Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0546837 (esophageal cancer)
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Human Gene/Protein
deleted in lung cancer 1 11.8
EC45 11.8
Cysteine-rich C-terminal 1 11.8
FAM135B protein 11.8
SASS6 protein 11.8
hCLA-iso 11.8
POTEG 11.8
POTE ankyrin domain family, member G 11.8
zinc finger protein 207 11.8
GKAP1 10.8
PLCE1 protein 10.8
FLJ11021 10.8
MAPK1IP1L 10.8
SEC14L 10.8
V-set and immunoglobulin domain containing 1 10.8
P311 HUM 10.8
CTAG1 10.8
LOC440173 10.8
heat shock 70 kDa protein 9B 10.8
EMILIN-5 10.8
TM4SF3 10.3
p21-activated kinase 7 10.2
CCDC116 10.2
phosphodiesterase 4D interacting protein 10.2
N-myristoyltransferase 2 10.2
ECRG1 10.2
serine/threonine kinase 31 10.2
LRFN1 10.2
15-hydroxyprostaglandin dehydrogenase [NAD+] 9.8
deleted in esophageal cancer 1 9.8
ECRG2 9.8
receptor associated protein 80 9.8
DZIP1L 9.8
RNF217 9.8
RGS22 9.8
KIAA1244 9.8
squamous cell carcinoma antigen 2 9.8
C2orf40 9.8
GTF2H3 9.8
SLITRK4 9.8
PRKRIR 9.8
Histone deacetylase 10 9.8
Ly110 9.8
MANA 9.6
RHBDF2 9.6
ORAOV1 9.6
phospholipase C epsilon 1 9.5
RSRC2 9.5
retinoic acid induced 14 9.5
eyes absent 4 9.5
EIF3J 9.5
CT47 9.5
hRFI 9.5
ANKRD6 9.5
mixed lineage kinase 4 9.5
PFTAIRE protein kinase 1 9.2
RAB15 9.2
EPGN 9.2
METTL7B 9.2
Desmocollin 2 9.2
TE2 9.1
HA synthase 3 9.0
TBRG4 9.0
RAP2C 9.0
UBL3 9.0
CACYBP 9.0
FAM135B 9.0
FOXR1 9.0
CCNG2 protein 9.0
fragile histidine triad gene 8.9
FAM84B 8.9
ECRG4 8.9
PLCE1 8.8
SH3 domain-binding protein 1 8.8
P2P-R 8.8
SASS6 8.8
pre-B-cell leukemia homeobox 1 8.8
C20orf54 8.7
KCNJ18 8.6
RPL34 8.6
more...
Disease
esophageal cancer 11.8
Pleurocutaneous fistula 11.8
Chronic pericardial constriction 11.8
esophageal cancer 11.8
stage I esophageal cancer 11.5
recurrent esophageal cancer 11.1
metastatic esophageal cancer 10.9
Neoplastic pericarditis 10.8
NEPPK 10.8
respiratory neoplasm 10.8
ceruminosis 10.8
chronic alcohol problem 10.8
Multiple actinic keratoses 10.2
Molybdenum deficiency 10.2
Adenocarcinoma of the gastroesophageal junction 10.2
recurrent hypopharyngeal cancer 10.2
upper GI cancer 9.8
Pulmonary sepsis 9.8
Esophageal squamous cell carcinoma 9.8
tylosis 9.7
Esophagus 9.5
Esophagus 9.5
Deficiency Disease 9.5
Esophageal adenocarcinoma 9.3
cancer seeding 9.2
Chemoradiation 9.0
carcinoma of the esophagus 9.0
Tracheal diverticulum 8.9
digestive neoplasm 8.8
Postoperative stricture 8.8
Esophageal 8.7
Garcin's syndrome 8.5
Multiple cancer 8.3
Radiation esophagitis 8.2
Chronic esophagitis 8.1
mediastinal cancer 8.0
Barrett's esophagus 8.0
locally advanced cancer 8.0
Postoperative pneumonia 7.9
Respiratory morbidity 7.9
Squamous dysplasia 7.9
Non-occlusive mesenteric ischemia 7.8
tracheal cancer 7.8
Postoperative depression 7.7
pharyngeal cancer 7.7
hypopharyngeal cancer 7.7
Recurrent laryngeal nerve palsy 7.6
Myeloid metaplasia 7.6
esophageal stricture 7.5
gastrointestinal cancer 7.4
Esophageal leiomyoma 7.3
Gastric Carcinoma 7.3
Mediastinum 7.3
Mediastinum 7.3
Virchow's node 7.3
Alkaline reflux gastritis 7.3
Hypopharynx 7.3
small bowel cancer 7.2
Gastric perforation 7.1
Phlegmonous gastritis 7.1
Basaloid squamous cell carcinoma 7.0
Primary liver cancer 7.0
squamous cell carcinoma 7.0
lymphatic cancer 6.9
Carcinoma cuniculatum 6.8
Cardia 6.8
Renal metastasis 6.7
Catastrophic Illness 6.7
esophagitis 6.7
Epithelial dysplasia 6.7
pyothorax 6.6
dysphagia 6.6
residual cancer 6.6
OPA3 6.6
Dietary zinc deficiency 6.6
premalignant condition 6.5
Plummer-Vinson syndrome 6.5
pylorospasm 6.4
Reflux esophagitis 6.4
recurrent cancer 6.4
more...
