Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0546837 (esophageal cancer)
 8,907 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 568
Mol 317
p53 302
TNM 153
nodal 143
caspase-3 97
FDG 92
cyclin D1 87
Bcl-2 82
AKT 77
E-cadherin 76
epidermal growth factor receptor 74
mTOR 55
PI3K 54
She 52
vascular endothelial growth factor 50
p21 50
cytokine 45
cage 45
albumin 43
EGFR 42
ERK 41
catenin 41
serum albumin 40
aldehyde dehydrogenase 40
SCC 38
cyclooxygenase-2 38
carcinoembryonic antigen 36
UTR 35
MAPK 33
HER2 33
histone 33
C-reactive protein 33
proliferating cell nuclear antigen 33
p16 33
kit 32
COX-2 31
epidermal growth factor 31
CCK 31
CRT 31
PARP 30
VEGF 29
ALDH2 29
hemoglobin 29
cancer susceptibility 28
survivin 28
CD8 28
tumor necrosis factor 27
tyrosine kinase 27
IL-6 27
MRI 25
proton pump 25
Ki-67 25
insulin 25
HLA 25
caspase-9 24
annexin V 24
candidate tumor suppressor 24
TNF 23
CEA 23
interferon 23
GSTM1 23
ERK1 23
EGF 23
interleukin-6 22
c-myc 22
Gen 22
ubiquitin 22
PD-L1 22
PD-1 22
beta-catenin 21
N-cadherin 21
vimentin 20
GSTT1 20
DCF 20
collagen 20
p38 20
Cyclin D1 20
bcl-2 19
CCND1 19
CD44 19
gene 4 19
CD4 19
ATP 19
C30 19
glycoprotein 19
matrix metalloproteinase 19
CYP1A1 18
c-Jun 18
p27 18
cytokeratin 18
MEK 18
APC 18
CDK4 18
CYP2E1 18
proteasome 18
reserved 18
c-Myc 17
endoplasmic reticulum 17
ROS 17
cyclin 17
pT1 17
pT3 17
polypeptide 16
IL-10 16
STAT3 16
cytochrome 16
IL-8 16
GSTP1 16
alcohol dehydrogenase 16
Pol 16
AS1 16
TE2 16
osteosarcoma 15
cytochrome c 15
MMP-9 15
DDP 15
MMP9 15
TCF 15
EAC 15
MMP-2 15
EMT 14
non-Hodgkin's lymphoma 14
H2AX 14
cyclin B1 14
fused 14
lymphoid 14
receptor tyrosine kinase 14
cyclin E 14
FAP 14
TGF-beta 13
MMP2 13
interleukin-2 13
putative tumor suppressor 13
IL-2 13
JNK 13
chemokine 13
inducible nitric oxide synthase 13
novel gene 13
extracellular signal-regulated kinase 13
caspase-8 13
gut 13
p65 12
methylguanine-DNA methyltransferase 12
PTEN 12
alpha-fetoprotein 12
INK4a 12
erbB-2 12
GSH 12
prealbumin 12
IFN 12
fibrinogen 12
fibronectin 12
glutathione S-transferase 12
mutant p53 12
CYP2A6 12
Fas 12
scratch 11
PIK3CA 11
LC3 11
more...
Disease
esophageal cancer 8907
esophageal cancer 8227
cancer 4388
tumor 2758
squamous cell carcinoma 1536
carcinoma 1007
adenocarcinoma 939
Esophageal 810
gastric cancer 706
metastases 612
Esophagus 612
Esophagus 612
carcinogenesis 459
dysphagia 426
lung cancer 403
Barrett's esophagus 381
Esophageal squamous cell carcinoma 337
dysplasia 296
breast cancer 258
colorectal cancer 253
tumorigenesis 231
tumor progression 210
tumor growth 206
gastroesophageal reflux disease 177
pancreatic cancer 173
pneumonia 172
carcinoma of the esophagus 170
primary tumor 165
esophagitis 163
colon cancer 140
liver cancer 129
hepatocellular carcinoma 125
liver cancer 114
head and neck cancer 113
gastrointestinal cancer 110
Esophageal adenocarcinoma 104
prostate cancer 96
melanoma 90
cervical cancer 87
malnutrition 78
obesity 77
lymphoma 72
bladder cancer 67
rectal cancer 66
leukemia 65
residual disease 64
achalasia 64
neutropenia 60
ovarian cancer 56
celiac disease 54
non-small cell lung cancer 54
sepsis 51
diabetes 49
