Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0546837 (
esophageal cancer
)
8,907
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
IL-11
exerts important functions involved in tumorigenesis and cancer progression. However, the underlying functional role of
IL-11
in esophageal squamous cell cancer (ESCC) is not well known. In this paper, we demonstrated that
IL-11
expression was increased in
esophageal cancer
compared with normal tissues, whereas knockdown of
IL-11
could inhibit the proliferation and invasion of Eca109 and KYSE410 ESCC cells. Besides, we found that the stability and expression of
IL-11
was regulated by lnc-ATB in Eca109 and KYSE410 ESCC cells. More importantly, we found that knockdown of
IL-11
partly abolished lnc-ATB-mediated the proliferation and invasion of Eca109 and KYSE410 ESCC cells. Collectively, these results indicated that
IL-11
mediated by lnc-ATB increased the proliferation and invasion of ESCC cells, which may provide a promising therapeutic option for suppressing ESCC progression.
...
PMID:IL-11 activated by lnc-ATB promotes cell proliferation and invasion in esophageal squamous cell cancer. 3095 89
