Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0595921 (intraocular pressure)
 11,750 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A study comparing tubocurarine and pancuronium for precurarization indicates that either successfully attenuates fasciculation after succinylcholine administration. However, if the aim is to prevent or attenuate such side effects of succinylcholine as cardiac arrhythmias, hyperkalemia, and increased intraocular pressure, there is as yet no proof that pancuronium will be effective in these areas.
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PMID:"Precurarization" using pancuronium. 116 64

The influence of diazepam on some adverse effects of succinylcholine was studied double-blind. Thirty patients (ASA I-II) were allocated to groups receiving either diazepam 0.08 mg/kg or d-tubocurarine 0.05 mg/kg 5 min before a bolus of succinylcholine, 1 mg/kg and 1.5 mg/kg, respectively. Fasciculations were more frequent in the diazepam group (80%) than in the d-tubocurarine group (13%). Relaxation, onset and duration of neuromuscular blockade were comparable in the two groups. The rise in intraocular pressure after succinylcholine and endotracheal intubation was small (0.27 kPa = 2 mmHg) but significant (P less than 0.01) after diazepam pretreatment. In this group the rise in intraocular pressure was 50% lower than the rise seen in the d-tubocurarine group (P less than 0.01). We conclude that pretreatment with diazepam 0.08 mg/kg will reduce but not prevent a rise in the intraocular pressure after succinylcholine in a rapid sequence induction. In the management of patients with penetrating eye injuries the use of succinylcholine still carries some risk even after diazepam pretreatment.
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PMID:The effect of diazepam pretreatment on the succinylcholine-induced rise in intraocular pressure. 389 14