Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0596263 (
carcinogenesis
)
64,820
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Our previous studies revealed that
cytokine induced apoptosis inhibitor 1
(
CIAPIN1
), which was reported to be essential in mouse definitive hematopoiesis, was related to multidrug resistance in gastric cancer cells and that the distribution of
CIAPIN1
in normal human tissues was similar to the distribution of Ras. This study aimed to explore whether
CIAPIN1
plays a role in gastric
carcinogenesis
. Expression of
CIAPIN1
in normal, inflammatory gastric mucosa, gastric precancerous lesions and gastric adenocarcinoma was detected by immunohistochemistry and western blotting and, influence of
CIAPIN1
on the proliferation of gastric cancer cells was investigated by ectopic expression of
CIAPIN1
and RNA interference (RNAi). Our immunohistochemical results demonstrated that the expression of
CIAPIN1
in gastric antral mucosa was progressively reduced along the sequence of normal/inflammatory gastric mucosa-atrophy-intestinal metaplasia-dysplasia-adenocarcinoma. The downregulation of
CIAPIN1
in cancerous tissues was further confirmed by western blotting. No relationship between the expression level of
CIAPIN1
and the clinicopathological parameters such as age, gender, differentiation, TNM stage and the existence of metastasis was found in gastric cancer patients. In in vitro cellular experiments, ectopic expression of
CIAPIN1
by cDNA transfection resulted in suppression of cell proliferation and inhibition of cell cycle progression while knockdown of
CIAPIN1
with siRNA accelerated cell proliferation and promoted cell cycle progression in SGC7901 and MKN28 gastric cancer cells. These results suggest that downregulated
CIAPIN1
expression may contribute to gastric
carcinogenesis
by accelerating cell proliferation and promoting cell cycle progression.
...
PMID:Downregulated expression of CIAPIN1 may contribute to gastric carcinogenesis by accelerating cell proliferation and promoting cell cycle progression. 1947 Nov 13