esophageal stricture 47
sepsis 47
anemia 45
cirrhosis 44
West 41
respiratory failure 39
leukopenia 37
carcinoma in situ 36
metastatic esophageal cancer 36
depression 35
recurrent esophageal cancer 35
oral cancer 34
thrombocytopenia 34
Adenocarcinoma 32
chylothorax 31
renal cell carcinoma 30
liver metastases 30
reflux esophagitis 30
renal cancer 29
laryngeal cancer 29
glioma 28
Chemoradiation 28
thyroid cancer 28
myelosuppression 27
Thoracic 27
laryngeal cancer 27
ischemia 26
hypopharyngeal cancer 25
pulmonary edema 25
Helicobacter pylori infection 24
infectious diseases 24
aspiration pneumonia 24
DDP 23
tylosis 23
peptic ulcer 23
Hodgkin's disease 22
mesothelioma 22
solid tumor 22
skin cancer 22
gastritis 21
cancer recurrence 21
lung carcinoma 21
B-cell lymphoma 21
leiomyoma 20
hiatal hernia 20
lymphadenopathy 20
mediastinitis 20
residual cancer 20
empyema 20
MCF 19
APC 19
sarcoma 19
recurrent cancer 19
pharyngeal cancer 19
familial adenomatous polyposis 19
TEM 18
stroke 18
retinoblastoma 18
lung metastases 18
hypertension 18
aggressiveness 17
invasive cancer 17
osteosarcoma 17
Infection 16
alcoholism 16
non-Hodgkin's lymphoma 16
pericardial effusion 16
Gastric Cancer 16
endometrial cancer 16
AS1 16
aggression 16
systemic disease 16
myocardial infarction 15
osteoporosis 15
second cancer 15
heavy drinking 15
heart failure 15
premalignant condition 14
Nasopharyngeal carcinoma 14
hepatitis B 14
gastric ulcer 14
Epstein 14
dyspepsia 14
duodenal ulcer 14
EMT 14
pyothorax 13
atrophic gastritis 13
esophageal varices 13
biliary tract cancer 13
tumor initiation 13
papilloma 13
multiple myeloma 13
stomatitis 13
gallstones 13
alcohol abuse 13
brain metastases 13
gallbladder cancer 13
adult respiratory distress syndrome 13
heart disease 13
pericarditis 13
tuberculosis 13
chronic obstructive pulmonary disease 12
herpes simplex 12
hyperkeratosis 12
GSH 12
brain tumor 12
human papilloma virus 12
more...
Symptom
pain 100
vomiting 62
anesthesia 56
dyspnea 49
nausea 48
diarrhea 46
anorexia 42
fatigue 38
cough 35
discomfort 29
discomfort 28
chest pain 25
nausea and vomiting 24
abdominal pain 23
analgesia 20
respiratory distress 20
cachexia 18
heartburn 16
weakness 16
hoarseness 16
regurgitation 15
overweight 15
epigastric pain 15
flushing 11
hemoptysis 10
acidity 6
headache 6
collapse 5
insomnia 5
paresis 5
colic 5
numbness 5
abdominal fullness 4
exhaustion 4
back pain 4
shortness of breath 4
sleepiness 3
Ill 3
flank pain 3
asthenia 3
erythema 3
hemiplegia 3
splenomegaly 3
functional recovery 3
decreased appetite 3
hypothermia 3
stridor 3
tremor 3
constipation 3
polyuria 2
belching 2
sore throat 2
seizures 2
Wind 2
halitosis 2
hepatosplenomegaly 2
wheezing 2
spasm 2
chills 2
ENT 2
orthopnea 2
hypoproteinemia 2
angina 2
agitation 2
paresthesia 2
starvation 2
dizziness 2
chyluria 1
drooling 1
torticollis 1
despair 1
otalgia 1
inanition 1
HSA 1
bradypnea 1
Fluctuation 1
memory loss 1
excessive sweating 1
stomach distension 1
Mills 1
No toxic effect 1
ataxia 1
tingling 1
Respiratory symptoms 1
Floppy 1
Frozen gait 1
hepatomegaly 1
myalgia 1
neck stiffness 1
cancer pain 1
hunger 1
leg edema 1
painful swallowing 1