Symptom
Frozen gait 10.2
Floppy 6.8
stomach distension 6.4
epigastric distress 6.2
painful swallowing 5.8
No toxic effect 5.5
abdominal fullness 5.1
heartburn 4.8
acid regurgitation 4.4
Regurgitation 4.3
hoarseness 4.3
aphagia 4.2
chyluria 4.2
bradypnea 4.2
belching 4.1
inanition 4.0
orthopnea 4.0
epigastric pain 4.0
halitosis 3.6
cachexia 3.5
anorexia 3.4
decreased appetite 3.2
nausea and vomiting 3.2
breakthrough pain 3.1
Respiratory symptoms 2.9
nausea 2.9
vomiting 2.8
regurgitation 2.7
Anoxia 2.7
hypoproteinemia 2.7
dyspnea 2.6
excessive sweating 2.6
flushing 2.6
Fluctuation 2.6
neck stiffness 2.6
hemoptysis 2.5
colic 2.5
drooling 2.4
leg edema 2.4
cough 2.4
chest pain 2.4
flank pain 2.3
stridor 2.2
discomfort 2.2
discomfort 2.1
asthenia 2.0
clubbing 2.0
muscle cramps 2.0
respiratory distress 1.9
otalgia 1.8
numbness 1.8
paresis 1.6
diarrhea 1.5
Mills 1.5
tingling 1.5
shortness of breath 1.5
Wind 1.5
tonic-clonic seizure 1.4
hemiplegia 1.4
abdominal pain 1.4
fatigue 1.4
sore throat 1.4
analgesia 1.3
polyuria 1.2
despair 1.2
torticollis 1.1
bloating 1.1
abdominal discomfort 1.1
overweight 1.0
anesthesia 0.9
insomnia 0.8
chills 0.7
hepatosplenomegaly 0.7
polydipsia 0.7
weakness 0.6
wheezing 0.6
paresthesia 0.5
acidity 0.5
pain 0.5
ENT 0.4
more...
Drug
Peplomycin sulfate 10.8
Alvocidib 8.0
Lugol 7.9
CFPM 7.4
Heparin sodium 7.3
Sivelestat sodium hydrate 7.2
Lugol's solution 7.1
Vindesine 6.9
Vindesine 6.9
Doxifluridine 6.5
Hakka 6.5
Celebrex 6.4
Photofrin II 6.4
CEG 6.3
Sivelestat 6.2
CEG 6.1
Ethyol 6.0
Irinotecan 5.8
FMOX 5.8
Photofrin 5.4
Docetaxel 5.3
MINO 5.3
Areca 5.3
Azacytidine 5.2
Bosutinib 5.2
Immune globulin 5.2
Clove 5.1
Flavopiridol 5.1
Taxotere 5.1
Tarceva 5.0
Amifostine 4.9
Pertuzumab 4.8
Saha 4.7
Lipiodol 4.7
KAN 4.7
Vinorelbine 4.7
BLM 4.6
Xeloda 4.5
Podophyllum 4.4
2-Methoxyestradiol 4.4
Swainsonine 4.4
Filgrastim 4.3
Filgrastim 4.2
Hypaque 4.1
Mitomycin-C 4.1
Diamminedichloroplatinum 4.1
VCR 4.1
Spiegel 3.9
Cetuximab 3.9
Herceptin 3.8
Leucovorin 3.8
CDX 3.8
Taxol 3.7
Bestatin 3.6
Gefitinib 3.6
balanced salt solution 3.5
Indomethacin 3.5
CPT-11 3.5
Artesunate 3.4
CDX 3.4
CTC 3.3
Fulvestrant 3.3
Dalteparin 3.3
Erlotinib 3.3
Etoposide 3.2
Retinoic Acid 3.2
GEO 3.2
VCR 3.2
AGG 3.2
ALA 3.2
Pemetrexed 3.1
Ipilimumab 3.1
CTT 3.1
Serum albumin 3.1
Tocilizumab 3.1
CTC 3.1
Pregabalin 3.0
Epigallocatechin 3.0
G418 3.0
ADM 3.0
more...
