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Query: UMLS:C0546837 (esophageal cancer)
 8,907 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Between 1975 and 1986, in Linxian county (LX), a prospective study of esophageal cytological hyperplasia and atypia was conducted on 3 groups of subjects: 294 with marked atypia, 328 with mild hyperplasia and 336 normal controls; all were diagnosed by cytology. Results showed that no significant difference in incidence of esophageal cancer (EC) appeared between subjects with mild hyperplasia and controls, while the incidence of EC in subjects with marked atypia was 1,178.92/100,000 which was 2.39 (after age-adjustment 2.90) times higher than that found in the control group and was of statistical significance (chi 2 = 8.92, p less than 0.01). In all groups, the relatively high risk of contracting EC was closely associated with drinking ground water, smoking and a low standard of living. These results suggest that early treatment should be given to subjects with marked atypia, accompanied by preventive measures against carcinoma of the esophagus, such as hygienic drinking water, abstention from smoking and better living conditions.
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PMID:A prospective study of esophageal cytological atypia in Linxian county. 337 57

The effects of 12-O-tetradecanoylphorbol-13-acetate (TPA), a tumor-promoting phorbol diester, were determined with regard to the induction of esophageal cancer in Wistar rats following a low-dose initial administration of the esophageal carcinogen N-amyl-N-methylnitrosamine [(AMN) CAS: 13256-07-0]. The induction of esophageal cancer was enhanced by TPA given in drinking water after AMN administration; i.e., the incidence of developing esophageal cancers and the multiplicity (number of esophageal cancers per rat) were significantly higher in groups given TPA solution orally after an oral administration of AMN than in those given the AMN solution alone. The enhancement of carcinogenesis with TPA was not affected by the interval between the administration of AMN and the administration of TPA. However, pretreatment with TPA before AMN administration did not enhance the induction of esophageal cancer. Neoplasms were not detected in groups given only TPA or tap water. Because this approach is similar to the phenomenon of two-stage carcinogenesis in the skin, it should provide a meaningful experimental model for studying two-stage carcinogenesis in the esophagus.
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PMID:Enhancement of esophageal carcinogenesis induced in rats by N-amyl-N-methylnitrosamine in the presence of 12-O-tetradecanoylphorbol-13-acetate. 347 38

We investigated the usefulness of endoscopic ultrasonography (EUS) of lymph nodes surrounding the upper GI tract and tried the enhanced EUS by the method of the oral administration of '10% oil-in-water-type emulsion.' The results were as follows: The ultrasonographic visualization rate of lymph nodes surrounding the esophagus was 33.7% in total; however, it was 43.4% for those greater than 5 mm and 58.7% for those greater than 10 mm. The frequency of lymph node metastasis of esophageal cancer was 48.1% for those larger than 10mm with a round shape and 14.3% for the same size with an ellipsoid shape; for those less than 10mm, it was also low. Lymph nodes surrounding the esophagus and the stomach were enhanced by administration of 10% oil-in-water-type emulsion. The visualization rate of lymph nodes can be increased by using this new method. Endoscopic ultrasonography is very useful for the detection of swelling lymph nodes surrounding the upper GI tract before the operation.
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PMID:Endoscopic ultrasonography of lymph nodes surrounding the upper GI tract. 353 34

