Gene/Protein
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Drug
Enzyme
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Pivot Concepts:
Gene/Protein
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Target Concepts:
Gene/Protein
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Query: UMLS:C0596263 (
carcinogenesis
)
64,820
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Long non-coding RNAs (lncRNAs) have been reported to play important roles in glioma; however, most of them promote glioma progression. We constructed a competing endogenous (ceRNA) network based on the Chinese Glioma Genome Atlas dataset, and lncRNA hect domain and RLD 2 pseudogene 2 (
HERC2P2
) is the core of this network. Highly connected genes in the ceRNA network classified the glioma patients into three clusters with significantly different survival rates. The expression of
HERC2P2
is positively correlated with survival and negatively correlated with clinical grade. Cell colony formation, Transwell and cell scratch tests were performed to evaluate the role of
HERC2P2
in glioblastoma growth. Furthermore, we overexpressed
HERC2P2
in U87 cells and established a mouse intracranial glioma model to examine the function of
HERC2P2
in vivo. In conclusion, we identified a lncRNA with tumor suppressor functions in glioma that could be a potential biomarker for glioma patients.
Carcinogenesis
2019 08 22
PMID:Identification of long non-coding RNA HERC2P2 as a tumor suppressor in glioma. 3080 32
