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Query: UMLS:C0596263 (carcinogenesis)
 64,820 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Young (3 month-old) and old (14 month-old) female outbred rats received a single i.p. dose (13 mg/kg) of N-[14C]methyl-Nacetoxymethylnitrosamine [( 14C]DMN-OAc), which, under these conditions, selectively induces intestinal tumours. Complete DMN-OAc breakdown occurred within 30 min in both young and old rats but exhalation of 14CO2 continued for over 1 h in young rats and over 3 h in old rats. The highest level of methylation in both young and old rats was found in the DNA of epithelial cells of the colon and in other adjacent abdominal organs (liver and uterus). The initial capacity for excision of the O6-methylguanine from liver DNA was greater in young animals, but further this DNA adduct was repaired more efficiently by the liver of old rats. In the DNA of ileal and colonic enterocytes, O6-methylguanine excision was higher in young than in old animals. The DNA tertiary structure, measured by the sedimentation pattern of nucleoids in neutral sucrose gradient, was damaged in old rats, and, to a lesser extent, in young rats. The non-uniform pattern of DNA damage in young and old animals may be associated with differing carcinogenic effects of DMN-OAc in rats of different ages, a hypothesis which is currently under test.
Carcinogenesis 1983 Aug
PMID:Carcinogenesis and aging. II. Modifying effect of aging on metabolism of methyl(acetoxymethyl)nitrosamine and its interaction with DNA of various tissues in rats. 687 55

This article is a review of the literature on the subject, which has been very little studied. 7 works in Russian and 33 in various Western languages are analyzed, from the point of view of the carcinogenic effects of various types of oral contraceptives on the uterus, cervix, ovaries, and breasts. About 20 instances are mentioned of liver cancer developing in women. The authors note the possibility of transplacental carcinogenesis in view of the fact that the daughters of women who took diethylstilbestrol to prevent spontaneous abortion were in some cases found to be suffering from adenocarcinoma of the vagina 15-20 years later. Other topics discussed are teratogenicity, the effects of OCs on women older than 40, therapeutic uses of OCs, and the need for careful follow-up of women who are using OCs.
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PMID:[Oncological aspects of hormonal contraception]. 701 84

The influence of feeding a pharmacological level of either selenium (SE), retinyl acetate (RA), or selenium and retinyl acetate (SE + RA) on N-methyl-N-nitrosourea-induced mammary carcinogenesis was studied in female Sprague Dawley rats. Rats received 50 mg N-methyl-N-nitrosourea per kg body weight at 50 days of age. Seven days after carcinogen treatment, groups of 25 rats each were placed on laboratory chow diet supplemented with either a placebo or 300 mg RA, 4 mg SE, or 300 mg RA plus 4 mg SE per kg diet. Animals were palpated for detection of mammary tumors twice each week, and the study was terminated 130 days after N-methyl-N-nitrosourea was given. In comparison to the placebo group, treatment with RA or RA + SE reduced tumor incidence, lessened the average number of tumors per rat, and prolonged tumor latency. RA + SE had the greatest inhibitory effect on the carcinogenic process. The effect of combined treatment with RA and SE was additive in nature. The length of the estrous cycle was increased by treatment with RA + SE, and some pathological changes of the ovary and uterus were noted. This investigation provides the first evidence of an additive inhibitory effect resulting from combined treatment with RA and SE.
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PMID:Effect of combined selenium and retinyl acetate treatment on mammary carcinogenesis. 719 39

The observations on the effect of 3 agents--1,4-dinitrosopiperazine, betel nut and saccharin fed to C17 mice in combination is presented in this report. A total of 119 inbred mice of both sexes were put on long-term feeding trials. Group I consisted of 34 mice given a standard diet; group II of 32 mice fed an experimental diet containing saccharin coated betel nut powder at 10% concentration; group III of 29 mice given 0.2 ml aqueous solution of 0.1% 1,4-dinitrosopiperazine by intubation daily and group IV of 24 mice fed a combination of the experimental diet together with intubation of 1,4-dinitrosopiperazine. Feeding was continued for 40 weeks at which time all mice were given a standard diet and water ad libitum, and then observed for their full life-span. The commonest neoplasm found was squamous cell carcinoma of the forestomach in groups III and IV. Male mice were more susceptible to the treatment than female mice. In female mice reticular cell neoplasm--Type A of the uterus was the commonest tumour and was more common in group III than in group IV. The diet of saccharin coated betel nut failed to potentiate the carcinogenicity of 1,4-dinitrosopiperazine.
Carcinogenesis 1981
PMID:Long-term feeding study in C17 mice administered saccharin coated betel nut and 1,4-dinitrosopiperazine in combination. 727 2

The carcinogenic activity of ethyl methanesulphonate (EMS), an alkylating agent and a potent mutagen, was examined in Wistar King A and Sprague Dawley rats following oral administration. In the Wistar King A rats, mammary carcinomas were detected in all of the young female rats by the 32nd week after initiation of the experiment. To determine the optimal experimental conditions for the rapid and invariable induction of mammary carcinomas, the relationship among age, sex, strain of the rats and concentration and duration of EMS administration, and tumor production was investigated. The tumor incidence was higher in the younger female rats and the Wistar rats were more susceptible than Sprague-Dawley rats. Mammary carcinomas were also induced in the younger male rats. In addition, concommitant production of renal tumors occurred by the 40th week in young rats administered 10(-2) M or 2 x 10(-2) M of EMS solution, while renal and uterine tumors developed concommitantly in the older female rats given 3 x 10(-3) EMS by the 56th week. Histologically, the prevailing features of tumors were infiltrating ductal adenocarcinoma in the mammary glands, mesenchymal tumor in the kidney, and leiomyosarcoma in the uterus. Methyl methanesulphonate, an analogue of EMS, did not induce tumors in any organs.
Carcinogenesis 1981
PMID:Mammary carcinoma induced by oral administration of ethyl methanesulphonate. Determination of some of the parameters affecting tumor induction. 732 21