Enzyme
nardilysin 5.8
ADH3 5.8
SNO 5.5
NADPH:quinone oxidoreductase 5.5
cancer procoagulant 5.2
DCF 5.2
uracil phosphoribosyltransferase 5.1
Lys-gingipain 5.0
aldehyde dehydrogenase 5.0
aldehyde dehydrogenase 5.0
rhomboid protease 5.0
aldehyde dehydrogenase 5.0
aldehyde dehydrogenase 4.8
caspase-7 4.8
caspase-7 4.8
stromelysin-3 4.8
dihydropyrimidine dehydrogenase 4.7
prostasin 4.6
protein disulfide-isomerase 4.5
aldehyde dehydrogenase 4.5
dihydropyrimidine dehydrogenase 4.5
NQO2 4.2
cysteine dioxygenase 4.0
ALDH 4.0
O-GlcNAc transferase 3.8
SOR 3.8
microsomal epoxide hydrolase 3.8
proline oxidase 3.7
GRK2 3.6
TSA 3.6
HDR 3.6
histone demethylase 3.5
orotate phosphoribosyltransferase 3.4
thymidine phosphorylase 3.4
caspase-9 3.3
polo-like kinase 1 3.2
legumain 3.2
PMT 3.2
thymidylate synthase 3.2
HCS 3.1
PARP 3.1
methylenetetrahydrofolate reductase 3.1
methylenetetrahydrofolate reductase 3.1
sulfite oxidase 3.0
caspase-3 3.0
matrix metalloproteinase 2 2.9
sulfite oxidase 2.9
alcohol dehydrogenase 2.8
luciferase 2.7
ADPase 2.7
HK2 2.7
CDH 2.6
MTD 2.6
caspase-8 2.5
lysyl oxidase 2.5
cysteine synthase 2.5
15-hydroxyprostaglandin dehydrogenase 2.5
ERK 2.5
arylalkylamine N-acetyltransferase 2.4
neutral sphingomyelinase 2.4
type III procollagen 2.4
MEK 2.4
E-2 2.3
ornithine decarboxylase 2.3
DNA methyltransferase 2.3
SOR 2.3
matrix metalloproteinase 9 2.3
aldehyde oxidase 2.3
CEP 2.3
AGT 2.2
APC 2.2
TMT 2.2
TAT 2.2
TACE 2.2
neutrophil elastase 2.1
methionine synthase 2.1
phosphoinositide 3-kinase 2.1
thymidine kinase 2.1
hypoxanthine-guanine phosphoribosyltransferase 2.1
PAT 2.1
more...
Compound
Pepleo 11.8
Pepleo 11.8
Pepleo 11.8
Pepleo 10.8
C21H27NO2 10.8
C24H14 9.8
C24H14 9.2
N-Nitrosothiazolidine 8.8
Diphyllin 8.8
Quinalizarin 8.3
C22H14 8.1
Ethyl gallate 8.1
Pingyangmycin 7.9
I-123 BMIPP 7.9
THP-ADM 7.8
C22H14 7.7
Nedaplatin 7.6
Eupafolin 7.6
Terrein 7.3
Benzo[k]fluoranthene 7.3
Benzo[b]fluoranthene 7.3
CI 100 7.3
Sakuranetin 7.2
Psoralidin 7.2
Liriodenine 7.0
NPRO 7.0
dibenzo[def,p]chrysene 6.9
nicotinohydrazide 6.9
Isoalantolactone 6.9
Oridonin 6.9
Radium-226 6.8
Cinobufagin 6.8
5-FU 6.7
Dimethylglycine 6.7
Troleandomycin 6.6
EPA ethyl ester 6.4
NPYR 6.4
Sterigmatocystin 6.3
Orientin 6.3
NDMA 6.3
NPIP 6.2
PPBP 6.2
Foscan 6.2
Hydrocodone 6.1
TNM 6.1
Pristimerin 6.1
Pristimerin 6.1
Pristimerin 6.1
Pristimerin 6.1
Photofrin II 6.1
2-TCA 5.9
Eupatilin 5.9
10-Hydroxycamptothecin 5.8
Perillyl alcohol 5.8
Perillyl alcohol 5.8
FB2 5.7
Garcinol 5.7
Fusaric acid 5.7
Fusaric acid 5.7
Fusaric acid 5.7
FAP 5.6
FAP 5.6
GML 5.6
Costunolide 5.6
Sphinganine 5.6
PNB 5.6
Docetaxel 5.4
4-methoxybenzaldehyde 5.4
4-methoxybenzaldehyde 5.4
SCC 5.4
4-methoxybenzaldehyde 5.4
4-methoxybenzaldehyde 5.4
4-methoxybenzaldehyde 5.3
4-methoxybenzaldehyde 5.3
Cepharanthine 5.3
picene 5.3
1-methylhistidine 5.3
Hesperetin 5.3
Dioscin 5.2
Dioscin 5.2
more...