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Query: UMLS:C0595921 (intraocular pressure)
 11,750 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Corneal blood staining was established in the rabbit cornea by injecting autologous, citrate-buffered blood in the anterior chamber. Increased intraocular pressure was maintained above 30 mm of Hg by self-sealing trans-limbal injections repeated every 12 hours. Typically, corneal edema developed in 3 days, followed several days later by a red discoloration that turned brown about 2 days later. Histopathologically, the edematous cornea disclosed endothelial swelling and attenuation with marked stromal edema. Histochemically, the red-stained cornea disclosed only extracellular hemoglobin particles; the brown-stained corneas showed extracellular and intracellular hemoglobin particles as well as intracellular hemosiderin in keratocytes. Spectrophotometric analysis of the keratectomy specimens suggested the presence of porphyrins in all stages of blood staining, including the edematous cornea. Oxyhemoglobin was found in red-stained corneas, while methemoglobin was present in the brown-stained corneas. It was concluded that endothelial degeneration uniformly accompanied corneal blood staining in this model and that keratocytes are actively involved in hemoglobin degradation.
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PMID:Corneal blood staining. An animal model. 373 24

After sustaining blunt ocular trauma and total hyphemas, two patients quickly developed corneal blood staining in the absence of elevated intraocular pressure. Corneal blood staining has previously been reported to occur in association with hyphema and raised intraocular pressures. Although several bibliographic references acknowledge that corneal blood staining may occur without raised pressure, a careful review of the literature failed to reveal any well-documented cases.
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PMID:Corneal blood staining at low pressures. 399 74

We reviewed the medical records of 11 consecutive patients who underwent trabeculectomy with anterior chamber washout and peripheral iridectomy as the primary surgical treatment for traumatic hyphema that was unresponsive to medical management. The mean intraocular pressure before surgery was 48 mm Hg. In ten of the patients the intraocular pressure was lowered to 21 mm Hg or lower after surgery and remained below that level up to the most recent follow-up visit, which ranged from eight to 97 months. One patient required a topical beta-blocker and oral acetazolamide to lower pressure to this level after surgery. Eight patients had visual acuity of 20/60 or better at last follow-up. Corneal blood staining occurred in eight patients. Compared with other techniques for surgical management of traumatic hyphema, trabeculectomy provides a means to keep intraocular pressure lowered while the remaining blood is clearing from the anterior chamber. Trabeculectomy with anterior chamber washout and peripheral iridectomy appears to be a safe and reliable procedure in the management of traumatic hyphemas in which medical management fails to control intraocular pressure.
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PMID:Trabeculectomy for traumatic hyphema with increased intraocular pressure. 811 42