To further understand hormonal carcinogenesis of natural estrogens (estrone, 17 beta-estradiol (E2) and estriol), we determined the expressions of c-fos/jun mRNA, and their oncoproteins (Fos/Jun) with intracellular localization in the uterus of ovarectomized mice treated with these estrogens. Mid-term chronic, as well as short-term assays were examined. Of three estrogens examined, mid-term chronic E2-treatment significantly increased the expression of c-fos/jun mRNA, and their oncoproteins (Fos/Jun). These were most prominently expressed in glandular cells of E2-treated mouse endometrium. Therefore, mid-term chronic E2-treatment might partially induce glandular cell transformation of uterine endometrium via overexpression of Fos/Jun.
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PMID:Overexpressions of c-fos/jun mRNA and their oncoproteins (Fos/Jun) in the mouse uterus treated with three natural estrogens. 749 67

A new monoclonal antibody (Moab), 3H2, was produced by immunizing Balb/C mouse with EI, a newly established human cell line from moderately differentiated endometrial adenocarcinoma of the uterus. The molecular weight of the Moab 3H2-defined antigen was 36,000 daltons, and suggests that the epitope of the Moab 3H2-defined antigen was protein moiety. Moab 3H2 was of the IgG1, subclass. Using formalin-fixed, paraffin-embedded human tissues and immunohistochemical techniques (ABC method), Moab 3H2 has demonstrated reactivity, Moab 3H2 reacted with well and moderately differentiated endometrial adenocarcinoma of the uterus, but did not react with poorly differentiated endometrial adenocarcinoma of the uterus, Moab 3H2 did not react with other tissues, malignant or normal, except ovarian clear cell adenocarcinoma, suggesting that Moab 3H2 reacts with well and moderately differentiated endometrial adenocarcinoma of the uterus with high specificity. To analyze the epitope of the Moab 3H2-defined antigen, it should be useful to make clear the function of carcinogenesis, differentiation and growth of endometrial adenocarcinoma of the uterus.
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PMID:[Development of the monoclonal antibody to cultured uterine endometrial adenocarcinoma cells (EI)]. 763 34

Selenium (Se) concentration in serum, hair, normal cervix tissue or tissue of cervix cancer of 20 cases with cancer of uterine cervix (survey group), 21 with myoma of the uterus and 1 with cervical polys (control group), but also in rice, water and soil in the high and low incidence areas of cervical cancer was determined. The results showed that Se concentration in serum and cancer tissue of uterine cervix in patients with cancer of uterine cervix was significantly lower than that in the control group (P < 0.05), but no significant difference of Se concentration in hair was observed (P > 0.05), However Se concentration in rice, water and soil in the high incidence areas of cervical cancer was significantly lower than that in the low incidence areas (P < 0.05). Se deficiency may play a role in the carcinogenesis of uterine cervix.
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PMID:[Relation between selenium and cancer of uterine cervix]. 765 99

We recently described the establishment and the characterization of two rat endometrial adenocarcinoma cell lines which we called RUCA-I and RUCA-II. Despite fairly high estrogen receptor levels neither cell line responded to estradiol in conventional cell culture conditions on plastic and in the presence of serum. A limited hormonal response to the antiestrogen tamoxifen was detectable in RUCA-I but not in RUCA-II cells. To advance our cell culture conditions we plated RUCA-I cells on a layer of reconstituted basement membrane (Harbor Matrix) in the presence of a serum-free defined medium. These cell culture conditions induced hormone responsiveness of RUCA-I cells and permitted a stimulation of proliferation by estradiol. Further, two estradiol-induced secretory proteins with an apparent molecular weight of 115 kD and 60 kD could be identified by SDS-gelelectrophoresis if analyzed under reducing conditions. These proteins migrated as a single band in a non-reducing electrophoresis gel and were identified as components of the complement C3 system. Additionally, our results suggest that the effects of extracellular matrix and hormones on the expression of these proteins are additive. We conclude that processes of functional differentiation are most likely to occur in this in vitro model, particularly since the expression of components of the complement C3 system was under estrogenic control. Complement C3 proteins represent major estradiol-inducible secretory protein of the immature rat uterus in vivo. Culturing RUCA-I cells on top of a layer of reconstituted basement membrane provides a novel tool to study the importance of the extracellular environment on the hormone-induced gene expression in endometrial carcinogenesis in vitro.
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PMID:Extracellular matrix induces hormone responsiveness and differentiation in RUCA-I rat endometrial adenocarcinoma cells. 769 47

The present study examines the modulatory influence of the combined oral contraceptive pill, Ovral (0.05 mg ethynylestradiol plus 0.25 mg levonorgestrel per pill) on methylcholanthrene (MCA)-induced carcinogenesis in the uterus of Swiss albino mouse. Placement of cotton thread impregnated with beeswax containing approximately 600 micrograms of MCA, yielded endometrial squamous cell carcinomas in 53.33% animals in 90 days. Concomitant treatments with doses D1 (1/200th of a pill) and D2 (1/200th of a pill) of Ovral yielded endometrial squamous cell carcinomas in 6.23 and 0% of animals in 90 days (p < 0.05; p < 0.005) respectively. Ovral did not seem to increase the incidence of uterine hyperplasia.
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PMID:Modulatory influence of the oral contraceptive pill, Ovral, on 3-methylcholanthrene-induced carcinogenesis in the uterus of mouse. 780 Mar 39


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