Catechol (CAS: 120-80-9), given in drinking water to rats, was the most effective of 5 phenols in enhancing [3H]thymidine incorporation [( 3H]dThd-l) into esophageal DNA. To test for esophageal cocarcinogenesis, groups of 30 male MRC-Wistar rats received 3 weekly ip injections of 25 mg methyl-n-amylnitrosamine [(MNAN) CAS: 13256-07-0]/kg. From the time of the first MNAN injection, each group also received catechol, tannic acid (CAS: 1401-55-4), dried leaves of Bidens pilosa L., or croton oil (CAS: 8001-28-3) (respectively, 2, 10, 50, and 2 g/kg semipurified diet), or were given 20 ip injections of 6 mg phorbol (CAS: 17673-25-5)/rat. The rats were killed after 20-45, 46-52, or 53-72 weeks (subgroups A, B, and C). In the group given MNAN alone, most esophageal papillomas developed during the first 45 weeks. Both catechol and B. pilosa significantly increased the esophageal papilloma multiplicity (No. of papillomas/rat) induced by MNAN, with a maximum tumor yield of 2.2 times that in the corresponding subgroup treated with MNAN alone. Papilloma multiplicity increased from subgroup A to subgroup C in the MNAN plus B. pilosa group but not in the MNAN plus catechol group. No tumors were induced by the test cocarcinogens given without MNAN. We concluded that a) an increased esophageal [3H]dThd-I indicates potential cocarcinogenicity and b) catechol and B. pilosa were weak esophageal cocarcinogens. These results support the view that catechol in cigarette smoke and B. pilosa as eaten in South Africa contribute to the etiology of human esophageal cancer.
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PMID:Test of catechol, tannic acid, Bidens pilosa, croton oil, and phorbol for cocarcinogenesis of esophageal tumors induced in rats by methyl-n-amylnitrosamine. 385 97

Pre- and postoperative extravascular lung water (EVLW) changes in a series of twenty patients with esophageal cancer were studied using thermal-dye double-indicator dilution method. Preoperative EVLW was 8.2 +/- 2.3 ml/kg (M +/- SD), being greater as compared to the normal range of EVLW. The pattern of postoperative EVLW changes varied between patients and changes could not be predicted by the conventional examinations including chest X-ray, determination of pulmonary hemodynamics and blood gas analysis. Analysing the relationship between the changes in COP-PWP gradient and EVLW, COP-PWP gradient decreased on the first postoperative day regardless of the EVLW changes. With regard to the changes for the 2nd to the 3rd day or for the 3rd to the 4th day, however, the patients with elevating EVLW showed falling COP-PWP gradient, whereas the patients having decreasing EVLW had an increase in COP-PWP gradient. Especially, the patients in which EVLW had increased during the 3rd to the 4th day showed a remarkable rise of PWP possibly due to depressed left ventricular function. It is considered that the EVLW increase on the first postoperative day is attributable to an alteration of the permeability characteristics of alveolar capillary but that the increase in the 3rd to 4th day is simply due to an elevated hydrostatic pressure. This suggests that there are two different kinds of mechanism involving in the production of wet lung following esophageal cancer surgery.
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PMID:[Studies on pre- and postoperative extravascular lung water changes in patients with esophageal cancer]. 637 85

In order to investigate the relationship between postoperative pulmonary complications after surgery for esophageal cancer and surgical injury to the thoracic vagus nerves, changes of the extravascular lung water volume (EVLW) were studied in 26 mongrel dogs. Two protocols of experiment were designed as follows. In Experiment I (18 dogs), EVLW was measured before and on successive three days after thoracic vagotomy or sham operation. In Experiment II (8 dogs), responses of EVLW to the volume load of saline were studied in previously vagotomized or sham-operated dogs. The measurement of EVLW was performed by thermal-green dye double indicator dilution method. The results obtained were as follows. Values of EVLW as measured by thermal-green dye double indicator dilution method were extremely well correlated with those determined by gravimetric method. After vagotomy, EVLW increased successively. Rate of the increase was greater in dogs with bilateral vagotomy than in those with unilateral vagotomy on the right side. Measurement of various hemodynamics and oncotic pressure revealed no differences between vagotomized and sham-operated dogs. These observations suggested that the increase of EVLW was due to enhanced permeability of the pulmonary capillary wall. The volume load of saline resulted in increase of EVLW in vagotomized dogs, while no changes were observed in sham-operated dogs. The results of the current investigations indicate that the injury to the vagus nerves during surgery for esophageal cancer may induce water retention in the lung, which may be one of the underlying mechanisms of postoperative pulmonary complications.
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PMID:[Extravascular lung water content following thoracic vagotomy. Experimental investigations in relation to the cause of pulmonary complications after surgery for esophageal cancer]. 637 10

