Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0595921 (intraocular pressure)
 11,750 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of propranolol (Inderal) on the intraocular pressure (IOP) in glaucoma has been measured. Twenty-two patients completed the clinical trial. Propranolol in doses of 160 mg/d effectively lowered IOP in eyes with various types of open angle glaucoma. The test periods lasted from 4 to 6 days. The ocular hypotensive effect of propranolol was also registered in patients efficiently treated with pilocarpine and acetazolamide (Diamox), and in glaucomas not satisfactorily controlled by this therapy. High positive correlations between mean pretreatment pressure (P1), and pressure fall (delta P) were found (P less than 0.001), and the pressure decrease induced by propranolol treatment tended to be proportional to the pressure gradient between the anterior chamber and the episcleral veins. This pressure gradient was reduced by an average of about 50% following propranolol treatment. There was no change in scleral rigidity after propranolol.
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PMID:The treatment of glaucoma with propranolol (Inderal). A clinical trial. 78 44

Placebo and propranolol (Inderal) in doses of 20, 40, and 80 mg were given in a single-blind test to two groups of six ocular hypertensives. The groups consisted of patients with an intraocular pressure ranging from 20 to 29 mmHg and 30 to 39 mmHg. The doses were given 48 hours apart and administered after fasting 12 hours. IOP by Goldmann applanation tonometer, systemic blood pressure and pulse rate in the supine position were recorded hourly before and after administration. In both groups a decrease in mean IOP was noted after one hour and this reduction reached its maximum three hours after the administration of propranolol. The absolute reduction was greater in the group with the highest initial IOP and in both groups the fall in mean IOP showed a clear dose-dependent correlation. The simultaneous mean decrease in pulse rate was also dose-correlated, but reached its maximum two hours after administration. The fall in systemic blood pressure was only moderate and showed no obvious dose-dependence.
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PMID:Early dose response analysis of ocular hypotensive effects of propranolol in patients with ocular hypertension. 79 56