflatoxin B1 437
methionine 433
lysine 398
MDA 371
TNF 369
nitrogen 360
pyridine 353
H2O2 349
TNM 331
arginine 330
serine 329
zinc 324
8-OHdG 308
MTT 300
TPA 296
ATP 294
TPA 289
nickel 285
copper 275
aldehyde 267
Pac 265
chromium 261
NADPH 261
NADPH 261
pyrimidine 258
pyrimidine 257
vitamin D 249
acetone 247
threonine 241
DEN 232
Estrogen 232
cadmium 228
salt 225
quinoline 223
quinoline 222
Estrogen 221
PGE 211
NAD 211
MEK 211
Curcumin 205
urea 205
AAF 205
His 197
benzene 194
Arsenic 192
retinol 184
PGE2 175
N-acetylcysteine 174
formaldehyde 167
ADP 166
NAD 164
BOP 164
acetaldehyde 161
alanine 156
nitrate 152
leucine 151
aldehyde 150
caffeine 148
ADP 147
ADP 147
Resveratrol 145
SCC 145
iodine 143
bromide 136
ADP-ribose 132
phenol 131
indole-3-carbinol 131
MNU 128
ASA 128
cAMP 125
adenosylmethionine 121
formaldehyde 121
potassium 117
COX 117
DBA 115
tryptophan 114
vinyl 114
Insulin 114
proline 113
NADH 111
nicotinamide 110
PGA 110
NH2 110
DBA 107
MNU 107
silver 105
DMSO 104
hydroquinone 103
CO2 99
UDP 97
tryptophan 97
GTP 96
methanol 96
galactose 94
tryptophan 94
Tamoxifen 94
tryptophan 94
SDS 91
ACI 91
Tamoxifen 91
Carcinogen 91
Asp 90
Benzo[a]pyrene 89
chromate 89
Thyroid 89
dUTP 88
Ile 87
creatinine 87
PhIP 86
DCC 85
butyric acid 83
Cu(II) 82
DSS 81
Ascorbic acid 81
CAT 81
CAT 80
CAT 80
MNNG 79
TOF 78
chloroform 78
1-butanol 78
AMP 77
valine 75
hydrazine 75
glutamine 74
NTA 74
chrysene 74
hydroxide 74
EDTA 73
CCl4 72
uridine 72
homocysteine 72
MCA 71
Phe 70
2-ethylhexyl 70
more...