Nine-week-old zinc-sufficient (100 mg zinc/kg feed) and zinc-deficient (7 mg zinc/kg feed) noninbred male Sprague-Dawley rats were given free access 5 days a week to deionized drinking water containing low (0.05%) or high (0.25%) quantities of benzylmethylamine (BMA) and concurrently 0.5% NaNO2. In contrast to the action of the preformed carcinogen N-nitroso-N-benzylmethylamine, which almost invariably produced esophageal tumors, oral administration of its precursors, BMA and NaNO2, resulted in forestomach tumors as well. In both the high- and low-BMA groups given precursors for 16 weeks, the incidence of papillomas in both the esophagus and forestomach was significantly higher in the zinc-deficient than in the zinc-sufficient rats, but zinc deficiency did not significantly increase the yield of forestomach carcinomas. However, when combined high BMA and NaNO2 administration was prolonged to 37 weeks, the yield of forestomach carcinomas was significantly greater in the zinc-deficient than in the zinc-sufficient animals. Because endogenous synthesis of N-nitrosamines from ingested precursors is an important source of human exposure to these carcinogenic compounds and because dietary zinc deficiency might be operating in some areas with a high incidence of esophageal cancer, our data are of more than routine significance.
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PMID:Zinc deficiency and the development of esophageal and forestomach tumors in Sprague-Dawley rats fed precursors of N-nitroso-N-benzylmethylamine. 658 27

Occupational studies have shown that asbestos is a human carcinogen. Because many inhaled asbestos fibers deposited in the lung are cleared and swallowed, workers are also exposed through ingestion. Of the millions of current and former workers who have been heavily exposed to asbestos, one in ten will die from cancer of the gastrointestinal tract. A number on the order of 1 in 1,000 ingested asbestos fibers penetrate the digestive tract and ingested fibers have been recovered in such tissues as kidney, intestine, liver, and urine. One animal study showed tumor production related to ingestion of asbestos-containing material but, in general, the results of seven animal feeding studies have been inconclusive. A statistically significant relationship between male lung and stomach cancer and female peritoneal, gall bladder, and esophageal cancer and asbestos counts in drinking water was determined in one epidemiology study. Increased rates for male stomach and lung, and female pancreatic cancer related to asbestos in drinking water were reported in another study but possible occupational exposure made it difficult to draw conclusions. Data on excess gastrointestinal cancer among occupational groups has been used to estimate that drinking water containing 300,000 asbestos fibers per liter over a lifetime will result in one additional cancer among 100,000 people.
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PMID:The need to control asbestos fibers in potable water supply systems. 723 79

In order to study the merit or demerit of the dehydration or hydration as the preparation of renographic examination, the following 25 cases--11 cases of uterine cancer, 2 cases of breast cancer, a case of esophageal cancer, pharyngeal cancer, maxillary cancer, salivary gland tumor, leiomyosarcoma of uterus and others are examined by renography using 131I-hippurate. Renogram is performed in case of patient's dehydration and followed in case of patient's hydration with 600 ml of water intake. Renographic findings such as Tmax, T1/2, HB/HA and step-like pattern are studied as a parameter. Following 600 ml water intake, Tmax is significantly shortened and the step-like pattern is disappeared. This study is strongly suggested that patient's hydration is significantly necessary in the performance of renogram as the preparatory procedure.
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PMID:[The comparative study of renogram both in case of dehydration and hydration (author's transl)]. 738 71

A self-expanding silicone-covered tube constructed of Gianturco stents was used for palliative treatment of esophagorespiratory fistula related to esophageal carcinoma in eight patients. All eight were unable to swallow food or water before treatment. The tubes were inserted under fluoroscopic guidance, without technical failure or complication. Clinical improvement was determined by grading food intake capacity on a five-point scale: none, liquid, soft food, most food, or all food. After the procedure, all fistulas were occluded. Four patients could swallow most foods, two could swallow soft food, one could swallow all foods, and one (who died of preexisting pneumonia 10 days after the procedure) could manage only liquids. Three patients were surviving without symptoms of aspiration for 4-24 weeks. Four patients died 6-16 weeks after placement of the stent tubes. Insertion of a silicone-covered stent tube was an effective palliative treatment for esophagorespiratory fistulas caused by esophageal cancer.
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PMID:Esophagorespiratory fistula associated with esophageal cancer: treatment with a Gianturco stent tube. 768 29


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