Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0519030 (
Klebsiella
)
21,988
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The aim of the study was to investigate the leukocyte- and platelet-rich plasma (L-PRP) antimicrobial activity. The studied sample comprised 20 healthy males. The L-
PRP
gel, liquid L-
PRP
, and thrombin samples were tested
in vitro
for their antibacterial properties against selected bacterial strains using the Kirby-Bauer disc diffusion method. Two types of thrombin were used (autologous and bovine). Zones of inhibition produced by L-
PRP
ranged between 6 and 18 mm in diameter. L-
PRP
inhibited the growth of
Staphylococcus aureus
(MRSA and MSSA strains) and was also active against
Enterococcus faecalis
and
Pseudomonas aeruginosa
. There was no activity against
Escherichia coli
and
Klebsiella
pneumoniae
. The statistically significant increase of L-
PRP
antimicrobial effect was noted with the use of major volume of thrombin as an activator. Additionally, in groups where a bovine thrombin mixture was added to L-
PRP
the zones of inhibition concerning MRSA,
Enterococcus faecalis
, and
Pseudomonas aeruginosa
were larger than in the groups with autologous thrombin. Based on the conducted studies, it can be determined that L-
PRP
can evoke
in vitro
antimicrobial effects and might be used to treat selected infections in the clinical field. The major volume of thrombin as an activator increases the strength of the L-
PRP
antimicrobial effect.
...
PMID:Antibacterial Activity of Leukocyte- and Platelet-Rich Plasma: An
In Vitro
Study. 3005 Sep 49
