Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0546837 (
esophageal cancer
)
8,907
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Previous studies showed an association between the
ZNF208
gene and gastric cancer. In this study, we investigated the association between single nucleotide polymorphisms (SNPs) in
ZNF208
and the risk of
esophageal cancer
in a Chinese Han population. We conducted a case-control study that included 386 cases and 495 controls. Five SNPs were selected from previous genome-wide association studies and genotyped using the Sequenom MassARRAY platform. Unconditional logistic regression was used to calculate odds ratios and 95% confidence intervals after adjustment for age and gender. Logistic regressionl analysis showed that two SNPs (rs8103163 and rs7248488) were associated with an increased risk of
esophageal cancer
under different inheritance models after Bonferroni correction. Haplotype analysis suggested that the four variants comprised one block, and that the Grs2188972Crs2188971Crs8103163Crs7248488 haplotype was significantly correlated with an increased risk of
esophageal cancer
. Our data indicate that variants in
ZNF208
are contribute to the susceptibility to
esophageal cancer
in a Chinese Han population.
...
PMID:Genetic variants in the ZNF208 gene are associated with esophageal cancer in a Chinese Han population. 2790 11
