Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0596263 (
carcinogenesis
)
64,820
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Calpains are a family of intracellular cysteine proteases involved in various biological processes. Previously, the family was identified to have abnormal expression in several types of malignant tumor. Calpain 6 was less well known; however, it was recently identified to be involved in the
carcinogenesis
of certain types of malignant tumor. However, the expression of
calpain 6
in head and neck squamous cell carcinoma (HNSCC) remains unclear. A total of six datasets from the Gene Expression Omnibus (GEO) was analyzed and an association between
calpain 6
expression levels and HNSCC was identified, with the expression of
calpain 6
observed to be significantly decreased in HNSCC (P<0.01). However, the expression of
calpain 6
may vary between distinct tumor stages of HNSCC. Furthermore,
calpain 6
expression was positively associated with the survival rate in patients with HNSCC (P<0.05), with increased expression of
calpain 6
associated with an improved survival outcome. Calpain 6 expression was analyzed using an HNSCC tissue microarray and these results were consistent with the statistical analysis of the bioinformatics data from the GEO, indicating that
calpain 6
may be a tumor suppressor protein in HNSCC.
...
PMID:Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC. 2845 86
