Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0519030 (
Klebsiella
)
21,988
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
1-Deoxynojirimycin (DNJ) exerts hypoglycemic effects. However, the traditional method for DNJ extraction is inefficient, and the hypoglycemic mechanism of DNJ remains unclear. In this study, the mixed fermentation by
Lactobacillus fermentum
and
Saccharomyces cerevisiae
was used to enhance DNJ extraction efficiency. It was found that this strategy was more efficient than the traditional method as the yield improved from the original 3.24 mg/g to 5.97 mg/g. The purified DNJ significantly decreased serum glucose (
P
< 0.01) and insulin levels (
P
< 0.05), improved serum lipid levels (
P
< 0.05), and reversed insulin resistance (
P
< 0.05) in diabetic mice. These changes were caused by up-regulating the protein expression of insulin receptor and glycolysis enzymes (GK, PK, and PFK) (
P
< 0.05) and down-regulating the protein expression of insulin receptor substrate-1 and gluconeogenesis enzymes (PCB, PEPCK,
FBPase
, and G-6-Pase) (
P
< 0.05), thus alleviating glucose tolerance. Additionally, DNJ treatment relieved gut dysbiosis in diabetic mice by promoting the growth of
Lactobacillus
,
Lachnospiraceae NK4A136 group
,
Oscillibacter
,
norank Lachnospiraceae
,
Alistipes
, and
Bifidobacterium
(
P
< 0.05) and suppressing the growth of
Ruminococcaceae UCG-014
,
Weissella
,
Ruminococcus
,
Prevotellaceae Ga6A1 group
,
Anaerostipes
,
Klebsiella
,
Prevotellaceae UCG-001
, and
Bacteroidales S24-7 group
(
P
< 0.05).
...
PMID:Effect of 1-Deoxynojirimycin Isolated from Mulberry Leaves on Glucose Metabolism and Gut Microbiota in a Streptozotocin-Induced Diabetic Mouse Model. 3139 24
