Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0596263 (carcinogenesis)
 64,820 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Placental choriocarcinoma, a reproductive system carcinoma in women, has about 0.81% occurrence frequency in China, which leads to over 90% lethality due to indistinct pathogenesis and the absence of efficient therapeutic treatment. In the present study, using immunostaining and reverse transcription PCR, we reported that Dickkopf-1 (Dkk-1) is prominently expressed in human cytotrophoblast (CTB) cell, but absent in the human placental choriocarcinoma cell line JAR and JEG3, implicating an unknown correlation between Dkk-1 and carcinogenesis of placental choriocarcinoma. Further, through exogenous introduction of Dkk-1, we found repressed proliferation in JAR and JEG3, induced apoptosis in JAR, and discovered significant tumor suppression effects of Dkk-1 in placental choriocarcinoma. Moreover we found that this function of Dkk-1 is achieved through c-Jun N-terminal kinase (JNK), whereas the canonical Wnt pathway may not have a great role. This discovery is not symphonic to previous functional understanding of Dkk-1, a canonical Wnt signaling antagonist. Together, our data indicate the possible correlation between Dkk-1 and human placental choriocarcinoma and suggest potential applications of Dkk-1 in treatment of human placental choriocarcinomas.
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PMID:Dickkopf-1 induced apoptosis in human placental choriocarcinoma is independent of canonical Wnt signaling. 1702 60

Placental choriocarcinoma is a highly malignant tumor of the female reproductive organs. Even with chemotherapy, placental choriocarcinoma has a 20% mortality rate due to its indistinct pathogenesis and the absence of efficient therapeutic methods for this cancer. Wnt proteins and Wnt signaling are involved in a variety of developmental and cellular processes, and aberrant activation of Wnt signaling is linked to carcinogenesis in many types of tissue. In the present study, using immunostaining and reverse transcription PCR, we found that Wnt5a was prominently expressed in human primary cytotrophoblast cells, but absent in the human choriocarcinoma cell line JAR. This implies that there is a previously unknown correlation between Wnt5a and placental choriocarcinoma. Furthermore, we found that the addition of exogenous recombinant Wnt5a protein to the JAR cells repressed their proliferation and induced apoptosis, indicating that Wnt5a has a tumor suppressive effect in placental choriocarcinoma. In conclusion, the results of the present study suggest that there is a correlation between Wnt5a and human placental choriocarcinoma; therefore, Wnt5a has a potential use in the treatment of this malignancy.
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PMID:Effects of Wnt5a protein on proliferation and apoptosis in JAR choriocarcinoma cells. 2146 71