Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0596263 (
carcinogenesis
)
64,820
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Adenosylmethionine decarboxylase 1
(
AMD1
) is a key enzyme involved in biosynthesis of polyamines including spermidine and spermine. The potential function of
AMD1
in human gastric cancers is unknown. We analyzed
AMD1
expression level in 319 human gastric cancer samples together with the adjacent normal tissues. The protein expression level of
AMD1
was significantly increased in human gastric cancer samples compared with their corresponding para-cancerous histological normal tissues (P < 0.0001). The expression level of
AMD1
was positively associated with Helicobactor pylori 16sRNA (P < 0.0001), tumor size (P < 0.0001), tumor differentiation (P < 0.05), tumor venous invasion (P < 0.0001), tumor lymphatic invasion (P < 0.0001), blood vessel invasion (P < 0.0001), and tumor lymph node metastasis (TNM) stage (P < 0.0001). Patients with high expression of
AMD1
had a much shorter overall survival than those with normal/low expression of
AMD1
. Knockdown of
AMD1
in human gastric cancer cells suppressed cell proliferation, colony formation and cell migration. In a tumor xenograft model, knockdown of
AMD1
suppressed the tumor growth in vivo. Inhibition of
AMD1
by an inhibitor SAM486A in human gastric cancer cells arrested cell cycle progression during G1-to-S transition. Collectively, our studies at the cellular, animal and human levels indicate that
AMD1
has a tumorigenic effect on human gastric cancers and affect the prognosis of the patients.
Carcinogenesis
2020 04 22
PMID:Polyamine synthesis enzyme AMD1 is closely associated with tumorigenesis and prognosis of human gastric cancers. 3114 May 54
