Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0596263 (carcinogenesis)
 64,820 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Induction of thymomas by methylnitrosourea in many strains of mice requires 3 "hits". AKR mice develop thymomas spontaneously late in life, probably because of their large load of viral leukemia oncogenes. It was expected therefore, and so found, that methylnitrosourea induces thymomas in AKR mice with only 1 or 2 "hits". The viral oncogene therefore appears to function as a dominant "hit" gene cooperating with the chemical carcinogen.
Carcinogenesis 1980 Aug
PMID:Methylnitrosourea induction of thymomas in AKR mice requires one or two "hits" only. 1127 26