Regurgitation 1
neck pain 1
abdominal discomfort 1
polydipsia 1
lethargy 1
bloating 1
muscle cramps 1
acid regurgitation 1
syncope 1
aphagia 1
epigastric distress 1
Anoxia 1
clubbing 1
tonic-clonic seizure 1
breakthrough pain 1
Drug
Cardiovasc 153
ascorbate 32
Monit 29
Lugol 26
vitamin E 24
Docetaxel 20
Indomethacin 20
lysine 17
ROS 17
Irinotecan 13
IL-2 13
Taxol 12
Photofrin 11
Herceptin 9
ROC 9
BLM 9
IFN-gamma 8
ALA 7
ADM 7
G-CSF 7
Glutathione 6
niacin 6
CPT-11 6
Taxotere 6
Hypaque 6
Photofrin II 6
Lipiodol 6
CSF 5
balanced salt solution 5
Leaf 5
G418 5
Lugol's solution 5
Dermatol 5
Adriamycin 5
Ethanol 5
Vindesine 4
MRC 4
VCR 4
Vindesine 4
GEO 4
Cetuximab 4
ADR 4
Gefitinib 4
ENT 3
CTC 3
Vitamin E 3
ABC 3
Bevacizumab 3
VCR 3
Areca 3
nitroglycerin 3
Serum albumin 3
CTC 3
CAM 3
CTX 3
NAG 3
TAT 3
CTX 3
Activin 3
Amifostine 3
Etoposide 3
IL-1ra 3
CTX 3
Retinoic acid 3
Celebrex 3
Vinorelbine 3
uPA 2
Albumin 2
ACT 2
Asn 2
caffeine 2
citric acid 2
Erlotinib 2
Filgrastim 2
Mutagen 2
Flavopiridol 2
Leucovorin 2
IPM 2
Vitamin A 2
Ethyol 2
NH3 2
Hakka 2
EE2 2
Filgrastim 2
AGG 2
Tarceva 2
Paraffin 2
Oxaliplatin 2
AIC 1
Spectrum 1
CDX 1
Phosphatidylserine 1
Vitamin B12 1
PMEA 1
Methylene blue 1
Angiotensin II 1
Gelfoam 1
CEG 1
Imatinib 1
Emodin 1
Pemetrexed 1
Bestatin 1
ICI 1
Glycyrrhiza 1
Heparin sodium 1
Fentanyl 1
Acacia 1
Cremophor EL 1
p75 1
SiO2 1
Doxifluridine 1
Ginseng 1
Citric acid 1
MINO 1
Ganciclovir 1
BTC 1
Rosiglitazone 1
CEG 1
PFA 1
CTA 1
Pregabalin 1
Simvastatin 1
CTT 1
Fulvestrant 1
Triad 1
Dalteparin 1
Dial 1
Pertuzumab 1
2-Methoxyestradiol 1
Sorafenib 1
Triad 1
Spiegel 1
Mitomycin-C 1
Asthma 1
CDP 1
Ipilimumab 1
Tocopherol 1
Itraconazole 1
TAC 1
Retinoic Acid 1
Bosutinib 1
Imiquimod 1
Gel 1
CDX 1
ampicillin 1
NVP 1
Peplomycin sulfate 1
Raloxifene 1
Methylprednisolone 1
CFPM 1
Bifidobacterium 1
Gastro 1
TTC 1
MOF 1
KAN 1
CCL 1
Saha 1
Riboflavin 1
THF 1
ZnO 1
more...
Enzyme
ERK 146
mitogen-activated protein kinase 86
caspase-3 79
luciferase 71
aldehyde dehydrogenase 41
aldehyde dehydrogenase 41
aldehyde dehydrogenase 40
aldehyde dehydrogenase 40
aldehyde dehydrogenase 40
focal adhesion kinase 37
protein kinase 35
PARP 33
reverse transcriptase 30
MEK 26
APC 21
caspase-9 21
DCF 20
glutathione S-transferase 19
proteasome 18
alcohol dehydrogenase 18
protein kinase C 15
peroxidase 14
caspase-8 11
superoxide dismutase 10
ornithine decarboxylase 9
thymidine kinase 9
thymidylate synthase 9
dihydropyrimidine dehydrogenase 9
urokinase-type plasminogen activator 9
ATPase 8
cdc2 8
AMP-activated protein kinase 7
caspase-7 7
caspase-7 7
DNA methyltransferase 7
gamma-glutamyl transpeptidase 7
alanine aminotransferase 7
phosphoinositide 3-kinase 7
RNA polymerase 6
GSK 6
ACS 6
alkaline phosphatase 6
catalase 6
topoisomerase 6
succinate dehydrogenase 6
NQO1 6
DNA polymerase 5
methylenetetrahydrofolate reductase 5
methylenetetrahydrofolate reductase 5
dihydropyrimidine dehydrogenase 5
AMPK 5
plasmin 5
neutrophil elastase 5
topoisomerase 5
PAH 5
demethylase 5
ceruloplasmin 5
matrix metalloproteinase 2 5
SNO 5
glutathione peroxidase 5
IKK 5
AMPK 5
P-glycoprotein 5
trypsin 4
polo-like kinase 1 4
ALDH 4
TSA 4
