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Query: UMLS:C0546837 (esophageal cancer)
 8,907 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The author reports the data characterizing the incidence of cancer, as a whole, and its main localizations in the Republics of Central Asia. According to these findings the cancer incidence indices the Central Asia are more low, as compared with the All-Union data and the data from other Socialist Republics. The main localizations of cancer, except esophageal cancer, are recorded more seldom than in other Republics. Especially low indices of the morbidity were noted in relation to cancer of the skin, lower lip, mammary gland, uterine cervix. In some Republics of Central Asia (Uzbek SSR, Turkmen SSR) the incidence of esophageal cancer was found to be high, exceeding several times the corresponding indices in the USSR and other Socialist Republics.
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PMID:[The epidemiology of cancer in Central Asia]. 12 95

A two-step prophylactic examination was employed in 5921 healthy persons living in rural areas of the Kara-Kalpak ASSR, different malignant tumors being revealed in 47 persons (i. e. in 0.79 per cent of the individuals under examination). It is worth noting that the high rate of recognition of oncological patients in mass prophylactic examinations is mainly due to the use of a fibergastroscope made in Japan. Among the cases with revealed malignancies esophageal cancer takes the first place (in 26 persons), making 55.3%. Large-frame esophagofluorography in 21 patients allowed the detection of the esophageal and cardiac involvement, thus encouraging to raise a question of the organization of large-frame fluorography of the esophagus in persons, aged over 40, in the areas and republics where esophageal cancer is a commonly observed pathology.
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PMID:[Detectability of oncological patients in the Kar-kalpak ASSR based on expedition data]. 14 89

Geographical variations in the incidence of oral cavity, pharyngeal, and esophageal cancer were studied, with special reference to rates in countries outside of the United States and Western Europe. Although reporting techniques differ greatly and comparisons must be made with caution, significant variations are evident. Tracing such differences often reveals possible etiologic factor for these forms of cancer. The roles are discussed of known environmental carcinogens, such as N-nitroso compounds, polycyclic aromatic hydrocarbons, and such cultural habits as smoking or chewing tobacco, excessive consumption of alcoholic beverages, as well as other possible factors in the etiology of these cancer types.
Cancer 1977 Oct
PMID:The epidemiology of oral cavity, pharyngeal and esophageal cancer outside of North America and Western Europe. 19 9

This article, based on the author's visit to China in 1978 as part of a medical delegation, describes China's impressive health care system. The article focuses on 3 specific health care issues: cancer, epidemiology, and family planning. Mass screening, involving exfoliative cytology, for esophageal cancer was carried out in 1971-76 among 40,000 residents over 30 years of age. Cancer mortality is calculated by means of retrospective studies of death certificates. All methods of contraception are used in China; however, abstinence for those under 25 years of age and IUD use are favored. Gossypol has been tested on thousands of male volunteers and has been found to reduce the sperm count by 99%. On the other hand, there is concern that gossypol is a potent mutagen and studies on the incidence of cancer in gossypol acceptors are being conducted.
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PMID:Medicine in China. 26 28

Brief reviews are presented on the occurrence of N-nitroso (NNO) compounds, the chemistry and kinetics of NNO compound formation from nitrite and amines or amides, the in vivo formation of these compounds (as detected by tumor induction) on feeding nitrite with amines or amides to rodents, and the carcinogenicity for rats of some new nitrosamides. The possible human hazard caused by exposure to specific readily nitrosated compounds is reviewed. Whether NNO compounds might be causing human cancer of various organs (e.g., pancreatic, nasopharyngeal, and esophageal cancer) is discussed. Some of our results in [3H]thymidine incorporation in the rat esophageal epithelium are presented. Nitrosamines that cause esophageal cancer in rats were found to inhibit [3H]thymidine incorporation, both in vivo and in vitro, when esophagi were incubated with nitrosamines. With reference to the hypothesis that human gastric cancer is caused by nitrosamides (e.g., nitrosoureas), certain correlations were examined between gastric cancer and environmental exposure to nitrate, nitrite, and nitrosatable amides. In studies from our laboratory, dried, salted fish, which was treated with excess nitrite at pH 1 and then "denitrosated" at pH O, yielded 16 mg methylurae/kh fish, possibly derived from methylguanidine.
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PMID:N-nitroso compounds: their chemical and in vivo formation and possible importance as environmental carcinogens. 32 17

It is suggested to use the medico-mathematical "decisive rules" for the differential diagnosis of esophageal cancer in non-specialized medical institutions. As the first step the examination cards were written, based on the data of 1195 patients with verified diagnosis. The "decisive rules" were worked out basing on the examination cards of 597 patients (in 267--esophageal cancer and in 330--benign lesions: cardiospasm, benign tumors, cysts, burn and scarring strictures, esophagitis, diverticulum). The suggested "decisive rules" using 63 and 87 clinical signs were tested elsewhere for a retrospective diagnosis in 167 patients. Using the "decisive rules" with 63 clinical signs esophageal cancer was recognized in 96% of cases, non-cancer--in 92%, while using 87 signs--in 92 and 94% accordingly. The rule comprising 63 signs-questions is recommended for practical purposes.
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PMID:[Differential diagnosis of esophageal cancer by using mathematical decision rules]. 38 64

