Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0519030 (Klebsiella)
 21,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Inhibitory activity of cephalexin, cephradine, and cefaclor was compared by the WHO-ICS agar dilution technique. Cefaclor was substantially more active against staphylococci, streptococci, gonococci, meningococci, Haemophilus, Escherichia coli, Klebsiella pneumoniae, Citrobacter diversus, Proteus mirabilis, salmonellae, and shigellae than was cephalexin, which in turn was more active than cephradine. Cefaclor appeared to be less resistant to staphylococcal penicillinase than did the other two agents. None of these cephalosporins was active against Enterobacter, Serratia, indole-positive Proteeae, Pseudomonas, or Bacteroides fragilis.
 ...
PMID:Comparison of in vitro activity of cephalexin, cephradine, and cefaclor. 30 Oct 5

Sisomicin and gentamicin were tested in vitro against 222 clinical isolates of pathogenic bacteria using the ICS agar dilution procedure. The two drugs were comparable in terms of overall activity although statistical analyses of the data revealed significant differences in their activity against several genera. Sisomicin was significantly more active against Pseudomonas aeruginosa (p less than 0.001), Proteus mirabilis (p less than 0.005), and Escherichia coli (p less than 0.01); gentamicin was significantly more active against Klebsiella (p less than 0.001). In most instances, 4.0 mug/ml of either drug was inhibitory for 90% or more of the isolates of each genus tested.
 ...
PMID:In vitro studies with sisomicin and gentamicin. 82 25