collagenase 4
elastase 4
glutathione reductase 4
ADH3 4
GRK2 3
RNase 3
STR 3
lactate dehydrogenase 3
RNase 3
phosphatidylinositol 3-kinase 3
calcineurin 3
histone demethylase 3
creatine kinase 3
microsomal epoxide hydrolase 3
enolase 3
phospholipase C 3
TAT 3
matrix metalloproteinase 9 3
MMP 3
NADPH oxidase 3
thymidine phosphorylase 3
hypoxanthine-guanine phosphoribosyltransferase 3
NADPH oxidase 3
monoamine oxidase 3
transcriptase 3
ADH 2
PDK1 2
thrombin 2
pyruvate kinase 2
MDP 2
beta-galactosidase 2
peroxiredoxin 2
CYP3A4 2
tissue plasminogen activator 2
thromboplastin 2
carbonic anhydrase 2
DNase 2
urease 2
HDR 2
arginase 2
hexokinase 2
endonuclease 2
glyceraldehyde-3-phosphate dehydrogenase 2
phospholipase A2 2
urease 2
ribonucleotide reductase 2
O-GlcNAc transferase 2
kallikrein 2
MDR 2
glucose-6-phosphate dehydrogenase 2
cathepsin B 2
TdT 2
aspartate aminotransferase 2
acetylcholinesterase 2
lysyl oxidase 2
uracil phosphoribosyltransferase 2
pepsin 2
caspase-1 2
Lys-gingipain 1
indoleamine 2,3-dioxygenase 1
NOS 1
E-2 1
proline oxidase 1
lipoxygenase 1
SOR 1
apyrase 1
TACE 1
NQO2 1
ADPase 1
PAT 1
MTD 1
CPT 1
CPT 1
cysteine synthase 1
TMT 1
methionine synthase 1
cysteine dioxygenase 1
5'-nucleotidase 1
aldolase 1
neuraminidase 1
rhomboid protease 1
adenylate cyclase 1
histone acetyltransferase 1
protein phosphatase 2A 1
firefly luciferase 1
CPT 1
proteinase K 1
HK2 1
CEP 1
15-hydroxyprostaglandin dehydrogenase 1
glyceraldehyde-3-phosphate dehydrogenase 1
Alternating 1
prostate-specific antigen 1
more...
Compound
Clin 591
Dec 588
DNA 501
5-FU 207
TNM 153
MTT 124
water 105
oxygen 98
ethanol 95
Pac 71
glucose 69
iodine 68
barium 58
zinc 57
DDP 50
sodium 42
arginine 39
SCC 38
calcium 38
aldehyde 37
His 31
iron 31
selenium 31
acetaldehyde 30
tyrosine 28
lysine 27
bromide 24
nitrogen 24
Paclitaxel 24
phosphate 23
BLM 23
TNF 23
retinol 23
hydrogen 22
galactose 21
serine 21
nitrate 20
creatinine 19
retinoic acid 19
acetate 19
ATP 19
GSH 18
CO2 18
MEK 18
glutamine 18
copper 18
GSH 18
alcohol dehydrogenase 18
Optimal 17
Docetaxel 16
MMC 15
PDT 15
methionine 15
ASA 15
pyrene 14
FAP 14
FAP 14
sulfate 13
A 71 12
cysteine 11
N-acetylcysteine 11
alanine 11
salt 11
Phe 11
Vimentin 11
fluorine 11
aluminum 11
nitric oxide 11
vitamin D 11
threonine 10
aldehyde 10
Ile 10
valine 10
molybdenum 10
DEN 10
silver 9
urea 9
nickel 9
formaldehyde 9
MDA 8
proline 8
Methotrexate 8
MTS 8
NH2 8
Cardiol 7
leucine 7
INT 7
DFS 7
glutamate 7
MTX 7
TOF 7
Ascorbic acid 7
CBDCA 7
cobalt 7
DMSO 7
Photofrin II 7
TPA 7
Oridonin 7
CBDCA 7
TPA 7
manganese 7
Insulin 7
Adriamycin 7
VP-16 6
Photodyn 6
COX 6
DMN 6
Photodyn 6
Photodyn 6
Photodyn 6
Photodyn 6
Photodyn 6
Photodyn 6
FB2 6
dUTP 6
methanol 6
NADP 6
ADR 6
silicon 6
Vitamin D 6
Photodyn 6
Photodyn 6
Hoechst 33342 6
Photodyn 6
cAMP 6
ACS 6
Metformin 6
ACS 6
Photodyn 6
CPT-11 6
Photodyn 6
Hypaque 6
Metformin 6
TEM 6
Parenteral 5
PAH 5
isoleucine 5
Nitrate 5
isoleucine 5
Asp 5
phenol 5
acetic acid 5
anthracene 5
cadmium 5
NAD 5
Panam 5
8-OHdG 5
NDMA 5
A 3 5
ADP-ribose 5
NAD 5
folinic acid 4
Thyroid 4
phosphorus 4
pyrimidine 4
A 1 4
AMP 4
tryptophan 4
Gly 4
hydroxide 4
more...