The management of 2032 patients with squamous esophageal cancer seen in Edinburgh from 1931 to 1969 was studied. Since 1949 more radical surgical treatment has been offered and since 1956 more radical radiotherapy. From 1949 to 1969 there has been a swing over from mainly surgical to mainly radiation treatment associated with a rise in the overall one and five-year survival rates to 32% and 9% respectively. The main reason for failure is the prevalence of disseminated disease. The significant mortality of surgical treatment limits its usefulness. Too often, radiotherapy fails because of recurrence of tumor within the irradiated volume. In the upper 2/3 of the esophagus irradiation is preferable to surgery because of better sirvoval. In the lower 1/3 the two methods achieve similar long term survival but following irradiation the short term survival is better and the patient retains a normal stomach. Improvement could be achieved by prevention, earlier diagnosis, improved tumor delineation and a wide range of measures to improve the local effectiveness of irradiation.
Cancer 1977 Feb
PMID:The present status and future potential of radiotherapy in the management of esophageal cancer. 40 1

Previous reports on radiation myelopathy of the thoracic spinal cord have attempted to predict tolerance doses as a function of overall treatment time and number of fractions by extrapolation of data from collected myelopathy cases having markedly heterogeneous treatment parameters. A review of long term survivors receiving radical radiotherapy with conventional fractionation for lung and esophageal cancer was undertaken to determine if the proposed tolerance levels were consistent with clinical results in a series of patients constituting the group at risk for developing myelopathy. Spinal cord doses were determined in 58 patients who survived greater than or equal to 18 months following radiotherapy. All patients were treated with megavoltage equipment at dose rates of 200 rads/day continuously (53 patients) or 250 rads/day using split course (5 patients). Tumor doses ranged from 4500 rads to 7000 rads. Seventeen patients (29%) received less than 5000 rads to the thoracic cord, 6 patients (10%) received 5000 rads, and 35 patients (61%) received greater than 5000 rads. There were two patients who developed myelopathy. Review of our data, the clinical data of others and recent experimental results suggest that the slope of tolerance curves for thoracic spinal cord commonly utilized to express time-dose-fractionation relationships may be inappropriate. It is suggested that cord tolerance to well fractionated radiation has been previously underestimated.
Cancer 1978 May
PMID:Radiation myelopathy of the thoracic spinal cord in long term survivors treated with radical radiotherapy using conventional fractionation. 41 97

Lipotropin (LPH) has been evaluated as a potential tumor marker using a sensitive beta melanocyte-stimulating hormone (beta MSH) radioimmunoassay. All 79 acetic acid extracts of carcinomas of lung, colon, stomach, esophagus and breast contained LPH in concentrations greater than blood; 61 of 79 extracts contained LPH in larger amounts than control tissues from patients without cancer. In a blind prospective study, plasma LPH was quantified in 107 patients admitted for work-up because of an abnormality on a chest roentgenogram. Thirty-one of 33 patients subsequently diagnosed as having benign lesions had plasma LPH within the 95 per cent confidence limits of normal subjects whereas 28 (36 per cent) of the 74 patients subsequently diagnosed histologically as having primary lung carcinoma had elevated levels. In control studies, 13 of 100 patients with chronic obstructive pulmonary disease had elevated plasma LPH levels; three of the 13 with elevated levels and four with normal levels have been diagnosed, during the two years of follow-up, as having lung carcinoma. In control studies of 23 patients with granulomatous lung disease, 22 had normal levels of LPH. In those with carcinoma of the colon elevated plasma LPH levels were observed in two of 21 untreated patients and in 11 of 61 patients receiving noncurative chemotherapy. Elevated plasma LPH levels were also observed in 10 of 59 patients with breast cancer, eight of 28 with pancreatic cancer, eight of 22 with gastric or esophageal cancer, six of 16 with renal cancer, four of eight with prostatic cancer, one of seven with cervical cancer and one of six with ovarian cancer. We conclude, an elevated LPH level is frequently observed in blood and tumor tissue from patients with various types of carcinoma.
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PMID:Ectopic production of lipotropin by cancer. 43 67

We developed a new method to determine the depth of esophageal cancer invasion prior to surgery. According to this method, a fiberoptic esophagoscope is used to insert a double cannula into the biopsy canal and the submucosal layer is punctured and fixed by the needle at the tip of the inner cannula through which iodized oil fluid is injected into the submucosal layer. After this procedure, plain films of the posterior mediastinum and an esophagogram are taken in at least four different directions at 24 hour, three and seven day intervals. Seventy one esophageal cancer patients were examined with this method in order to determine the depth of invasion, and whether the adventitia was involved. In three cases the method failed due to technical difficulties and in 14 surgical treatment was not indicated. In 50 of the 54 remaining patients who underwent surgery, preoperative results obtained by using this method coincided well with operative findings. Our findings strongly indicate that this method is diagnostically highly accurate in determining the surgical procedure to be used. Furthermore, this method was proven very useful in obtaining a differential diagnosis of the malignancy of submucosal esophageal tumors,
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PMID:Submucosal esophagography: a new method for demonstrating the depth of invasion of esophageal cancer. 43


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