Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0595921 (intraocular pressure)
 11,750 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Prazosin hydrochloride, an oral antihypertensive, is reported to inhibit phosphodiesterase and block postsynaptic alpha-adrenergic receptors, intraocular pressure (IOP) in rabbits was reduced in a dose-related manner following topical ocular application of concentrations of 0.0001% to 0.1%. The ocular hypotensive response lasted six to eight hours with a maximum effect at approximately two hours. The IOP of unilaterally sympathectomized rabbits treated in both eyes with prazosin decreased more in the normal eyes than in the sympathectomized eyes. Treatment of only the unsympathectomized eyes of these rabbits elicited a similar response. Normal rabbits elicited a similar response. Normal rabbits treated in only one eye also showed a slight response in the contralateral eye. Preliminary experiments did not support the hypothesis that these effects were due to a decrease of systemic blood pressure. No substantial ocular toxicity or pupillary changes were observed.
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PMID:Influence of topically applied prazosin on the intraocular pressure of experimental animals. 48 19

Prazosin hydrochloride, a systemic antihypertensive agent, lowers intraocular pressure when applied topically to normal rabbit eyes. A 0.01% solution of topically administered prazosin did not alter out-flow facility, episcleral venous pressure, systemic blood pressure, or ocular blood flow. Tonography suggested a 27% decrease in the rate of aqueous humor formation two hours following topical administration. Posterior chamber aqueous ascorbate levels were increased following topical administration of prazosin, which also suggested a decreased entry rate of water into the eye. The effect of prazosin on IOP was prevented by systemic pretreatment with phentolamine mesylate, an alpha-adrenergic blocking agent, but not by propranolol hydrochloride or atropine sulfate. This was consistent with the known action of prazosin as a postsynaptic alpha-adrenergic blocking agent.
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PMID:Effect of prazosin on aqueous humor dynamics in rabbits. 742 28