Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0595921 (intraocular pressure)
 11,750 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Long-term experience with transscleral cyclophotocoagulation in 500 patients suggests that this operation is the cyclodestructive procedure of choice. It offers a reasonable surgical option in the high-risk glaucoma population, which includes patients with neovascular glaucoma, glaucomas with active uveitis, glaucomas in aphakia or pseudophakia, and other cases in which filtering surgery has failed or is felt to have a low chance for success. Satisfactory intraocular pressure reduction was achieved in 62% of the patients with one treatment session. After one or more repeated procedures in 21% of the study group, the final intraocular pressure was below baseline in 94%, with a mean final reduction of 24 mm Hg, which was judged to be adequate for 87% of the patients. However, visual loss remains a significant postoperative complication, with some degree of reduced vision occurring in 39% of the study population. Patients with neovascular glaucoma had the greatest percentage of visual loss at 46%, compared with 34% and 38% for patients with glaucomas in pseudophakia and aphakia, respectively. While it is hard to know how many of these cases of visual loss were a direct result of the cyclophotocoagulation, the procedure should be used with caution in eyes with a potential for good central vision. Further study is needed to determine the relative indications for transcleral cyclophotocoagulation and the various operations to increase aqueous outflow in the management of patients in the high-risk glaucoma population.
 ...
PMID:Noncontact transscleral Nd:YAG cyclophotocoagulation: a long-term follow-up of 500 patients. 788 67

Between 1985 and 1993, 73 eyes of 56 uveitis patients were subjected to extracapsular (n = 64) or intracapsular (n = 9) cataract extraction. We investigated the results up to 6 years later. 53 eyes received a posterior chamber lens, one an anterior chamber lens. Preoperatively, 22 eyes showed signs of an inflammation in the anterior chamber. Nevertheless, we implanted posterior chamber lenses in 16 of them. In most cases posterior synechias made the lens extraction more difficult, but no complications occurred. Twenty-four eyes, 17 of them with a posterior chamber lens, showed a new uveitis during follow-up which was treated conservatively. The intraocular pressure was not well regulated during follow-up in 4 of 15 eyes with preoperatively known secondary glaucoma. Two more secondary glaucomas developed. The visual acuity was satisfactory, and late diminutions were not caused by the uveitis in most cases. No artificial lens had to be explanted.
 ...
PMID:[Late results of cataract operation with and without lens implantation in patients with uveitis]. 795 Jan 18

Fifteen patients with "bound down" pupil or ring synechiae associated with chronic granulomatous uveitis in whom dilatation could not be obtained pharmacologically underwent iris-lens synechiolysis using relatively low energies from a Q-switched Nd:YAG laser. Pupil size increased significantly in all of the treated eyes; visual acuity improved in 40%. Postlaser elevated intraocular pressure developed in a significant number, but there were no serious long-term complications associated with the procedure. Although acuity improved in less than half of the patients, because this laser treatment is relatively safe and offers some possibility of visual improvement, we recommend it for routine use, but only if performed by an experienced laser microsurgeon.
 ...
PMID:Neodymium: YAG laser iridolenticular synechiolysis in uveitis. 805 59

We describe a 49-year-old white man with sympathetic ophthalmia following contact neodymium-YAG laser cyclotherapy. There was no invasive surgery, and no perforating injuries preceded cyclodestructive therapy. The eye had hemorrhagic secondary glaucoma due to Coats' disease. It was treated three times with contact cyclophotocoagulation after cyclocryotherapy failed to lower intraocular pressure. Subsequently, the intraocular pressure slowly decreased and the eye became phthisical 15 months after the last surgery. Intraocular inflammation developed in the fellow eye and sympathetic ophthalmia was suspected. Histologic and immunohistologic study of the enucleated blind eye confirmed this diagnosis.
 ...
PMID:Sympathetic ophthalmia following laser cyclocoagulation. 828 99

A 31-year-old woman was shot with a toy bullet OD. Intracameral cells and fibrin were found, but no penetrating wound was noticed. Flare was observed in the left anterior chamber three days after the incident, and the intraocular pressure OS had increased. No specific type of uveitis or systemic inflammatory disease was identified. We believe that bilateral uveitis was precipitated in our patient by the nonpenetrating trauma.
 ...
PMID:Nonpenetrating trauma in the right eye induces anterior uveitis and secondary glaucoma in the contralateral eye. 836 96

We evaluated 30 consecutive patients with glaucoma treated with semi-conductor diode transscleral cyclophotocoagulation to determine the results and complications of this procedure. Twelve months after surgery the mean (+/- SD) preoperative intraocular pressure of 32.5 +/- 10.9 mm Hg (n = 30) had dropped to 20.8 +/- 15.6 mm Hg (n = 19) (P = .018, paired Student's t test), while the mean number of preoperative medications received decreased from 2.0 to 1.8 (P = .060, Wilcoxon's Signed Rank Test). One year after surgery three patients (10%) were unavailable for follow-up, eight (27%) had required other surgical procedures to control the intraocular pressure, 17 (56%) had controllable intraocular pressure of 21 mm Hg or below or received pain relief from the diode laser alone, and two (7%) patients with controlled intraocular pressure had suffered visual loss. Other complications included mild conjunctival hyperemia and uveitis in all patients and mild ocular pain in six patients. This study suggests the usefulness of diode transscleral cyclophotocoagulation in reducing the intraocular pressure for up to 1 year.
 ...
PMID:One-year results of semiconductor transscleral cyclophotocoagulation in patients with glaucoma. 847 Sep 80

