Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0596263 (carcinogenesis)
 64,820 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Localization of characteristic precancerous lesions was compared with that of alpha-fetoprotein (alpha-FP) positive cells during hepatocarcinogenesis in Wistar rats fed 0.06% 3'-methyl-4-dimethylaminoazobenzene in basal diet. Proliferative activity of liver cells was simultaneously followed by deoxycytidylate deaminase. The first alpha-FP positive hepatocytes were found after 3 weeks of carcinogenesis in certain parts of the capsule 0.1--0.2 mm thick. In the seventh week of carcinogenesis their number increased and they were present in groups also subcapsularly. At this stage, hyperplastic islets began to be formed in the liver parenchyma. After 14 weeks of carcinogenesis, alpha-FP positive cell clusters and islets were also found in the deeper layers of liver parenchyma in regions with proliferation of transitory cells. Hyperplastic basophilic foci and islets occurred regularly, however, these were not identical with alpha-FP positive sites and their incidence was more frequent.
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PMID:Relationship between alpha-fetoprotein positive cells and precancerous lesions in rat liver during 3'-methyl-4-dimethylaminoazobenzene carcinogenesis. 9 42

Determination of activity of deoxycytidylate deaminase stabilized by etylene glycol was used to evaluate the rate of DNA synthesis in precancerous liver tissue and in transplantable rat hepatomas. Increased activity of the enzyme in macroscopically unchanged liver tissue occurred during hepatocarcinogenesis induced by 3'-Me-DAB in the period between weeks 1 and 10. The slow growing transplantable tumours derived from primary hepatomas induced by DAB and AF showed slightly increased activity, while the fast growing lines derived from primary tumours induced by 3'-Me-DAB were characterized by markedly increased activity. Thus the enzyme appeared to be a good marker of tumour growth rate. Correlation between increased DNA synthesis during carcinogenesis and the occurrence of alpha-fetoprotein is briefly discussed.
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PMID:Correlation of deoxycytidylate deaminase activity with cell proliferation during hepatocarcinogenesis and tumour growth in transplantable rat hepatomas. 677 98