Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Query: UMLS:C0596263 (
carcinogenesis
)
64,820
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We previously reported an important role of
RQCD1
in mammary
carcinogenesis
through the interaction with Grb10 interacting GYF protein 1 (GIGYF1), Grb10 interacting GYF protein 2 (GIGYF2) and growth factor receptor binding protein 10 (Grb10). In this study, we investigated the biological mechanism of
RQCD1
in regulation of the Akt activity as the downstream signal of epidermal growth factor receptor (EGFR). Knockdown of
RQCD1
reduced the Akt phosphorylation level that was induced by epidermal growth factor (EGF) stimulation. We found a possible formation of the big complex involved in the Akt activity including Akt, EGFR, GIGYF1 and GIGYF2, Grb10 and
RQCD1
. We subsequently defined that a region corresponding to 620-665th amino acids of GIGYF1 and 667-712th amino acids of GIGYF2 interacted with
RQCD1
. Furthermore, we found that
RQCD1
was required for enhancement of the interaction of Grb10 with GIGYF1 and GIGYF2. Our findings in this study imply the functional mechanism of
RQCD1
in the Akt activity regulation as a mediator in the EGFR-signaling pathway.
...
PMID:Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis. 2087 56