We retrospectively examined 52 patients (60 eyes) with episcleritis and scleritis. Their mean ages were 57 and 47 years, respectively. Slight female predominance was noted. Most patients had unilateral involvement. The ocular symptoms at the initial visit were redness and ocular pain. Some eyes with scleritis were complicated with uveitis, corneal lesions, and elevated intraocular pressure. In most affected eyes, corticosteroid eyedrops alone resolved the disease. We believe that in addition to ophthalmological examinations, standard physical and specific laboratory investigations should be performed in patients with episcleritis and scleritis.
 ...
PMID:Clinical features of episcleritis and scleritis in some Japanese patients. 857 Jan 48

The long-term results obtained with the Krupin eye short valve shut in 28 eyes with neovascular glaucoma were retrospectively analyzed by means of Kaplan-Meier survival curve. The preoperative intraocular pressures (IOPs) ranged from 28 to 62 mm Hg (mean, 36.8 +/- 5.8 mm Hg). Success was considered an IOP of less than 22 mm Hg and greater than 5 mm Hg without medication (complete success) or with medication (qualified success) without additional glaucoma filtering surgery or devastating complications. Postoperative success was obtained in 10 out of 28 eyes after a mean follow-up period of 58.4 +/- 23.02 months (range, 10-108 months). The 3- and 6-year life table success rates were 66 and 34%, respectively. Early complications were: shallow or flat anterior chamber (15 patients, 53.6%), hypotony (16 patients, 57.1%), hypertony (7 patients, 25%), serous choroidal effusion (7 patients, 25%), fibrinous uveitis (5 patients, 17.9%), blockage of the intracameral portion of the tube by fibrin (5 patients, 17.9%), choroidal hemorrhage (2 patients, 7.1%). Late complications were: external conjunctival bleb failure (12 patients, 42.9%), blockage of the intracameral portion of the tube by fibrovascular tissue (5 patients, 17.9%), cataract (2 patients, 7.1%), bullous keratopathy (2 patients, 7.1%), external erosion of the Silastic valve (2 patients, 7.1%), phthisis bulbi (2 patients, 7.1%). Mortality during long-term follow-up was high in our series. The complications of an underlying diabetes mellitus were the most common cause of death (15 out of 22 patients). The high mortality of patients subjected to valve implantation makes it difficult to interpret the results of long-term studies. However, the valve implant is still today an alternative surgical procedure for controlling IOP in eyes with neovascular glaucoma that have visual potential.
 ...
PMID:Long-term results of Krupin-Denver valve implants in filtering surgery for neovascular glaucoma. 884 Oct 66

Raised intraocular pressure is a common and frequently serious complication of anterior uveitis. The milieu of inflammatory cells, the mediators they release, and the corticosteroid therapy used to treat the uveitis can participate in the pathogenesis of uveitic glaucoma. These factors alter the normal anatomic structure of the anterior chamber and angle, influencing aqueous production and outflow. These changes act to disrupt the homeostatic mechanisms of intraocular pressure control. Structural changes in the angle can be acute, such as in secondary angle closure with pupillary block glaucoma, or chronic, such as combined steroid-induced and secondary open angle glaucoma. Management of uveitic glaucoma may be difficult because of the numerous mechanisms involved in its pathogenesis. Diagnostic and therapeutic decisions are guided by careful delineation of the pathophysiology of each individual case. The goal of treatment is to minimize permanent structural alteration of aqueous outflow and to prevent damage to the optic nerve head. This article reviews the pathogenesis of uveitic glaucoma, with specific attention to etiology. Medical and surgical therapies are also discussed, with emphasis on the more recent developments in each category.
 ...
PMID:Glaucoma associated with uveitis. 916 35

The aim of this study is to compare complication rates in two different operative techniques applied for the secondary, posterior chamber intraocular lens (PCIOL) implantation with sulcus fixation. 179 eyes with partial or no posterior capsule support underwent surgery. Applied techniques were: transscleral fixation of the IOL by passing with the fixation needle through the sulcus from the inside (70 eyes) or from the outside (109 eyes) of the bulbus. The most frequent intraoperative complications were haemorrhages and vitreous prolaps with no significant difference between used techniques. In the 'from the inside' group, following late postoperative complications developed: astigmatism of > 4D (24%), cystoid macular oedema (20%), pupil distortion (14%), partial posterior capsule opacification (10%), suture exposure (10%), IOL decentration (8%) and hemophthalmus (3%). In the 'from the outside' group same complications showed a decreased rate: 17%, 16%, 8%, 8%, 9%, 5% and 1%, respectively. Other late complications like high intraocular pressure, synechiae and uveitis were adequately represented in both techniques. After 24 months follow-up, best corrected visual acuity > or = 0.8 was achieved in 48.5% of eyes when 'from the inside' and in 57.7% of eyes when 'from the outside' technique was used.
 ...
PMID:Complications following two methods of posterior chamber intraocular lens suturing. 918 39


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>